Protein Alignment kmr and Plekha7

DIOPT Version :9

• Sequence 1: NP_001097775.2
• Gene: kmr / 5740131
• FlyBaseID: FBgn0085412
• Length: 3090
• Species: Drosophila melanogaster
• Sequence 2: XP_017177675.1
• Gene: Plekha7 / 233765
• MGIID: 2445094
• Length: 1359
• Species: Mus musculus
• Alignment Length: 1729
• Identity: 336/1729 - (19%)
• Similarity: 550/1729 - (31%)
• Gaps: 635/1729 - (36%)

  Fly   280 QQQQQHRH--KNDLQTPGSEHGTVYIQQNHPNHVVNQACQTQISAVKPKATPSS--EESSSNSTK 340
            ||....||  .....:..||:  |..::.||:          :|..:....|||  .|:|:..|.
Mouse    76 QQTTTFRHPVTGQFSSENSEY--VLREEPHPH----------MSKPERNQRPSSMVSETSTAGTT 128

  Fly   341 SPSHAPLDRK--KSAGSIQAL--KSPITKRPPSTPVTLSGWLHKQGSDGLKVWRKRWFVLAEYCL 401
            |...|....|  ||:..:.:.  :....:|..:.||.:.||||||.|.|:::|::||||||:|||
Mouse   129 STLEAKPGPKIVKSSSKVHSFGKRDQAIRRNLNVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCL 193

  Fly   402 YYYKGPEEEKLLGSVLLPSYRVSACLPEDKIYRKFAFKC-------------------EHQNMRT 447
            :|||...||.:|||:.||||.:|...|||:|.||::||.                   ||..|||
Mouse   194 FYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYSTTTAGSQMEHSGMRT 258

  Fly   448 YWLAADNSEAMMQWVRALAAASLMQAPSS-----GESEPSVNSSLNHSGENSDSGIHTLQSHPGK 507
            |:.:||..|.|..||||:..|:.:.:.||     .:.|.......||:....:.|      |.|.
Mouse   259 YYFSADTLEDMNAWVRAMNQAAQVLSRSSLRRDVDKVERQAMPQANHTDACQECG------HVGP 317

  Fly   508 GQPTPSSENTGSSGGGSGSGQPLYANAPPKPRRINDGGYSSPSPEHNEQQQQHPSRRLMSPTQQL 572
            |                        ::...|||    ||......:..:|::...|....|.
Mouse   318 G------------------------HSRDCPRR----GYEDSYGFNRREQEEERFRAQRDPL--- 351

  Fly   573 YQQQQHQRSQQQQQQQPQQHHAIYDTRTGHVSTALQLQQAQQQYSLDHLEAQFQQQQLDMEEQIA 637
              :.:..||:.:....|.:..|::....|    ..:.||||.|
Mouse   352 --EGRRDRSKARSPYLPAEEDALFVDLPG----GPRGQQAQPQ---------------------- 388

  Fly   638 RLQQQRAAEEIYGEREMYMAKLMQQRQGPNGTYPTQQQLLQAERRTPDAYGRSKQQRLFAAAAAA 702
              :.::.....||         :.::.|.||     .|.....|..|:.:.:.|      ...|.
Mouse   389 --RAEKNGVPPYG---------LGEQNGTNG-----YQRTAPPRANPEKHSQRK------TGLAQ 431

  Fly   703 ADYEDIYNMSQLAGGGGVPMSAQEALLQEAASYRRPLS-PPSYDGSKHVPAMPQRYTPNHLEASA 766
            |::   :..:|...|..:|:  .:.|.::..|  :||| |.:|.      ::|:  :..||..|:
Mouse   432 AEH---WTKAQKGDGRSLPL--DQTLPRQGPS--QPLSFPENYQ------SLPK--STRHLSGSS 481

  Fly   767 ADQLINTMDLRARTAAAIVRPHSADFLEYEARAEAAAAAAAAAVAQSQQESGRAPRPKSSLDINR 831
                                                                 :|.|::
Mouse   482 -----------------------------------------------------SPPPRN------ 487

