DRSC/TRiP Functional Genomics Resources

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Protein Alignment kmr and PLEKHA7

DIOPT Version :9

Sequence 1:NP_001097775.2 Gene:kmr / 5740131 FlyBaseID:FBgn0085412 Length:3090 Species:Drosophila melanogaster
Sequence 2:XP_024304124.1 Gene:PLEKHA7 / 144100 HGNCID:27049 Length:1365 Species:Homo sapiens


Alignment Length:1685 Identity:336/1685 - (19%)
Similarity:572/1685 - (33%) Gaps:562/1685 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   278 LQQQQQQHRHKNDLQTPGSEHGTVYIQQNHPNHVVNQACQTQISAVKPKATPSS--EESSSNSTK 340
            :...||....::.:....|...:.:|.|..||..:::..:.|        .|||  .|:|:..|.
Human    73 IDHNQQTTAFRHPVTGQFSPENSEFILQEEPNPHMSKQDRNQ--------RPSSMVSETSTAGTA 129

  Fly   341 SPSHAPLDRK--KSAGSIQAL--KSPITKRPPSTPVTLSGWLHKQGSDGLKVWRKRWFVLAEYCL 401
            |...|....|  ||:..:.:.  :....:|.|:.||.:.||||||.|.|:::|::||||||:|||
Human   130 STLEAKPGPKIIKSSSKVHSFGKRDQAIRRNPNVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCL 194

  Fly   402 YYYKGPEEEKLLGSVLLPSYRVSACLPEDKIYRKFAFKCEH-------------------QNMRT 447
            :|||...||.:|||:.||||.:|...|||:|.||::||..|                   ..|||
Human   195 FYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYNSSTAGSQAEQSGMRT 259

  Fly   448 YWLAADNSEAMMQWVRALAAASLMQAPSSGESEPSVNSSLNHSGENSDSGIHTLQSHPGKGQPTP 512
            |:.:||..|.|..||||:..|:.:.:          .|||....|..:.            |..|
Human   260 YYFSADTQEDMNAWVRAMNQAAQVLS----------RSSLKRDMEKVER------------QAVP 302

  Fly   513 SSENTGS--SGGGSGSGQPLYANAPPKPRRINDGGYSSPSPEHNEQQ-QQHPSRRLMSPTQQLYQ 574
            .:.:|.|  ..|..|.|     :....|.|.:|   ...:.|..||: :|:.|:|  .|.     
Human   303 QANHTESCHECGRVGPG-----HTRDCPHRGHD---DIVNFERQEQEGEQYRSQR--DPL----- 352

  Fly   575 QQQHQRSQQQQQQQPQQHHAIY-DTRTGHVSTALQLQQAQQQYSLDHLEAQFQQQQLDMEEQIAR 638
            :.:..||:.:....|.:..|:: |..||......|.|:|::.   ..|.|.:...:.:......|
Human   353 EGKRDRSKARSPYSPAEEDALFMDLPTGPRGQQAQPQRAEKN---GMLPASYGPGEQNGTGGYQR 414

  Fly   639 LQQQRAAEEIYGEREMYMAKL---MQQRQGPNGTYPTQQQLLQAERRTPDAYGRSKQQRLFAAAA 700
            ....|...|.:.:|:..:|::   .:.::|.:.:.|..|.|   .|:.|   |:|        .:
Human   415 AFPPRTNPEKHSQRKSNLAQVEHWARAQKGDSRSLPLDQTL---PRQGP---GQS--------LS 465

  Fly   701 AAADYEDIYNMSQLAGGGGVPMSAQEALLQEAASYRRPLSPPSYDGSKHVPAMPQRYT---PNHL 762
            ...:|:.:...::...||..|                   ||     :::|: ..:|.   .:||
Human   466 FPENYQTLPKSTRHPSGGSSP-------------------PP-----RNLPS-DYKYAQDRASHL 505

  Fly   763 EASAADQLINTMDLRARTAAAIVRPHSADFLEYEARAEAAAAAAAAAVAQSQQESGRAPRPKSSL 827
            :.|:.::       ||.....:.:     ..|::.|.:....:..|.:.....|.....|.:|.|
Human   506 KMSSEER-------RAHRDGTVWQ-----LYEWQQRQQFRHGSPTAPICLGSPEFTDQGRSRSML 558

  Fly   828 DINRTPDSFYYSEASYADKMRKSALYLQSGGAGAAQPQQPGSYRTTGADFNSGVNTIGYENPYER 892
            ::.|                                                             
Human   559 EVPR------------------------------------------------------------- 562

  Fly   893 AYKRQELLAEAQGGGASSMPRMSRSASQGRSVASQLQSPQQEDLPPLNVHPGSIFP---PSMSTQ 954
                           :.|:|                  |...|:||..  |..:||   |....:
Human   563 ---------------SISVP------------------PSPSDIPPPG--PPRVFPPRRPHTPAE 592

  Fly   955 EIISKNEQFLRSASARL---PKRSGGMDDDYSAGNSTTTSPTGGAGASNSPQHNLDGERKREESM 1016
            .:..|.....||....|   |:|:.|.....|:.....:.|:.|.........:|.|:...|.|:
Human   593 RVTVKPPDQRRSVDISLGDSPRRARGHAVKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSLEELSL 657

  Fly  1017 KRLLEWKQRMLQSPLTRKGIQQGGSNMSAMSKLGSNPNILLASTAVASGARYAPQAGKTVL---- 1077
            .             |||....|        :||.|..|..::............||..|.|    
Human   658 L-------------LTRLRRHQ--------AKLASVRNFAISQLLQHQLTFPTCQADDTYLQLKK 701

