DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kmr and Plekhh2

DIOPT Version :9

Sequence 1:	NP_001097775.2	Gene:	kmr / 5740131	FlyBaseID:	FBgn0085412	Length:	3090	Species:	Drosophila melanogaster
Sequence 2:	NP_001178699.2	Gene:	Plekhh2 / 313866	RGDID:	1304935	Length:	1488	Species:	Rattus norvegicus

Alignment Length:	1487	Identity:	267/1487 - (17%)
Similarity:	462/1487 - (31%)	Gaps:	403/1487 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   892 RAYKRQELLAEAQGGGASSMPRMSRSASQGRSVASQLQSPQQEDLPPLNVHPGS----IFPPSMS 952
            :|.|.:||||:..    ..:.|....|.:....|.|.....:|.|...|:....    ::.....
  Rat    30 QASKIRELLADKM----QQLERQVIDAERQAERAFQEVQVMEEKLKAANIQTSESETRLYKKCQD 90

  Fly   953 TQEIISKNEQFLRSASARLP-------KRSGGMDDDYSAGNSTTTSPTGGAGASNS-----PQHN 1005
            .:.::.:.:..:::.:.||.       |.:..:::..:......|.........|.     .|..
  Rat    91 LESVMQEKDDLIQNLALRLEEQKQVRIKEAKTIEEKAAKIKEWVTVKLNELEVENQNLRFINQTQ 155

  Fly  1006 LDGERKREESMKRLLEWKQRMLQSPLTRKGIQQGGSNMSAMSKLGSNPNILLASTAVASGARYAP 1070
            .:..|..:..::.|.|.|...:.||...:|.:..............:|...:.|...:..|...|
  Rat   156 TEELRAIQSKLQELQEKKVSCVSSPKPSEGQRLSSLTFGCFLSRAKSPPCAVRSEEASKMASSEP 220

  Fly  1071 QAGKTVLVGNGNGTAQGAGNP------------PSASGIQRSRSESQANVGPG------GVVYNN 1117
            :..:...|.......:.|.|.            .::.|.:.:|....:.|..|      |:..::
  Rat   221 EFAEARCVEEMEIAEKPADNQVQENSRSQRKLLETSCGSEHNRKTGASFVADGGTPEHSGLPVSD 285

  Fly  1118 YSSDDEAGTVDDDNLYSATAGRSSSSKTTTKAT------------TSQAIVATTTAALAI----- 1165
            :||||:.|          :.|||.|..|:|.::            .|:|.:..:..:.:|
  Rat   286 WSSDDDDG----------SKGRSKSRCTSTLSSHTSEEGGQCGRPGSEAYLTASDDSSSIFEEET 340

  Fly  1166 --TNLGSSKNLETPNQTETEATPSSSSTASSTKAKFQLKPILKVHEASKTRIIQVQPKHLEERPK 1228
              .|....|.|.:..|......||:.:..||...       :|..::|...:
  Rat   341 FDANRPQHKKLYSWQQKAPWKAPSNLAKGSSQSE-------VKQRDSSSDEL------------- 385

  Fly  1229 LRLQLPKAMGNEEEQKQE-DEEQENVEAE-PVPILPKKTAPKSPQNANYVPVYNNKLVSNYENME 1291
                      |::.|.|. |....:.||. |.|||.....||.|   |.:|.....||.    ..
  Rat   386 ----------NKKFQSQRLDYSSSSSEANTPSPILTPALTPKHP---NSLPGKGTPLVP----PP 433

  Fly  1292 FGKPIPESKIPH---SNAAITDPE-ETPMLMQLKLFKEQQDQQKQQQENEEEDLTPTAESKPIPG 1352
            | .|.|:.:||:   .:.|:|... ..|.|...::|
  Rat   434 F-LPPPKLRIPNVFSISVALTKRHLSQPQLCSDRMF----------------------------- 468

  Fly  1353 EEDMGAPKVIKDQKLESNEEEQELEDEDDSTACEEYTDDDIDEALAQDDEDEAVVEAVESQELAE 1417
              .|....:...:.|...|.:.::.|.|.:.|. :..|....:..:.|.:|....|..|:.|..:
  Rat   469 --GMNRNAISMIRPLRPQETDLDMVDGDRAEAV-DIMDTGCGDLFSYDSQDPPSAEDPENSEATK 530

  Fly  1418 ERELQQIYVNEPITPTDQQFDESHYLPMTPKKVELGQPGVLTLVSATYAEEEEENHYVEMTKGIQ 1482
            :..     .::|.||      ..|..|....::              ||..:..   :.:::...
  Rat   531 KAS-----CSKPPTP------PLHRFPSWESRI--------------YAVAKSG---IRVSEAFN 567

  Fly  1483 DEDCRSNYEIMCLASTSSSAFKVTTK--TEPVYMELAGVKAS--SAVPATEEAHCSSGRSTLKKC 1543
            .|:...|...:...|.:.....:..|  |.|||..|.| ||:  |..|..::   |||.......
  Rat   568 MENANKNAASLLSHSVAGPYMSLIYKNVTTPVYTTLKG-KATQISTSPFLDD---SSGSDEEDGS 628

  Fly  1544 KKSGTETLKKKTKKRQGKDMPDILK-----PAKSALALASDSSDADDESSRQQLEAKKLRSRSRF 1603
            :.|.....:.:|:.|.|.:.|..:|     .::...|:..|:...|.|.|  |.|.|.|::.|..
  Rat   629 RASSRSQSESETRSRSGPNSPRAMKRGVSDSSEGDYAIPPDAYSIDTECS--QPEQKLLKTCSTS 691