  Fly   832 TPDSFYYSEASYADKMRKSALYLQSGGAGAAQPQQPGSYRTTGADFNSGVNTIGYENPYERAYKR 896
            .|..:.|::.      |.|.|.:.|        ::..::|       .|.....||....:.::.
Mouse   488 LPSDYKYAQD------RASHLKMSS--------EERRAHR-------DGTVWQLYEWQQRQQFRH 531

  Fly   897 QELLAEAQGGGASSMPRMSRSASQGRSVASQLQSPQQEDLPPLNVHPGSIFP---PSMSTQEIIS 958
            ....|.. |.|:.......||.|......|....|...|:||..  |...||   |....:.:..
Mouse   532 GSPTAPI-GAGSPEFTEQGRSRSLLEVPRSISVPPSPSDIPPPG--PPRPFPPRRPHTPAERVTV 593

  Fly   959 KNEQFLRSASARL---PKRSGGMDDDYSAGNST----TTSPTGGAGASNSPQHNLDGERKREESM 1016
            |..:..||....|   |:::.|    ::|.||:    .:.|:.|.........:|.|  |..|.:
Mouse   594 KPPEQRRSVDISLGGSPRKARG----HAAKNSSHVDRRSMPSMGYMTHTVSAPSLHG--KSLEEL 652

  Fly  1017 KRLLEWKQRMLQSPLTRKGIQQGGSNMSAMSKLGSNPNILLASTAVASGARYAPQAGKTVL---- 1077
            ..||...||                   ..|||.|..|..:...........|.||..|.|
Mouse   653 SLLLTRLQR-------------------HQSKLASVRNFAVGQLLHHYLTFPACQADDTYLQLKK 698

  Fly  1078 --------VGNGNGTAQGAGNPPSASGIQRSRSESQANVGPGGVVYNNYSSDDEAGTVDDDNLYS 1134
                    :.|         |.|..:.:.:...:|.....|
Mouse   699 DLEYLDLKIKN---------NEPLINVLYKVLKKSARGCRP------------------------ 730

  Fly  1135 ATAGRSSSSKTTTKATTSQAI-VATTTAALAITNLGSSKNLETPNQTETEATPSSSSTASSTKAK 1198
               |||.:.:...|..:.:.: :|.:...:.::.......:....:.:..|...:         |
Mouse   731 ---GRSMTGRDLLKDRSLKPMKIAESDIDVKLSIFCEQDRILQDLEDKIRALKEN---------K 783

  Fly  1199 FQLKPILKV-HEASKTRIIQVQPKHLEE---------------RPKL-------------RLQLP 1234
            .||:.:|:| |.  :|...:.||:|||:               |.:|             .|:|.
Mouse   784 DQLESVLEVLHR--QTEQYRDQPQHLEKITCQQRLLQEDLVHIRAELCRESTEMENAWNEYLKLE 846

  Fly  1235 KAMGNEEEQKQEDEEQ-----------------------------------------ENVEAEPV 1258
            |   :.|:.||..:||                                         :|.|.:.|
Mouse   847 K---DVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVMAGLSANKENYRVLVGSVKNPERKTV 908

  Fly  1259 PILPKKTAPK-SPQNANYVPVYNNKLVSNYENMEFGKPIPESKIPHSNAAITDPEETPMLMQLKL 1322
            |:.|..:.|. ||..:                    ||..:...|      |.|..||  ::::|
Mouse   909 PLFPHPSVPSLSPTES--------------------KPALQPSPP------TSPVRTP--LEVRL 945

  Fly  1323 FKEQQ----------------------DQQKQQQENE------------EEDLTPTAESKPIPGE 1353
            |.:.|                      .:.|.|.|:|            .||..|..  .|:|.|
Mouse   946 FPQLQTYVPYRPHPPQLRKVMSPLQSPTKAKPQAEDEAPPRPPLPELYSPEDQPPAV--PPLPRE 1008

