DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kmr and IPCEF1

DIOPT Version :9

Sequence 1:	NP_001097775.2	Gene:	kmr / 5740131	FlyBaseID:	FBgn0085412	Length:	3090	Species:	Drosophila melanogaster
Sequence 2:	NP_001124171.1	Gene:	IPCEF1 / 26034	HGNCID:	21204	Length:	438	Species:	Homo sapiens

Alignment Length:	447	Identity:	94/447 - (21%)
Similarity:	168/447 - (37%)	Gaps:	144/447 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   358 ALKSPITKRPPSTP---VTLS---------------GWLHK---QGSDGLKVWRKRWFVLAEYCL 401
            ||:.|:.::|....   :|:|               |||:|   :||.....|:|.|.:|....|
Human    11 ALQVPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSSL 75

  Fly   402 YYYKGPEEEKLLGSVLLPSY---RVSACLPEDKIYRKFAFKCEHQNMRTYWLAADNSEAMMQWVR 463
            |:|.....||..|.|.||.:   |.|.|      .:|.|||..|..::|::.||:|.:.|..|:.
Human    76 YWYSNQMAEKADGFVNLPDFTVERASEC------KKKHAFKISHPQIKTFYFAAENVQEMNVWLN 134

  Fly   464 ALAAASLMQ-------------------------------------APSSGESEPSVN------- 484
            .|.:|.:.|                                     |..:..|.||::
Human   135 KLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFS 199

  Fly   485 -------------SSLNHSGENSDSGIHTLQSHPGKGQ----------PTPSS-------EN--- 516
                         |||:...::....:::|.:...:||          |.||.       ||
Human   200 SLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPITFAVQVHSPVPSEAGIHKALENSFV 264

  Fly   517 TGSSG---------GGSGSGQPLYANAPPKP--RRINDGGYSSPSPEHNEQQQQHPS--RRLMSP 568
            |..||         ..|.|....:...|.||  .:|.|...:..| |.:|.::.:.|  :..:||
Human   265 TSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKIMDKEETKVS-EDDEMEKLYKSLEQASLSP 328

  Fly   569 --TQQLYQQQQHQRSQQQQQQQPQQHHAIYDTRTGHVSTALQLQQAQQQYSLDHLEAQFQQQQLD 631
              .::...:::.::|..::.:.|..:..::..||  :::.|:.:        :| :.....|.||
Human   329 LGDRRPSTKKELRKSFVKRCKNPSINEKLHKIRT--LNSTLKCK--------EH-DLAMINQLLD 382

  Fly   632 MEEQIARLQQQRAAEEIYGEREMYMAKLMQQR--QGPNGTYPTQQQLLQAERRTPDA 686
            ..:..||..::.........:::|    .|||  ..|:.|..|.|:|    :::|.:
Human   383 DPKLTARKYREWKVMNTLLIQDIY----QQQRASPAPDDTDDTPQEL----KKSPSS 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmr	NP_001097775.2	PH_PEPP1_2_3	366..469	CDD:270068	37/126 (29%)
kmr	NP_001097775.2	PH	372..469	CDD:278594	36/117 (31%)
IPCEF1	NP_001124171.1	PH_CNK_mammalian-like	31..144	CDD:269962	36/118 (31%)
		PH	45..140	CDD:278594	34/100 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..226		7/81 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	274..308		7/33 (21%)
		CRAC domain	316..321		0/4 (0%)
		CRAC domain	340..349		1/8 (13%)
		Required for interaction with CYTH2. /evidence=ECO:0000269\|PubMed:22085542	390..438		10/50 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..438		9/29 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910