  Fly  1604 S---LSDTFRPASYYLGASTPLNNYAES----SDSEIL---PPPPIPASPPPMEELKTEEIFSSE 1658
            |   .|:....:.|.|..|..|..:...    ...|:|   .|..:...|....||...
  Rat   692 SDNGKSELLEKSGYLLKMSGRLKTWRRRWFVLKGGELLYYRSPSDVIRKPQGHIELSAS------ 750

  Fly  1659 HYDTVKRKDSNGKVNLSYEQLPKMHASNTSLNLPKAVPSPTLKSSRLSLPDHFTKVRMTPQRLLV 1723
              .::.|.|:...|.|:.|:    |....:.:      ||.:....:.:..:..:|:......|.
  Rat   751 --CSILRGDNKQTVQLTTEK----HTYYLTAD------SPNILEEWIKVFQNVLRVQAANPLCLQ 803

  Fly  1724 PATPPQQHHARTLSDSNYS----CQLTDTSSRTSSDLDLYRRRGQQQRCTSNNSLPLSS----EN 1780
            |...|......|.....||    |.|....        ||..|.|:.:      .||..    |.
  Rat   804 PEGKPTVKGLLTKVKHGYSKRVWCTLVGKC--------LYYFRSQEDK------FPLGQIKLWEA 854

  Fly  1781 ESVEFRQRSDSELDRQRSRRPLSQESISEIESLSEQFEETL---SSHELDTYLSHLHLSTG---- 1838
            :..|..:..||:.|.:.|.|.|.....:.|....:|....|   |.||.:.:|.||.::.|
  Rat   855 KVEEVDRSCDSDEDYETSGRCLLSTHYTIIVHPKDQGPTYLLIGSKHEKEAWLYHLTVAAGSNNV 919

  Fly  1839 ----------------QATPTSH-------------LLNDANAAAGADILTNLIKPPKT---FRN 1871
                            :..|:|.             :|....:.....:.|..||..||   |.|
  Rat   920 NVGSEFEQLVCKLLNIEGEPSSQIWRHPMLCHSKEGILCPLTSLPSEALQTEAIKLFKTCQLFIN 984

  Fly  1872 AEDEEQHFYGNIHFLSSTDSI-----QQLGEAGATALRIIHSRNNSNISTQSAPYYYSELPAPPP 1931
            |..:......:|....|...:     :...|.....::....|...|   |:.|....:|.|
  Rat   985 AVVDSPAIDYHISLAQSALQVCLTHPELQSEICCQLIKQTRRRQQQN---QAGPLQGWQLLA--- 1043

  Fly  1932 LNNQRDIHAHGLNIAHIHNPIDRHQFNVDALVDKDQAIDSKN------IYCGQKDNNEKLSNKNL 1990
                   ...||.:.|       |.|.....|...::.||:.      ||| |:.....|.|.:.
  Rat  1044 -------LCVGLFLPH-------HPFLWLLQVHLQRSADSRTEFGKYAIYC-QRCVERTLQNGDR 1093

  Fly  1991 KLNKSVDLPAEMEGSGSSGGALNPVVHS---------------------YLTTTKNTNLARKTIG 2034
            :..     |:.||...:.  ..||..||                     ..|..:..|...:..|
  Rat  1094 EAR-----PSRMEILSTL--LRNPYHHSRPFSIPVHFMNGIYQVVGFDASTTVEEFLNTLNQDTG 1151

  Fly  2035 GSNPSDDGNP--NEDGAGENTE-----------------------EAGK---------TPSNNVH 2065
            ...|:..|..  .:|.:|.:.|                       :.||         |..|.::
  Rat  1152 MRKPAQSGFALFTDDPSGRDLEHCLQGNIKICDIISKWEQASKELQPGKCEGSRTVRLTYKNRLY 1216

  Fly  2066 TNLSVLGGELLWEEDALWRESLRRVSQRHAR-----------------------SLDDLDRITAA 2107
            .::...|     |.|   ||.|..:.|.:.:                       .:.|.:|..:.
  Rat  1217 FSMQARG-----ETD---REKLLLLYQTNEQIINGLFPLNKDLALEMAALLAQVDIGDFERPFST 1273

  Fly  2108 PPISSTPKAKLSREVTYVNDSLKPRQHPHITNE---HDVYVQLMDTTSSSHDHDQTD 2161
            |....|.:.|.::.:..|.:...|:::....:|   ..:|.:|.....:...|..||
  Rat  1274 PAGHVTNQCKANQTLKQVVEKFYPKRYREGCSEEQLRQLYQRLSTRWMALRGHSTTD 1330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmr	NP_001097775.2	PH_PEPP1_2_3	366..469	CDD:270068
kmr	NP_001097775.2	PH	372..469	CDD:278594
Plekhh2	NP_001178699.2	SMC_N	<20..>254	CDD:330553	33/227 (15%)
		PH1_PLEKHH1_PLEKHH2	702..797	CDD:241436	19/112 (17%)
		PH-like	800..>869	CDD:327399	18/82 (22%)
		MyTH4	951..1106	CDD:214535	35/180 (19%)
		B41	1119..1350	CDD:214604	32/220 (15%)
		FERM_C-lobe_PLEKHH1_PLEKHH2	1346..1444	CDD:241360
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910