  Fly  1354 EDMGAPKVIKDQKLESNEEEQELEDEDDSTACEEYTDDDIDEALAQDDEDEAVVEAVESQELAEE 1418
            ..:.....::..|.:|:|.:::.|.       .:..:.|:               .||.:....|
Mouse  1009 ATIIRHTSVRGLKRQSDERKRDREQ-------GQCVNGDL---------------KVELRSYVSE 1051

  Fly  1419 RELQQIYVNEPITPTDQQFDESHYLPMTPKKVELGQPGVLTLV--SATYAEEEEENHYVEMTKGI 1481
            .||..:..:.|.........||.|..:..:    |..|..:.:  |:|.|.      ||.:.:|:
Mouse  1052 PELASLSGDVPQPSLSLVGSESRYQTLPGR----GLSGSTSRLQQSSTIAP------YVTLRRGL 1106

  Fly  1482 QDEDCRSNYEIMCLASTSSSAFKVTTKTEPVYMELAGVKASSAVPATEEAHCSSGRSTLKKCKKS 1546
            .             |..||:.|     :.|                                 ||
Mouse  1107 N-------------AENSSATF-----SRP---------------------------------KS 1120

  Fly  1547 GTETLKKKTKKRQGKDMPDILKPAKSALALASDSSDADDESSRQQLEAKK------LRSRSRFSL 1605
            ..|.|.....:| ||                        .|:.:|||..|      :|.|.| :|
Mouse  1121 ALERLYSGDHQR-GK------------------------MSAEEQLERMKRHQKALVRERKR-TL 1159

  Fly  1606 SD---TFRPASYYLGASTPLNNYAESSDSEILPPPPIPASPPPMEELKTEEIFSSEHYDTVKRKD 1667
            |.   |...::.||  |.||                    |..:...|.|:.|..:..:...:.|
Mouse  1160 SQGEKTGLLSARYL--SQPL--------------------PGDLGSWKREQEFDLQLLERAAQGD 1202

  Fly  1668 SNGKVN--LSYEQLPKM----HASNTSLNLPKAVPSPTLKSSRLSLPDHFTKVRMTPQRLLVPAT 1726
            ...|..  |..:..|.|    ...:..|::.:.:..|    .::|:|:.:.:        |.|..
Mouse  1203 RKDKEEGWLKVQATPVMELDLEPQDYDLDISRELSKP----EKVSIPERYVE--------LDPEE 1255

  Fly  1727 PP----------QQHHARTLSDSNYSCQLTDTSSRTSSDLDLYRRRGQQQRCTSNNSLPLSSENE 1781
            ||          :....|.:...:..|.|.......:|..||..:..:|:|.. |.|..|:|| .
Mouse  1256 PPSLEELQARYQKAEKIRNILARSSMCNLQPLGQDRNSLADLDSQLQEQERII-NISYALASE-A 1318

  Fly  1782 SVEFRQRSDSELDRQRSRRPLSQESISEIESLSEQFEET 1820
            |...:|.:..:|.....:.|||..::.....||.....|
Mouse  1319 SKRSKQVAVQQLALLPPKAPLSSRTVPPYPPLSNGLHYT 1357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kmr	NP_001097775.2	PH_PEPP1_2_3	366..469	CDD:270068	56/121 (46%)
		PH	372..469	CDD:278594	54/115 (47%)
Plekha7	XP_017177675.1	WW	10..39	CDD:366073
		WW	55..84	CDD:366073	3/7 (43%)
		PH_PEPP1_2_3	158..280	CDD:270068	56/121 (46%)
		Smc	<692..>894	CDD:224117	35/251 (14%)
		PHA03247	<903..1009	CDD:223021	26/135 (19%)
		PRK10263	<912..>1118	CDD:236669	50/285 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	115	1.000	Domainoid score	I6000
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003396
OrthoInspector	1	1.000	-	-		otm43685
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12752
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.100