DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kmr and Plekha5

DIOPT Version :9

Sequence 1:	NP_001097775.2	Gene:	kmr / 5740131	FlyBaseID:	FBgn0085412	Length:	3090	Species:	Drosophila melanogaster
Sequence 2:	XP_006506926.1	Gene:	Plekha5 / 109135	MGIID:	1923802	Length:	1270	Species:	Mus musculus

Alignment Length:	1363	Identity:	279/1363 - (20%)
Similarity:	453/1363 - (33%)	Gaps:	451/1363 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   286 RHKNDLQTPGSEHGT-----VYIQQN-------HP----------NHVVN-QACQTQISAVKPKA 327
            |...||.|...|..|     .||..|       ||          ..||| |...|..|..|.:.
Mouse    54 RQSTDLPTGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDNCIFVVNDQTVATMTSEDKKER 118

  Fly   328 TPSSEESSSNSTKSPSHA-----PLDRKKSAGSIQ---ALKSPITKRPPSTPVTLSGWLHKQGSD 384
            ..|....:||...:..:|     |:.|...|....   ..:|...||.|:.||...|||:||.|.
Mouse   119 PISMINEASNYNMASDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDST 183

  Fly   385 GLKVWRKRWFVLAEYCLYYYKGPEEEKLLGSVLLPSYRVSACLPEDKIYRKFAFKCEHQNMRTYW 449
            |:|:|:||||||::.||:||:..:||.:|||:||||::::....||.|.||:|||..|.|||||:
Mouse   184 GMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIAMLTAEDHINRKYAFKAAHPNMRTYY 248

  Fly   450 LAADNSEAMMQWVRALAAASLMQA---------------PSSGESEPSVNSSLNH---------- 489
            ...|..:.|..|::|:..|:|:|.               .:...|....|:..||
Mouse   249 FCTDTGKEMELWMKAMLDAALVQTEPVKRITFNFRVDKITTDSASTKETNNIPNHRVLIRPEVQN 313

  Fly   490 -------------------------SGEN------SDSGIHTLQSHPGKGQPTPSSE------NT 517
                                     .|::      :...:::|.|....|...|...      |.
Mouse   314 HQKNKEISKIEEKRALEAERYGFQKDGQDRPLTKINSVKLNSLLSEYESGPDCPPQNVHYRPINV 378

  Fly   518 GSS-------------GGGSGSGQPLYANAPPKPRRINDGGYSSPSPEHNEQ---------QQQH 560
            .||             ||...:..||...|....:|.|       |.:..||         .::.
Mouse   379 NSSDGKAVNVSLADVRGGSHPNAGPLATEADRVIQRTN-------SMQQLEQWIKVQKGRGLEEE 436

  Fly   561 PSRRLMSPTQQLYQQQQHQRSQ-------------QQQQQQPQQHHAIYDTRTGHVSTALQLQQA 612
            | |.::| .|.|.:.....|:|             :..:.:|:...::  |.:||..|....::.
Mouse   437 P-RGVIS-YQTLPRNMPSHRAQILARCPEGYRTLPRNSKTRPESICSV--TSSGHEKTGPGAEEK 497

  Fly   613 QQQYSLDHLEAQFQQQQLDMEEQIARLQQQRAAEEIYGEREMYMAKLMQQRQG----PNGTYPTQ 673
            ::....|.:...::.||                      |:.|..:....|.|    |.......
Mouse   498 RRSMRDDTMWQLYEWQQ----------------------RQFYHKQSTLPRHGCLSSPKAMVQVS 540

  Fly   674 QQLLQAERRTPD-----AYGRSKQQRLFAAAAAAADYEDIYNMSQLAGGGGVPMSAQEALLQEAA 733
            .|.:.:...:|.     ||.....||.:.:...:                  |:...:..:...
Mouse   541 DQTMHSIPTSPSHGSAAAYQGFSPQRTYRSEVTS------------------PIQRGDVTIDRR- 586

  Fly   734 SYRRPLSPPSYDGSKHVPAMPQRYTPNHLEASAADQLINTMDLRARTAAAIVRPHSADFLEYEAR 798
              .||..|      |||....:|..|    |....|.::...|:.||      |.....|..:.|
Mouse   587 --HRPHHP------KHVYVADRRSMP----AGLTLQAVSPQSLQGRT------PEELTLLLIKLR 633

  Fly   799 AEAAAAAAAA--AVAQSQQESGRAPRPKSSLDINRTPDSFYYSEASYADKMRKSALYLQSGGAGA 861
            .:.|..::..  .:||..|....|..||:.:               .:..::::.:||..    .
Mouse   634 RQQAELSSVREHTLAQLMQLKLEAHSPKNEI---------------LSHHLQRNTIYLDH----Q 679

