DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kmr and DAPP1

DIOPT Version :9

Sequence 1:	NP_001097775.2	Gene:	kmr / 5740131	FlyBaseID:	FBgn0085412	Length:	3090	Species:	Drosophila melanogaster
Sequence 2:	NP_055210.2	Gene:	DAPP1 / 27071	HGNCID:	16500	Length:	280	Species:	Homo sapiens

Alignment Length:	184	Identity:	43/184 - (23%)
Similarity:	65/184 - (35%)	Gaps:	58/184 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 GSEHGTVYIQQNHPNHVVNQACQTQISAVKPKATPSSEESSSNSTKSPSHAPLDRKKSAGSIQAL 359
            |||.||:.:.: ||                   .|...|..|.......|..:...::...:
Human   116 GSETGTLMVLK-HP-------------------YPRKVEEPSIYESVRVHTAMQTGRTEDDL--- 157

  Fly   360 KSPITKRPPSTPV--TLSGWLHKQGSDGL-KVWRKRWFVLAEYCLYYYK---GPEEEKLLGSVLL 418
                   .|:.|.  |..|:|.|||  || |.|:.|||.|....|.|:|   .||..::|.
Human   158 -------VPTAPSLGTKEGYLTKQG--GLVKTWKTRWFTLHRNELKYFKDQMSPEPIRILD---- 209

  Fly   419 PSYRVSACLPEDKIYRKFAFKCEHQN-------MRTYWLAADNSEAMMQWVRAL 465
                ::.|...     :|.:..|..|       .||::|.|.......:|::.|
Human   210 ----LTECSAV-----QFDYSQERVNCFCLVFPFRTFYLCAKTGVEADEWIKIL 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmr	NP_001097775.2	PH_PEPP1_2_3	366..469	CDD:270068	32/113 (28%)
kmr	NP_001097775.2	PH	372..469	CDD:278594	30/107 (28%)
DAPP1	NP_055210.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		SH2_DAPP1_BAM32_like	28..119	CDD:198218	2/2 (100%)
		PH_DAPP1	163..258	CDD:269977	30/107 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910