DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kmr and Gab1

DIOPT Version :9

Sequence 1:	NP_001097775.2	Gene:	kmr / 5740131	FlyBaseID:	FBgn0085412	Length:	3090	Species:	Drosophila melanogaster
Sequence 2:	XP_038953748.1	Gene:	Gab1 / 361388	RGDID:	1311085	Length:	729	Species:	Rattus norvegicus

Alignment Length:	584	Identity:	124/584 - (21%)
Similarity:	192/584 - (32%)	Gaps:	191/584 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1091 PPSASGIQRSRSESQANVGPGGVVYN---NYSSD-----DEAGTVDDDNLY--SATAGRSSSSKT 1145
            ||..:.:.          |..| :||   :||.|     ..:.|..|..||  :..:|.||....
  Rat   251 PPRVTSVS----------GESG-LYNLPRSYSHDVLPKESPSSTEADGELYVFNTPSGTSSVEAQ 304

  Fly  1146 TTKATTSQAIVATTTAALAIT------NLGSSKNLET-----------PNQT------ETEATPS 1187
            ....:.|..|..|......:.      .||.|..|:|           |:.|      ||...|
  Rat   305 MRHVSISYDIPPTPGNTYQVPRTFPEGTLGQSSKLDTIPDVPPPRPPKPHSTHDRSPVETCGVP- 368

  Fly  1188 SSSTASSTKAKFQLKPILKVHEASKTRIIQVQPKHLEERPKLR--------LQLPKAMGNEEEQK 1244
              .|||.|.:.:.:.|.......|.| |..|      :..|||        ..:|:...::....
  Rat   369 --RTASDTDSSYCIPPAGMPPSRSNT-ISTV------DLNKLRKDAGSQDCYDIPRTFPSDRSSS 424

  Fly  1245 QEDEEQE----------NVEAEP-----VPILPKKTAPKSP-------QNANYVPVYNNKLVSNY 1287
            .|....:          ||..|.     ||:.|.......|       |..||||:    ....:
  Rat   425 LEGFHNQLKIKNVLAAGNVSGEELDENYVPMNPNSPPRHHPSSFAEPIQEPNYVPM----TPGTF 485

  Fly  1288 ENMEFGKPIPESKIPHSNAAITDPEETPMLMQLKLFKEQQDQQKQQQENEEEDLTPTAESKPIPG 1352
            :...||..:|    |.::.......:||....:                      |.|:.:|.|.
  Rat   486 DFSAFGMQVP----PPAHLGFRSSPKTPPRRPV----------------------PVADCEPPPV 524

  Fly  1353 EEDM------GAPKVIKDQKLESNEEEQELEDEDDSTACEEYTDDDIDEALAQDDEDEAVVEAVE 1411
            :.::      .:||:::       .:...||..|..|.....|...:..|            .:|
  Rat   525 DRNLKPDRKGQSPKILR-------PKPHGLERTDSQTVGGFATRRKVKPA------------PLE 570

  Fly  1412 SQELAEERELQQIYVNEPITPTDQQFDESHYLPMTPKKVELGQPGVLTLVSATYAEEEEENHYVE 1476
            .:.|:|..|| |..|..|||.:..: |.|.: ||:|:     ...|.:..|::.:.:.||| ||.
  Rat   571 IKPLSEWEEL-QAPVRSPITRSFAR-DSSRF-PMSPR-----PDSVHSTTSSSDSHDSEEN-YVP 626

  Fly  1477 MTKGIQDED----CRSNYEIMCLASTSSSAFKVTTKTEPVYMELAGVKASSAVPATEEAHCSSGR 1537
            |...:.:||    |.::.|     ..||...|.....:..|::|               ...||:
  Rat   627 MNPNLSNEDQNLFCNNSLE-----GASSPMTKPKGDKQVEYLDL---------------DLESGK 671

  Fly  1538 ST-LKKCKKSGTETLKKKTKKRQGKDMPD-----ILKPAKSALALASDSSDADDESSRQQLEAK 1595
            || .:|.|.||:           |..|.|     ::...:..|||.|......|  .||..|::
  Rat   672 STPPRKQKNSGS-----------GSSMSDERVDYVVVDQQKTLALKSTREAWTD--GRQSTESE 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
kmr	NP_001097775.2	PH_PEPP1_2_3	366..469	CDD:270068
kmr	NP_001097775.2	PH	372..469	CDD:278594
Gab1	XP_038953748.1	PH-like	30..130	CDD:418428
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910