Protein Alignment kmr and PLEKHA7

DIOPT Version :10

• Sequence 1: NP_001097775.2
• Gene: kmr / 5740131
• FlyBaseID: FBgn0085412
• Length: 3090
• Species: Drosophila melanogaster
• Sequence 2: XP_047282382.1
• Gene: PLEKHA7 / 144100
• HGNCID: 27049
• Length: 1365
• Species: Homo sapiens
• Alignment Length: 1685
• Identity: 336/1685 - (19%)
• Similarity: 572/1685 - (33%)
• Gaps: 562/1685 - (33%)

  Fly   278 LQQQQQQHRHKNDLQTPGSEHGTVYIQQNHPNHVVNQACQTQISAVKPKATPSS--EESSSNSTK 340
            :...||....::.:....|...:.:|.|..||..:::..:.|        .|||  .|:|:..|.
Human    73 IDHNQQTTAFRHPVTGQFSPENSEFILQEEPNPHMSKQDRNQ--------RPSSMVSETSTAGTA 129

  Fly   341 SPSHAPLDRK--KSAGSIQAL--KSPITKRPPSTPVTLSGWLHKQGSDGLKVWRKRWFVLAEYCL 401
            |...|....|  ||:..:.:.  :....:|.|:.||.:.||||||.|.|:::|::||||||:|||
Human   130 STLEAKPGPKIIKSSSKVHSFGKRDQAIRRNPNVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCL 194

  Fly   402 YYYKGPEEEKLLGSVLLPSYRVSACLPEDKIYRKFAFKCEH-------------------QNMRT 447
            :|||...||.:|||:.||||.:|...|||:|.||::||..|                   ..|||
Human   195 FYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYNSSTAGSQAEQSGMRT 259

  Fly   448 YWLAADNSEAMMQWVRALAAASLMQAPSSGESEPSVNSSLNHSGENSDSGIHTLQSHPGKGQPTP 512
            |:.:||..|.|..||||:..|:.:.:          .|||....|..:.            |..|
Human   260 YYFSADTQEDMNAWVRAMNQAAQVLS----------RSSLKRDMEKVER------------QAVP 302

  Fly   513 SSENTGS--SGGGSGSGQPLYANAPPKPRRINDGGYSSPSPEHNEQQ-QQHPSRRLMSPTQQLYQ 574
            .:.:|.|  ..|..|.|     :....|.|.:|   ...:.|..||: :|:.|:|  .|.
Human   303 QANHTESCHECGRVGPG-----HTRDCPHRGHD---DIVNFERQEQEGEQYRSQR--DPL----- 352

  Fly   575 QQQHQRSQQQQQQQPQQHHAIY-DTRTGHVSTALQLQQAQQQYSLDHLEAQFQQQQLDMEEQIAR 638
            :.:..||:.:....|.:..|:: |..||......|.|:|::.   ..|.|.:...:.:......|
Human   353 EGKRDRSKARSPYSPAEEDALFMDLPTGPRGQQAQPQRAEKN---GMLPASYGPGEQNGTGGYQR 414

  Fly   639 LQQQRAAEEIYGEREMYMAKL---MQQRQGPNGTYPTQQQLLQAERRTPDAYGRSKQQRLFAAAA 700
            ....|...|.:.:|:..:|::   .:.::|.:.:.|..|.|   .|:.|   |:|        .:
Human   415 AFPPRTNPEKHSQRKSNLAQVEHWARAQKGDSRSLPLDQTL---PRQGP---GQS--------LS 465

  Fly   701 AAADYEDIYNMSQLAGGGGVPMSAQEALLQEAASYRRPLSPPSYDGSKHVPAMPQRYT---PNHL 762
            ...:|:.:...::...||..|                   ||     :::|: ..:|.   .:||
Human   466 FPENYQTLPKSTRHPSGGSSP-------------------PP-----RNLPS-DYKYAQDRASHL 505

  Fly   763 EASAADQLINTMDLRARTAAAIVRPHSADFLEYEARAEAAAAAAAAAVAQSQQESGRAPRPKSSL 827
            :.|:.::       ||.....:.:     ..|::.|.:....:..|.:.....|.....|.:|.|
Human   506 KMSSEER-------RAHRDGTVWQ-----LYEWQQRQQFRHGSPTAPICLGSPEFTDQGRSRSML 558

  Fly   828 DINRTPDSFYYSEASYADKMRKSALYLQSGGAGAAQPQQPGSYRTTGADFNSGVNTIGYENPYER 892
            ::.|
Human   559 EVPR------------------------------------------------------------- 562

  Fly   893 AYKRQELLAEAQGGGASSMPRMSRSASQGRSVASQLQSPQQEDLPPLNVHPGSIFP---PSMSTQ 954
                           :.|:|                  |...|:||..  |..:||   |....:
Human   563 ---------------SISVP------------------PSPSDIPPPG--PPRVFPPRRPHTPAE 592

  Fly   955 EIISKNEQFLRSASARL---PKRSGGMDDDYSAGNSTTTSPTGGAGASNSPQHNLDGERKREESM 1016
            .:..|.....||....|   |:|:.|.....|:.....:.|:.|.........:|.|:...|.|:
Human   593 RVTVKPPDQRRSVDISLGDSPRRARGHAVKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSLEELSL 657

  Fly  1017 KRLLEWKQRMLQSPLTRKGIQQGGSNMSAMSKLGSNPNILLASTAVASGARYAPQAGKTVL---- 1077
            .             |||....|        :||.|..|..::............||..|.|
Human   658 L-------------LTRLRRHQ--------AKLASVRNFAISQLLQHQLTFPTCQADDTYLQLKK 701

