DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kmr and AgaP_AGAP000124

DIOPT Version :9

Sequence 1:	NP_001097775.2	Gene:	kmr / 5740131	FlyBaseID:	FBgn0085412	Length:	3090	Species:	Drosophila melanogaster
Sequence 2:	XP_566290.4	Gene:	AgaP_AGAP000124 / 3289620	VectorBaseID:	AGAP000124	Length:	1416	Species:	Anopheles gambiae

Alignment Length:	1127	Identity:	206/1127 - (18%)
Similarity:	355/1127 - (31%)	Gaps:	356/1127 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 QQQQQQQQQQQQQQQQQRA------------------PPSSLNLQ------NQYQPAQG------ 229
            ||||.|.|.:|.|||||..                  |||.:.|.      :.|:...|
Mosquito   327 QQQQYQLQHEQYQQQQQLGHRRSQSLPPKLGIKLFIPPPSKIGLVFTNPSIHTYRLHSGLGGDIS 391

  Fly   230 --------------PLKL------QQQQQQQQ-----------QQSQQPAMPKHYQEQLYAQQQQ 263
                          |.:|      ::::..|:           :|.|...:.||.  :|.....|
Mosquito   392 VLEVMLESYLCYIIPQQLLSVWIAREKELLQEISGMGELGGEWRQRQMELLDKHL--KLLKDYSQ 454

  Fly   264 LQQQLHQQQQQQQQLQQQ-----------------QQQHRHKNDLQTPG-SEHGTVYIQQNHPNH 310
            .:|.||||||:.:..:..                 |:...|.:.|:..| .:..||.....|...
Mosquito   455 AKQHLHQQQQRGRSFKPSCRKGDETLEFAPVNLHLQRMWAHNDTLKRAGILDVVTVGAFTRHSGK 519

  Fly   311 VVNQACQTQISAVKPKATPSSEESSSNSTKSPSHAPLDRKKSAGSIQALKSPITK---------- 365
            .........:..:|.  :||..|.        .|.......:..:|:.|:..|.:
Mosquito   520 TKTGGLIKLLHQIKD--SPSKSEG--------QHKVAAANDAVQAIKQLRKEIVEIMSQLLYLAK 574

  Fly   366 -RPPSTPVTLSGWLHKQGSDGLKVWRKRWFVLAEYCLYYYKGPEEEKLL---------------- 413
             :.|...:.|...:..:....|.:|...   |.|....:.   |..:::
Mosquito   575 SKNPKGMLPLCNEMMTKTRALLNIWEPS---LVEEAFAFI---ERHRIIDDATAGGGAEPGDTGG 633

  Fly   414 -------GSVLLPSYRVSACLPEDKIYRKF-AFKCEHQNMRTYWLAADNSEAMMQWVRALAAASL 470
                   ||:...|..|:|..|..||.::. |...:...:..:......:..:...||...:.:|
Mosquito   634 RDGGGGGGSLTTNSLTVTAMSPFKKITQQLGALDLKSPELEDFSTPMGPAPDLWPQVRTSKSGTL 698

  Fly   471 ---------MQAPSS---GESEPSVNSSLNH------SGENSDSGI-----HTLQS--HPGKGQP 510
                     :.:|.|   .::..::.||.:.      .||.|..|.     :||.|  :....||
Mosquito   699 AVPRAKPPVVPSPPSLDLSDTIATIQSSFSQLQQDGAEGEQSGHGSQAAAPYTLPSPCYLPTEQP 763

  Fly   511 TPSSENTGSSGGGSG----------SGQPLYANAPPKPRRINDGGYSSPSPEHNEQQQQHPSRRL 565
            :.|..|..|:|||..          :|:...::.||....:.....|.|.|       |..|...
Mosquito   764 STSKANKLSTGGGGAVTFSETHFDINGEVTLSHVPPTVPAMKPAAGSEPPP-------QLASLPN 821

  Fly   566 MSPTQQLYQQQQHQRSQQQQQQQPQQHHAIYDTR--TGHVSTALQLQQAQQQYSLDHLEAQFQQQ 628
            |..:.....|....:::.......:|.:.|.:|.  .||....|..:......|.::.....:.:
Mosquito   822 MGSSTLTANQLLENKNELLSNVYDEQGYLIENTAIVLGHNGAFLDTKVMSSSPSANYYRPTEEPE 886