  Fly   862 AQPQQPGSYRTTGADFNSGVNTIGYENPYERAYKRQELLA-------------EAQGGGASSMP- 912
            .:..:|         ..:.|:|: .||...|....|:.|.             |.:|......|
Mouse   680 MKENEP---------IITMVHTM-IENSALRPQLYQQFLRQKNKISLYCLSQDECRGTLYKYRPE 734

  Fly   913 ------RMSRSASQGRSVASQLQSPQQEDLPPLNVHPGSIFPPSMSTQEIISKNEQFLRSASARL 971
                  ::||...|.:.|.:     .:|.|..|:....::              ||.|.|||..:
Mouse   735 EAGIDAKLSRLCEQDKVVRA-----LEEKLQQLHKEKYTL--------------EQALLSASQEI 780

  Fly   972 PKRSGG---------MDDDYSAGNSTTTSPTGGAGASNSPQHNLDGERKREESMKRLLEW----K 1023
            ...:..         ..||...|..:|......|.|        :.||...|..|  ||:    .
Mouse   781 EMNADNPAAIQTVVLQRDDLQNGLLSTCRELSRATA--------ELERAWREYDK--LEYDVTVT 835

  Fly  1024 QRMLQSPLTRKGIQQGGSN-----------------MSAMSK----LGSNPNILLASTAVASGAR 1067
            :..:|..|.|.|..|..|.                 |..:||    .||:..:.||.:...|..:
Mouse   836 RDQMQGQLDRLGEVQSESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGSSETVGLAGSKPFSSVK 900

  Fly  1068 YAPQAGKTV-----LVGNGNGTAQGAGNPP----SASGIQRSRS-----------------ESQA 1106
            |..:..:.|     |..:.:.|.|....||    |:|.:..||.                 .:.:
Mouse   901 YKSEEEEVVPPRPPLPRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEDKKIHQVQGYPRNGS 965

  Fly  1107 NVGPGGVVYNNYSSDDEAGTVDDDNLYSATAGRSSSSKTTTKATTSQAIVATTTAALAITNLGSS 1171
            :.||.   |..|.|:.|..||       |....|:..:.:...:.::|.|..          ||.
Mouse   966 HCGPD---YRLYKSEPELTTV-------AEVDESNGEEKSEPVSETEAPVVK----------GSH 1010

  Fly  1172 KNLETPNQTETEATPSSSSTAS-----STKAKFQL------------------KPILKVHEASKT 1213
            ..:..|.:|:: .||.||:.||     .||...:|                  :|.:.|.|..:
Mouse  1011 FPVGVPLRTKS-PTPESSTIASYVTLRKTKKMVELRTERPRSAVEQLCLAESARPRMTVEEQLE- 1073

  Fly  1214 RIIQVQPKHLEERPK------------LR---LQLPKAMGNEEEQKQEDEEQENVEAEPVPILPK 1263
            ||.:.|...|.|:.|            :|   |:|.:.:..::..|:.|......:.:|....|.
Mouse  1074 RIRRHQQACLREKKKGLSVLGASDPSDVRDSPLRLTQTLRRDDNVKELDTVHRENDVKPDYETPA 1138

  Fly  1264 KTA----PKSPQNANYVPVYNNKLVSNYENMEFGKPIPESKIPHSNAAITDPEETPMLMQLKLFK 1324
            ...    ...||||                 :.|:.:..|::.::      ||...|.      .
Mouse  1139 AQCAHLEDAEPQNA-----------------DIGRKLKRSEMLYT------PEPNGMA------S 1174

  Fly  1325 EQQDQQKQQQENEEEDLTPTAESKPIPGEEDMGAPKVIKDQKLESNEEEQELEDEDDSTA-CE 1386
            |:..::::|:|....|.:.:.:.:....|..|..|.          ||.:.|.:|:::.| ||
Mouse  1175 EEVTEKERQKEQVHADGSCSPQEETAMTEHQMEGPP----------EEAESLHEEEETLASCE 1227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmr	NP_001097775.2	PH_PEPP1_2_3	366..469	CDD:270068	50/102 (49%)
kmr	NP_001097775.2	PH	372..469	CDD:278594	47/96 (49%)
Plekha5	XP_006506926.1	WW	13..42	CDD:366073
		WW	59..88	CDD:366073	7/28 (25%)
		PH_PEPP1_2_3	165..268	CDD:270068	50/102 (49%)
		Smc	<623..>864	CDD:224117	53/298 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	115	1.000	Domainoid score	I6000
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43685
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12752
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2051
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.040