  Fly  1078 --------VGNGNGTAQGAGNPPSASGIQRSRSESQANVGPGGVVYNNYSSDDEAGTVDDDNLYS 1134
                    :.|         |.|..:.:.:...:|.....|
Human   702 DLEYLDLKIKN---------NEPLINVLYKVLKKSARGCRP------------------------ 733

  Fly  1135 ATAGRSSSSKTTTKATTSQAI-VATTTAALAITNLGSSKNLETPNQTETEATPSSSSTASSTKAK 1198
               .||.:.:...|..:.:.: :|.:...:.::.......:....:.:..|...:         |
Human   734 ---RRSMTGRDLLKDRSLKPVKIAESDTDVKLSIFCEQDRVLQDLEDKIRALKEN---------K 786

  Fly  1199 FQLKPILKV-HEASKTRIIQVQPKHLEE---RPKL--------RLQLPK-------------AMG 1238
            .||:.:|:| |...:.  .:.||:|||:   :.||        |.:|.:             .:.
Human   787 DQLESVLEVLHRQMEQ--YRDQPQHLEKIAYQQKLLQEDLVHIRAELSRESTEMENAWNEYLKLE 849

  Fly  1239 NEEEQ-KQEDEEQ--------------------ENVEA------EPVPILPKKTAPKSPQNANYV 1276
            |:.|| ||..:||                    |:|.|      |...||.:..  |:|:... |
Human   850 NDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVTAGLSANKENFRILVESV--KNPERKT-V 911

  Fly  1277 PVYNNKLVSNYENMEFGKPIPESKIPHSNAAITDPEETPMLMQLKLFKEQQDQQKQQQENEEEDL 1341
            |::.:..|.:....| .||.|:...|      |.|..||  ::::||.:.|..
Human   912 PLFPHPPVPSLSTSE-SKPPPQPSPP------TSPVRTP--LEVRLFPQLQTY------------ 955

  Fly  1342 TPTAESKPIPGEEDMGAPKVIK-DQKLESNEEEQELEDEDDS----TACEEYTDDDIDEALAQDD 1401
               ...:|.|       |::.| ...|:|..:.:....||::    ...|.|:.:|...|:....
Human   956 ---VPYRPHP-------PQLRKVTSPLQSPTKAKPKVQEDEAPPRPPLPELYSPEDQPPAVPPLP 1010

  Fly  1402 EDEAVVEAV-------ESQELAEERELQQI-----------YVNEPITPTDQQFDESHYLPMTPK 1448
            .:..::...       :|.|...:|||.|.           ||:||              .:...
Human  1011 REATIIRHTSVRGLKRQSDERKRDRELGQCVNGDSRVELRSYVSEP--------------ELATL 1061

  Fly  1449 KVELGQPGVLTLVSATYAEEEEENHYVEMT-KGIQDEDCRSNYEIMCLASTSSSAFKVTTKTEPV 1512
            ..::.||. |.||.       .|:.|..:. :|:.....|       |..:|:.|..||.:
Human  1062 SGDMAQPS-LGLVG-------PESRYQTLPGRGLSGSTSR-------LQQSSTIAPYVTLR---- 1107

  Fly  1513 YMELAGVKASSAVPATEEAHCSSGRSTLKKCKKSGTETLKKKTKKRQGKDMPDILKPAKSALALA 1577
                .|:.|.|:            ::|..: .||..|.|.....:| ||
Human  1108 ----RGLNAESS------------KATFPR-PKSALERLYSGDHQR-GK---------------- 1138

  Fly  1578 SDSSDADDESSRQQLEAKKL---RSRSRFSLSDTFRPASYYLGASTPLNNYAESSDSEILPPPPI 1639
               ..|:::..|.:...|.|   |.|:......|..|:|.||  |.||
Human  1139 ---MSAEEQLERMKRHQKALVRERKRTLGQGERTGLPSSRYL--SRPL----------------- 1181

  Fly  1640 PASPPPMEELKTEEIFSSEHYDTV-----KRKDSNGKVNLSYEQLP----KMHASNTSLNLPKAV 1695
               |..:...|.|:.|..:..:.|     |.|:.||.  |..:.:|    .:...:..|::.:.:
Human  1182 ---PGDLGSWKREQDFDLQLLERVVQGEKKDKEENGW--LKVQAMPVTELDLEPQDYDLDISREL 1241

  Fly  1696 PSPTLKSSRLSLPDHFTKVRMTPQRLLVPATPP----------QQHHARTLSDSNYSCQLTDTSS 1750
            ..|    .::|:|:.:.:        |.|..||          :....|.:...:..|.|..||.
Human  1242 SKP----EKVSIPERYVE--------LDPEEPPSLEELQARYRKAEKIRNILARSSMCNLQPTSG 1294

  Fly  1751 R---TSSDLDLYRRRGQQQRCTSNNSLPLSSENESVEFRQRSDSELDRQRSRRPLSQESI 1807
            :   :.:||||   :.|:|....|.|..|:|| .|...:|.:..:|.....:.|||..::
Human  1295 QDQNSVADLDL---QLQEQERIINISYALASE-ASQRSKQVAAQQLALLPPKGPLSSRTV 1350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kmr	NP_001097775.2	PH_PEPP1_2_3	366..469	CDD:270068	56/121 (46%)
PLEKHA7	XP_047282382.1	WW	56..85	CDD:459800	2/11 (18%)
		PH_PEPP1_2_3	159..281	CDD:270068	56/121 (46%)
		NESP55	<299..460	CDD:115071	39/181 (22%)
		Mplasa_alph_rch	<698..>913	CDD:275316	41/264 (16%)
		CCDC90-like	779..>879	CDD:462268	23/110 (21%)