  Fly   629 -----QLDMEEQIARLQQQRAAEEIYGEREMYMAKLMQQRQGPNGTY--PTQQQLLQAERRTPDA 686
                 ||::|..:..|..:  .:.:.|.......:|...:....||.  ||..:.||       .
Mosquito   887 PLDLTQLNIEASVMCLVSK--VKFLCGRCGSPAVRLRAPKGSTLGTLQRPTSIETLQ-------T 942

  Fly   687 YGRSKQQRLFAAAAAAADYEDIYNMSQLAGGGGVPMSAQE------ALLQEAA---SYRRPLSPP 742
            |..:.|......||.||:     ::|:.|.|.....:.:|      |.:.:.|   ...:..:||
Mosquito   943 YVVTSQPLSLPQAAGAAE-----SVSKPAAGREADPAQEEQTPPTPATISDVALCGIEMKATAPP 1002

  Fly   743 SYDGSKHVP-AMPQRYTPNHLEASAADQLINTMDLRARTAAAI-VRP------------------ 787
            |...||.:. |:.|.......:....::..:.:||.|.|..|: :||
Mosquito  1003 SLSTSKELNLALTQAVGEVARKVKKGNKFTDGLDLSATTDWALELRPSMKKLRQAMDGLLKTARL 1067

  Fly   788 -HSADFLEYEARAEAAAAAA--AAAVAQSQQESGRAPRPKSSLDINRTPDSF------------- 836
             ||...|:.:.|..:|..|.  ...|..||..:.......:.|......::|
Mosquito  1068 MHSVQRLQQDMRKTSATLAIMYRRDVCFSQALTSLVAGLMAKLWGQNVTENFISVLVHLGPLAYF 1132

  Fly   837 ------YYSE--------------ASYADKMRKSALYLQSGG-------AGAAQ----------- 863
                  |.:|              |:....:.:|.|:..:.|       ||:.|
Mosquito  1133 EGLLSLYGNETDMWGDMSVAVEDLATVGFTLVRSNLHRDTKGAIPVPRVAGSRQALRVLLPVPES 1197

  Fly   864 ------PQQPGSYRTTGADFNSGVN-------TIGYENPYERAYKRQELLAEAQGGGASSMPRMS 915
                  .::..|:|.|...||.|:|       |:|:.....|:             ...:..|:.
Mosquito  1198 VFCHLPTKEAVSFRVTPVFFNIGINEKATVAETLGFTREQHRS-------------NWDNYDRLK 1249

  Fly   916 RSASQGRSV----------ASQ--------LQSPQQEDLPP--------------LNVHPGSIFP 948
            :..|:.|.|          |||        ..:||:|.|.|              |..: ||...
Mosquito  1250 QYHSRYRKVPFNFVNPHCSASQDTPTKVGAYTTPQKELLVPEHTVVKFLADLEGELRAN-GSKNY 1313

  Fly   949 PSMSTQEIISKNEQFLRSASARLPKRSGGM------------DDDYSAGNS---TTTSPTGGAGA 998
            ..:...|.:::..|.||..|.:..|....|            :...||||:   ..|..:.|..:
Mosquito  1314 AILQLAEEVTRAVQGLRFTSCKSAKDRTSMAVTLEQCRVLQQEFHLSAGNAQNVLNTMRSEGTRS 1378

  Fly   999 SNSPQHNLDGERKREESMKRLL 1020
            .|:.::  .|.||...:|.::|
Mosquito  1379 DNTMKN--VGTRKYAFNMPQVL 1398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmr	NP_001097775.2	PH_PEPP1_2_3	366..469	CDD:270068	18/126 (14%)
kmr	NP_001097775.2	PH	372..469	CDD:278594	17/120 (14%)
AgaP_AGAP000124	XP_566290.4	PH_INPP4A_INPP4B	1..146	CDD:270091
		PH	30..119	CDD:278594
		C2	167..277	CDD:301316
		Pollen_allerg_1	989..>1052	CDD:298693	15/62 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910