DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kmr and Rasgrf1

DIOPT Version :9

Sequence 1:	NP_001097775.2	Gene:	kmr / 5740131	FlyBaseID:	FBgn0085412	Length:	3090	Species:	Drosophila melanogaster
Sequence 2:	NP_001164002.1	Gene:	Rasgrf1 / 192213	RGDID:	620395	Length:	1244	Species:	Rattus norvegicus

Alignment Length:	1511	Identity:	261/1511 - (17%)
Similarity:	452/1511 - (29%)	Gaps:	610/1511 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   373 TLSGWLHKQGSDGLKVWRKRWFVLAEYCLYYYKGPEEEKLLGSVLL--------PS-YRVSACLP 428
            |..|:|.|:.||..| |:.:||.|.:..|:|::.....:..|..||        || .|.::...
  Rat    24 TRKGYLSKRSSDNPK-WQTKWFALLQNLLFYFESDSSSRPSGLYLLEGSICKRMPSPKRGTSSKE 87

  Fly   429 EDKIYRKFAFKCEHQNMRTYWLAADNSEAMMQWVRALAAASLMQAPSSGESEPSVNSSLNHSGEN 493
            .||.:..|.....:.:.::..|..|:|:...:||.|:|.||
  Rat    88 SDKQHHYFTVNFSNDSQKSLELRTDDSKDCDEWVAAIARAS------------------------ 128

  Fly   494 SDSGIHTLQSHPGKGQPTPSSENTGSSGGGSGSGQPLYANAPPKPRRINDGGYSSPSPEHNEQQQ 558
                                                                |...:.||
  Rat   129 ----------------------------------------------------YKILATEH----- 136

  Fly   559 QHPSRRLMSPTQQLYQQQQHQRSQQQQQQQPQQHHAIYDTRTGHVSTALQLQQAQQQYSLDHLEA 623
                ..||.....|.|..:.:::..:|.:|                   ||:..:.:  ::.|:|
  Rat   137 ----EALMQKYLHLLQVVETEKTVAKQLRQ-------------------QLEDGEVE--IERLKA 176

  Fly   624 Q----------FQQQQL----DMEEQIARLQQQRAAEEIYGEREMYMAKLMQQRQGPNGTYPTQQ 674
            :          .|..||    |.:..|.::::.::          ::...:.:|:..|
  Rat   177 EIANLIKDNERIQSNQLVAPEDEDSDIKKIKKVQS----------FLRGWLCRRKWKN------- 224

  Fly   675 QLLQAERRTPDAYG-RSKQQRLFAAAAAAADYEDIYNMSQLAGGGGVPMSAQEALLQEAASYRRP 738
             ::|...|:|.|.. |.:.|.:|:...|.|:|  :..:..|......|       |:.|||.::|
  Rat   225 -IIQDYIRSPHADSMRKRNQVVFSMLEAEAEY--VQQLHILVNNFLRP-------LRMAASSKKP 279

  Fly   739 LSPPSYDGSKHVPAMPQRYTPNHLEASAADQLINTMDLRARTAAAIVRPHSADFLEYEARAEAAA 803
              |.::|.                        ::::.|.:.|   |:..|...:...:||..:..
  Rat   280 --PITHDD------------------------VSSIFLNSET---IMFLHQIFYQGLKARIASWP 315

  Fly   804 AAAAAAVAQSQQESGRAPRPKSSLDINRTPDSFYYSEASYADKMRKSALYLQSGGAGAAQPQQPG 868
            ....|.:                .|| ..|....|.|.     :|.....||.    .|..:|
  Rat   316 TLVLADL----------------FDI-LLPMLNIYQEF-----VRNHQYSLQI----LAHCKQ-- 352

  Fly   869 SYRTTGADFNSGVNTIGYENPYERAYKRQELLAEAQGGGASSMPRMSRSASQGRSVASQLQSPQQ 933
                              ...:::..|:.|                ::...:.|::.:.|..|..
  Rat   353 ------------------NRDFDKLLKQYE----------------AKPDCEERTLETFLTYPMF 383

  Fly   934 EDLPP--LNVHPGSIFPPSMSTQEIISKNEQFLRSASARLPKRSGGMDDDYSAGNSTTTSPTGGA 996
            : :|.  |.:|......|    .|.:.:|.  |..|.::|.:.|..|.|:.|
  Rat   384 Q-IPRYILTLHELLAHTP----HEHVERNS--LDYAKSKLEELSRVMHDEVS------------- 428

  Fly   997 GASNSPQHNLDGERKREESMKRLLEWKQ------RMLQSPLTRKG-IQQGGSNMSAMSKLGSNPN 1054
             .:.:.:.||..||...|..:.||:..|      .::|.|::.|| |.:|.....::.|.|....
  Rat   429 -ETENIRKNLAIERMITEGCEILLDTSQTFVRQGSLIQVPMSEKGKINKGRLGSLSLKKEGERQC 492

  Fly  1055 ILLASTAVASGARYAPQAGKTVLVGNGNGTAQGAGNPPSASGIQRSRSESQANVGPGGVVY---- 1115
            .|.:.              ..::...|:|                    |:.::...||:.
  Rat   493 FLFSK--------------HLIICTRGSG--------------------SKLHLTKNGVISLIDC 523