  Fly  1078 --------VGNGNGTAQGAGNPPSASGIQRSRSESQANVGPGGVVYNNYSSDDEAGTVDDDNLYS 1134
                    :.|         |.|..:.:.:...:|.....|                        
Human   702 DLEYLDLKIKN---------NEPLINVLYKVLKKSARGCRP------------------------ 733

  Fly  1135 ATAGRSSSSKTTTKATTSQAI-VATTTAALAITNLGSSKNLETPNQTETEATPSSSSTASSTKAK 1198
               .||.:.:...|..:.:.: :|.:...:.::.......:....:.:..|...:         |
Human   734 ---RRSMTGRDLLKDRSLKPVKIAESDTDVKLSIFCEQDRVLQDLEDKIRALKEN---------K 786

  Fly  1199 FQLKPILKV-HEASKTRIIQVQPKHLEE---RPKL--------RLQLPK-------------AMG 1238
            .||:.:|:| |...:.  .:.||:|||:   :.||        |.:|.:             .:.
Human   787 DQLESVLEVLHRQMEQ--YRDQPQHLEKIAYQQKLLQEDLVHIRAELSRESTEMENAWNEYLKLE 849

  Fly  1239 NEEEQ-KQEDEEQ--------------------ENVEA------EPVPILPKKTAPKSPQNANYV 1276
            |:.|| ||..:||                    |:|.|      |...||.:..  |:|:... |
Human   850 NDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVTAGLSANKENFRILVESV--KNPERKT-V 911

  Fly  1277 PVYNNKLVSNYENMEFGKPIPESKIPHSNAAITDPEETPMLMQLKLFKEQQDQQKQQQENEEEDL 1341
            |::.:..|.:....| .||.|:...|      |.|..||  ::::||.:.|..            
Human   912 PLFPHPPVPSLSTSE-SKPPPQPSPP------TSPVRTP--LEVRLFPQLQTY------------ 955

  Fly  1342 TPTAESKPIPGEEDMGAPKVIK-DQKLESNEEEQELEDEDDS----TACEEYTDDDIDEALAQDD 1401
               ...:|.|       |::.| ...|:|..:.:....||::    ...|.|:.:|...|:....
Human   956 ---VPYRPHP-------PQLRKVTSPLQSPTKAKPKVQEDEAPPRPPLPELYSPEDQPPAVPPLP 1010

  Fly  1402 EDEAVVEAV-------ESQELAEERELQQI-----------YVNEPITPTDQQFDESHYLPMTPK 1448
            .:..::...       :|.|...:|||.|.           ||:||              .:...
Human  1011 REATIIRHTSVRGLKRQSDERKRDRELGQCVNGDSRVELRSYVSEP--------------ELATL 1061

  Fly  1449 KVELGQPGVLTLVSATYAEEEEENHYVEMT-KGIQDEDCRSNYEIMCLASTSSSAFKVTTKTEPV 1512
            ..::.||. |.||.       .|:.|..:. :|:.....|       |..:|:.|..||.:    
Human  1062 SGDMAQPS-LGLVG-------PESRYQTLPGRGLSGSTSR-------LQQSSTIAPYVTLR---- 1107

  Fly  1513 YMELAGVKASSAVPATEEAHCSSGRSTLKKCKKSGTETLKKKTKKRQGKDMPDILKPAKSALALA 1577
                .|:.|.|:            ::|..: .||..|.|.....:| ||                
Human  1108 ----RGLNAESS------------KATFPR-PKSALERLYSGDHQR-GK---------------- 1138

  Fly  1578 SDSSDADDESSRQQLEAKKL---RSRSRFSLSDTFRPASYYLGASTPLNNYAESSDSEILPPPPI 1639
               ..|:::..|.:...|.|   |.|:......|..|:|.||  |.||                 
Human  1139 ---MSAEEQLERMKRHQKALVRERKRTLGQGERTGLPSSRYL--SRPL----------------- 1181

  Fly  1640 PASPPPMEELKTEEIFSSEHYDTV-----KRKDSNGKVNLSYEQLP----KMHASNTSLNLPKAV 1695
               |..:...|.|:.|..:..:.|     |.|:.||.  |..:.:|    .:...:..|::.:.:
Human  1182 ---PGDLGSWKREQDFDLQLLERVVQGEKKDKEENGW--LKVQAMPVTELDLEPQDYDLDISREL 1241

  Fly  1696 PSPTLKSSRLSLPDHFTKVRMTPQRLLVPATPP----------QQHHARTLSDSNYSCQLTDTSS 1750
            ..|    .::|:|:.:.:        |.|..||          :....|.:...:..|.|..||.
Human  1242 SKP----EKVSIPERYVE--------LDPEEPPSLEELQARYRKAEKIRNILARSSMCNLQPTSG 1294

  Fly  1751 R---TSSDLDLYRRRGQQQRCTSNNSLPLSSENESVEFRQRSDSELDRQRSRRPLSQESI 1807
            :   :.:||||   :.|:|....|.|..|:|| .|...:|.:..:|.....:.|||..::
Human  1295 QDQNSVADLDL---QLQEQERIINISYALASE-ASQRSKQVAAQQLALLPPKGPLSSRTV 1350

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kmrNP_001097775.2 PH_PEPP1_2_3 366..469 CDD:270068 56/121 (46%)
PH 372..469 CDD:278594 53/115 (46%)
PLEKHA7XP_024304124.1 WW 11..40 CDD:306827
WW 56..85 CDD:306827 2/11 (18%)
PH_PEPP1_2_3 159..281 CDD:270068 56/121 (46%)
NESP55 <299..460 CDD:115071 39/181 (22%)
DUF1640 779..905 CDD:311647 29/138 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 114 1.000 Domainoid score I6075
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003396
OrthoInspector 1 1.000 - - otm41640
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR12752
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
55.100

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