DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kmr and pob1

DIOPT Version :9

Sequence 1:	NP_001097775.2	Gene:	kmr / 5740131	FlyBaseID:	FBgn0085412	Length:	3090	Species:	Drosophila melanogaster
Sequence 2:	NP_596828.1	Gene:	pob1 / 2539992	PomBaseID:	SPBC1289.04c	Length:	871	Species:	Schizosaccharomyces pombe

Alignment Length:	1096	Identity:	217/1096 - (19%)
Similarity:	360/1096 - (32%)	Gaps:	374/1096 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   951 MSTQEIISKNEQFLRSASARLPKRSG------GMDDDYSAGNSTTTSPTGGAGASNSPQHNLDGE 1009
            |::|..:.....|...:|..||...|      .||:::..|........|..|...:....|..:
pombe     1 MASQRFVIALHSFPGKSSDELPLVEGRKYLLIKMDEEFGDGWWEGEDEQGNRGIFPASHVELISD 65

  Fly  1010 RKREESMKRLLEWKQRMLQSPLTRKGIQQGGSNMSAMSKLGSNPNILLASTAVASGARYAPQAGK 1074
            .:.:.|..|..:....:..:.:||..:   .|:.|..|:...:...|.::.:::|       :..
pombe    66 ERSDSSDSRRGKEDFSISTAEVTRSSL---SSSRSTSSRSDKDSEKLYSNNSLSS-------SHS 120

  Fly  1075 TVLVGNGNGTAQGAGNPPSASGIQRSRSESQANVGPGGVVYNNYSSD-DEAGTVDDDNLYSATAG 1138
            ::|    ||.......|...|.. .|...|....||..::.|..||| ....|:|.|  |:..:
pombe   121 SIL----NGPLDSLSKPSVPSNF-NSMFPSSKQEGPSPLLDNQPSSDLSNFNTIDAD--YNNAS- 177

  Fly  1139 RSSSSKTTTKATTSQAIVATTTAALAITNLGSS-KNLETPNQTETEATPSSSSTASSTKAKFQLK 1202
             :|:|...|.|:..:.:.|..:....||::.:: :|:    .|....||:.||
pombe   178 -ASTSAPATSASLKKVLSAEDSVRETITDIETALQNM----STSASRTPNDSS------------ 225

  Fly  1203 PILKVHEASKTRIIQVQPKHLEERPKLRLQLPKAMGNEEEQKQEDEEQENVEAEPVPILPKKTAP 1267
            |:                .::|.||...|.:.:.:.|
pombe   226 PL----------------PYIENRPASSLAVSEKIQN---------------------------- 246

  Fly  1268 KSPQNANYVPVYNNKLVSNY-ENMEFGKPIPESKIPHSNAAITDPEETPMLMQLKLFKEQQDQQK 1331
                    ||.::.:.|..: .|...|...|       |.|
pombe   247 --------VPNWSTEEVVEWLMNAGLGSVAP-------NFA------------------------ 272

  Fly  1332 QQQENEEEDLTPTAESKPIPGEEDMGA-PKVIKD-------QKLESNEEEQELEDEDDSTACEEY 1388
               |||            |.||..:|. ..|:|:       ::.|...:.|:|:|..:.:..|||
pombe   273 ---ENE------------ITGEILLGLDSNVLKELNITSFGKRFEVLRKIQQLKDSYEQSLYEEY 322

  Fly  1389 TDDDIDEALAQDDEDEAVVEAVESQELAEERELQQIYVNEPITPTDQQFDESHYLPM-------- 1445
            ..                                   ..|||: ..|..|.|..:|.
pombe   323 PQ-----------------------------------FAEPIS-VSQSSDSSSSIPKKSNDEAGG 351

  Fly  1446 TPKKVELGQPGVLTLVSATYAEEEEENHYV--------EMTKGIQDEDCRSN-------YEIMCL 1495
            :|.|....:||.              |.||        .::..|...|..|:       |.|..|
pombe   352 SPSKSSPTRPGF--------------NDYVNRPTSVMPSLSNMIVSPDLDSSPSTDWNQYVIPPL 402