  Fly  1116 ------NNYSSDDEAGTVD--DDNLY-------SATAGRSSSSKTTTKATTSQAIVATTTA---A 1162
                  .|...|.:...||  |..::       ..|....:||:....|.||..|......   .
  Rat   524 TLLDDPENMDDDGKGQEVDHLDFKIWVEPKDSPPFTVILVASSRQEKAAWTSDIIQCVDNIRCNG 588

  Fly  1163 LAITNLGSSKNLETPNQTETEAT-------PSSSSTASSTKAKFQLKPILKVHEASKTRIIQVQP 1220
            |.:.....:..:..|...:::|:       ...|.|.:|.|       :|::..||..|:
  Rat   589 LMMNAFEENSKVTVPQMIKSDASLYCDDVDIRFSKTMNSCK-------VLQIRYASVERL----- 641

  Fly  1221 KHLEERPKLR---------------------LQLPKAMGNEEEQKQEDEEQENVEAEPVPILPKK 1264
              ||....||                     :.|.|.:              ::..:|:..:|.:
  Rat   642 --LERLTDLRFLSIDFLNTFLHSYRVFTDAVVVLDKLI--------------SIYKKPITAIPAR 690

  Fly  1265 T-----------------APKSPQNANYV------------PVYNNKLVSN-------------- 1286
            :                 |||||:.:...            ||...||..|
  Rat   691 SLELLFSSSHNTKLLYGDAPKSPRASRKFSSPPPLAIGTSSPVRRRKLSLNIPIITGGKALELAS 755

  Fly  1287 -------YENME-----FGK-PIPESKIPHSNAAITDPEETPM--LMQLKLF-KEQQDQQKQQQE 1335
                   |.|:.     ||| .:..||:..:::....|||..|  |.:...| |...|..|::.:
  Rat   756 LGCPSDGYTNIHSPISPFGKTTLDTSKLCVASSLTRTPEEIDMTTLEESSGFRKPTSDILKEESD 820

  Fly  1336 NEEEDLTPTAESKPIPGEEDMGAPKVIKDQKLESNEEEQELE----DEDDSTACEEYTDDDIDE- 1395
            :::.|:..|..|.|.|              |...|...||..    :......|.:..|.:...
  Rat   821 DDQSDVDDTEVSPPTP--------------KSFRNRITQEFPLFNYNSGIMMTCRDLMDSNRSPL 871

  Fly  1396 --------ALAQDDEDEAVVEAVESQELA------EERELQQIYV-------------NEPITPT 1433
                    |.|..:|..|..|......||      ::|.:.:.:|             ...:|..
  Rat   872 SATSAFAIATAGANESPANKEIYRRMSLANTGYSSDQRNIDKEFVIRRAATNRVLNVLRHWVTKH 936

  Fly  1434 DQQFDESHYLPM-----------TPKKVELGQPGVLTLVSATYAEEEEENH-----YVEMTKGIQ 1482
            .|.|:....|..           .|..:...:.....::.....||..|||     .:.||:|::
  Rat   937 SQDFETDDLLKYKVICFLEEVMHDPDLLPQERKAAANIMRTLTQEEITENHSMLDELLLMTEGVK 1001

  Fly  1483 DEDCRSNYEIMCLASTSSSAFKVTTKTEPVYMELAG---VKA----------------------- 1521
            .|.. .|:..|.:|...:....:..|:.| |.|..|   :||
  Rat  1002 TEPF-ENHSAMEIAEQLTLLDHLVFKSIP-YEEFFGQGWMKADKNERTPYIMKTTRHFNHISNLI 1064

  Fly  1522 SSAVPATEEAHCSSGRSTLKK-------CK----------------KSGTETLKKKTKK--RQGK 1561
            :|.:...||.  |:..||::|       |:                :|....|||...|  :|.|
  Rat  1065 ASEILRNEEV--SARASTIEKWVAVADICRCLHNYNAVLEITSSINRSAIFRLKKTWLKVSKQTK 1127

  Fly  1562 DMPDILKPAKSALALASDSSDADDESSRQQLEAKKLRSRSRF-SLSDTFR----PASYYLG---- 1617
            .:.|.|:                          |.:.|..|| :|.:|.|    |...|||
  Rat  1128 SLFDKLQ--------------------------KLVSSDGRFKNLRETLRNCDPPCVPYLGMYLT 1166

  Fly  1618 ------ASTPLNNYAE 1627
                  ..||  ||.|
  Rat  1167 DLAFLEEGTP--NYTE 1180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmr	NP_001097775.2	PH_PEPP1_2_3	366..469	CDD:270068	29/104 (28%)
kmr	NP_001097775.2	PH	372..469	CDD:278594	29/104 (28%)
Rasgrf1	NP_001164002.1	PH-like	19..154	CDD:302622	38/215 (18%)
		PH	24..129	CDD:278594	31/181 (17%)
		RhoGEF	244..425	CDD:214619	46/287 (16%)
		PH-like	431..580	CDD:302622	34/182 (19%)
		PH	476..581	CDD:278594	21/138 (15%)
		RasGEF_N	632..>680	CDD:279012	9/68 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	707..730		5/22 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	800..840		11/53 (21%)
		REM	<909..978	CDD:295342	7/68 (10%)
		RasGEF	1005..1241	CDD:214539	43/208 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910