DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kmr and plekha4

DIOPT Version :9

Sequence 1:	NP_001097775.2	Gene:	kmr / 5740131	FlyBaseID:	FBgn0085412	Length:	3090	Species:	Drosophila melanogaster
Sequence 2:	XP_012821617.2	Gene:	plekha4 / 100170544	XenbaseID:	XB-GENE-986079	Length:	1470	Species:	Xenopus tropicalis

Alignment Length:	1656	Identity:	320/1656 - (19%)
Similarity:	541/1656 - (32%)	Gaps:	520/1656 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   320 ISAVKPKATPSSEESSSNSTKSPSHAPLDRKKSAGSIQALKSPITKRPPSTPVTLSGWLHKQGSD 384
            :|.....||.:|....|.    ||...:.|..:.|.    :....||.|::||.:.|||:||.|.
Frog    12 LSVASSVATNASVSQGSR----PSTRSVKRVHTFGK----REYSIKRDPNSPVVIRGWLYKQDSS 68

  Fly   385 GLKVWRKRWFVLAEYCLYYYKGPEEEKLLGSVLLPSYRVSACLPEDKIYRKFAFKCEHQNMRTYW 449
            ||::|::|||||:::||:||:...||.:|||:|||||::....|.:...|:|:||.||..||||:
Frog    69 GLRLWKRRWFVLSDFCLFYYRDSREEIVLGSILLPSYQILPANPREVKNRRFSFKAEHPGMRTYY 133

  Fly   450 LAADNSEAMMQWVRALAAASLMQAPSSGESEPSVNSS-------------LNHSGENSDSGIH-- 499
            ..||..|.|..|:||:..:||:.:....::....|.|             |:||| .|.:|.|
Frog   134 FGADTHEDMNSWIRAMNQSSLVVSEDRNKNSQVQNLSNSTQEDLYASYEDLSHSG-ISAAGEHAK 197

  Fly   500 ------------TLQSHPGKGQPTPSSENTGSSGGG---SGSGQPLYANAPPKPRRINDGGYSSP 549
                        |........:..|..|..|.....   ||..:.|............:|....|
Frog   198 SAESLEIAHLSETRSQDESSRESLPEQERNGDFDKDSLFSGLKESLSDAIQHFTTLSQNGSVPPP 262

  Fly   550 SPEHNEQQQQHPSRRLMSPTQQLYQQQQHQRSQQQQQQQPQQH---------------------- 592
            :||:..:....|..||         :.::|||.:::...|:..
Frog   263 TPENGVKGTDFPYSRL---------ELENQRSLERKDSIPEDEEWVPFHKDELSIKEPLESYSSR 318

  Fly   593 -------------HAIYD---TRTGHVSTA-----LQLQQAQQQYSLDHLEAQFQQQQLDMEEQI 636
                         |.:|.   :|:...|.|     :.:.:|.::.:.|   .::..|....|...
Frog   319 SPPRVPPKGFECPHDVYSSPLSRSAPSSPAVLPGHMYISEAGERNARD---GKYVTQSEPPESPQ 380

  Fly   637 ARLQQ-----------------------QRAAE------------EI---------------YG- 650
            .|||.                       ||..:            |:               ||
Frog   381 IRLQSPISSCSPPRVTTCPSPEIREFVIQRLVKPSRSFSLPPTPSELPRHRMSKMSPPPSVKYGG 445

  Fly   651 ----EREMYMAKLMQQRQGPNGTYPTQQQLLQAERRTPDAYGRSKQQRLFAAAAAAADYEDIYNM 711
                |:.|..:.......||....||::.:|....|:|.:...|.|         ||..||:
Frog   446 PFICEKSMQYSDTSHASPGPPVGSPTRKDILYNAGRSPKSQPNSSQ---------AASNEDL--- 498

  Fly   712 SQLAGGGGVPMSAQEALLQEAASYRRPLSPPSYDGSKHVPAMPQR----YTPNHLEASAADQLIN 772
                     .:||..:|.:.......|:.....     |||..:.    ::|.|:|..|.:..:.
Frog   499 ---------AVSASPSLGRTTVRSNTPIGRVDM-----VPAEDKAGNFIHSPRHIEDRAGEYFVT 549

  Fly   773 TMDLRARTAAAIVRPHSA----DFLEYEARAEAAAAAAAAAVAQSQQESGRAPRPKSSLDINRTP 833
            :...|.....::.||.:.    |.|..|.|      .:::.:|:......|..:|..:.| .|..
Frog   550 SSRTRGHMMKSLSRPQTPSDRYDVLPTEER------YSSSTIAKGPNRYSRRTQPLGAED-ERLV 607

  Fly   834 DSFYYSEASYADKMRKSALYLQSGGAGAAQPQQPGSYRTTGADFNSGV---NTIGYENPYE---- 891
            |                       |.|...||:..:|..:........   ..|..|.|.|
Frog   608 D-----------------------GCGMPIPQRTHAYPNSRMQMRPSTPAERVIVEECPSELSLT 649