  Fly  1496 ASTSSSAFKVTTKTEPVYMELAGVKASSAVP---ATEEAHCSSGRSTLKKCKKSGTETLKKKTKK 1557
            |:.||...|.|               .||||   :..:::..|..|.:.| :.|.|:::.
pombe   403 ATPSSRNSKST---------------QSAVPENVSRFDSNEPSATSPILK-RSSPTDSIS----- 446

  Fly  1558 RQGKDMPD-ILKPAKSALALASDSSDADDE----------SSRQQLEAKKLRSRSRFSLSDTFRP 1611
             |...:|. :.:|..|.   ::.|.|.|.|          ||:..|.|.              :|
pombe   447 -QNSGLPSRLTEPISSP---STSSIDVDKEGTSFPGLPYHSSKGNLYAP--------------QP 493

  Fly  1612 ASYYLGASTPLNNYAESSDSEILPPPPIPA-----------SPPPMEELKTEEI----------F 1655
            :|     :.|......:|:|..:||.|||:           |...:|||...:|          .
pombe   494 SS-----NVPTKFTGGASESSSVPPRPIPSAMKGKAPASAISIEALEELDPPKITTIDGESPSSI 553

  Fly  1656 SSEHYDTVKRKDSNGKVNLSYEQLP-------------------KMHASNTSLNLPKAVPSPTLK 1701
            ||....:...:.|:..|..|.|.:|                   |...:|.:..|.|..|..| |
pombe   554 SSRLPSSNLEQGSSSSVTKSPESMPDPSAKASSPVTSKGVSINEKSAVNNYATPLSKPQPKDT-K 617

  Fly  1702 SSRLSLPDHFTKVRMTPQRLLVPATPPQQHHAR---TLSDSNYSCQLTDTSSRTSSDLDLYRRRG 1763
            .|:|.    .|.|..:|...| ||:||.....:   ||.....|....:...:..|..|::   |
pombe   618 GSKLG----NTFVAPSPAASL-PASPPVGTELKTRPTLRSVASSPLNKEPIGKRKSKRDIF---G 674

  Fly  1764 QQQRCTSNNSLPLSS--ENESVE-------FRQRSDSELDRQRSRR-PLSQESISEIESLSEQFE 1818
            :|:...:..|..||:  ..|:::       .|:||| .....:||. .|....:|...||::..|
pombe   675 RQKVLPTGISEGLSNIPAKEAIKTADCHGWMRKRSD-RYGVWKSRYFVLKGTRLSYYHSLNDASE 738

  Fly  1819 ETL---SSHELDTYLSHLHLSTGQATPTSHLLNDANAAAGADILTNLIKPPKT--FRNAEDEEQH 1878
            :.|   :||.: |....:.||.|:.  ...|:..|..||.|.:   :..|||.  |....:||.|
pombe   739 KGLIDMTSHRV-TKTDDIVLSGGKT--AIKLIPPAPGAAKAAV---MFTPPKVHYFTCENNEELH 797

  Fly  1879 FYGNIHFLS------------STDSIQQLGEAGATALR------IIHSRNNSNIST 1916
            .:.:. ||.            :|..:..:..:.|..||      :|...|.:|:::
pombe   798 RWSSA-FLKATVERDMSVPVLTTSRMPTISLSKAKELRTRPPSLLIDDENEANLTS 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmr	NP_001097775.2	PH_PEPP1_2_3	366..469	CDD:270068
kmr	NP_001097775.2	PH	372..469	CDD:278594
pob1	NP_596828.1	SH3	5..61	CDD:214620	10/55 (18%)
		SAM	247..313	CDD:197735	20/111 (18%)
		SAM_BOI-like_fungal	248..311	CDD:188934	18/108 (17%)
		PH_Boi	700..807	CDD:270126	32/114 (28%)
		PH	701..806	CDD:278594	32/112 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2051
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030