  Fly   892 -----------RAYKRQELLAEA--QGGGASSMPRMSRSASQGRSVASQLQSPQQEDLPPLNVHP 943
                       |.|..:.||.:.  .|....|.||..:  ..|.|..|||     ..|||:...|
Frog   650 PSLRRHGSQVTRQYSERPLLPQGTFSGRAVGSAPRQLQ--KMGSSSYSQL-----PPLPPVAGRP 707

  Fly   944 GSIFP----------PSMST--------QEIISKNE---------------QFLRSASARLPKRS 975
            |...|          ||.|.        |..:::|.               ..|...:|.|....
Frog   708 GPHVPAGKRMSLSAMPSGSAPYRERVPYQVRLAENNIDVLLTKLCGQDKLLVSLEDETAHLRAEK 772

  Fly   976 GGMDDDYSAGNSTTTSPTGGAGASNSPQHNLDGERKREESMKRLLEWKQRMLQSPLTR------- 1033
            ..::|                 |..:..|:|: |.:.::.:...:.::||:||..|..
Frog   773 EKLED-----------------ALQATHHHLE-EFQGQDHVIENIWYQQRLLQDDLVYVRARLCD 819

  Fly  1034 ----------------------------------------------------KGIQQGGSNMSAM 1046
                                                                .|::...|.:..:
Frog   820 LTLERERAWEEYRGLDNELLTVRETLDRVGQIGHPQDQLAAQRDLWMINDIISGLRFNKSTIHVL 884

  Fly  1047 SKLGSNPNILLASTAVASGARYAPQAGKTVLVGNGNGTAQGAGNPPSASGIQRSRSESQANVGPG 1111
            .:...:|.:::||:.|   :...|...::.|        ..:|..|:|....:..||:.....|.
Frog   885 PESSRHPGMMIASSPV---SETQPAYQRSFL--------HHSGLHPAAPRDAQKDSEAVPPRPPL 938

  Fly  1112 GVVYNNYSSDD----EAGTVDDDNLYSATAGRSSSSKTTTKATTSQAIVATTTAALAI-TNLGSS 1171
            ...:::.:|.|    ..|...:.|.......|.:.|..:.||....   |:|...:|| .::||.
Frog   939 PRDHHSAASTDMDGKNRGGSTEQNEQELPMERLTDSAPSAKAGQQP---ASTPGDVAIRRDVGSD 1000

  Fly  1172 KNLETPNQTETEATPSSSSTASSTKAKFQLKPILKVHEASKTRIIQVQPKHLEERPKLRLQLPKA 1236
            ..   |..:...|.|:.....|..|                     |.|..|.|...:|.|   .
Frog  1001 PK---PQSSCPVAIPTGPKVISEAK---------------------VSPPCLAEVGTVRKQ---R 1038

  Fly  1237 MGNEEEQKQEDEEQE-NVEAEPVPILPKKTAPKSPQNANYVPVYNNKLVSNYENMEFGKPIPESK 1300
            |..||:.::....|| .:...|.|.:  .|..::.|..| .||.:....::...:..|...|...
Frog  1039 MSAEEQMERMRRHQEAQIHERPKPGV--TTQRQNSQRGN-TPVISRLRSASSGTISSGTISPGPN 1100

  Fly  1301 IPHSNAAITDPEE-TPMLMQLKLFKEQQDQQKQQQENEEEDLTPTAESKPIPGEEDMGAPKVIKD 1364
            .|..::|.  ||: .|.|:::                 .....|:..|.|.||:.....||...:
Frog  1101 SPQVDSAC--PEQRRPALVKV-----------------TASFYPSTTSTPQPGKGGSIKPKAASN 1146

  Fly  1365 QKLESNEEEQELEDEDDSTACEEYTDDDIDEALAQDDEDEAVVEAV--ESQELAEERELQQIYVN 1427
             |::.|:            |...||.||...:|..:.:.|::|...  |...:|:        :.
Frog  1147 -KVQENQ------------AVGYYTTDDPTYSLVMEPQSESIVSTTCHEISPMAK--------MT 1190

  Fly  1428 EPITPTDQ----QFDESHYLPMTPKKVELGQPGVLTLVSATYAEEEEENHYVEM----TKGIQDE 1484
            .|:..:.:    ...::.:.|...|:..|.|        ||.:.|.:.:...|:    .|.::
Frog  1191 PPLRTSSKIVTAACKQAKWEPQGDKEQRLNQ--------ATPSPERKPDSVPELLEVKKKAVE-- 1245

  Fly  1485 DCRSNYEIMCLASTSSSAFKVTTKTEPVYMELAGVKASSAVPATEEAHCSSGRSTLKKCKKSGTE 1549
                            .|...||||.|                          :|...|.:...:
Frog  1246 ----------------RAKTATTKTSP--------------------------ATSPGCSRHSDD 1268

  Fly  1550 TLKKKTKKRQGKDMPDILKPAKSALALASDSSDADDESSRQQLEAKKLRSRSRFSLSDTFRPASY 1614
            ..|.....::.:.:       ..:..|||::|:.....:.:.| |.::.:.|..|.||...|..:
Frog  1269 DYKMANSGQRERII-------SLSYTLASEASELSKMMTAKTL-ADEMDANSDVSTSDEAYPWDF 1325

  Fly  1615 YLGASTPLNNYAESSDSEILPPPPIPASPPPMEELKTEEIFSSEHYDTVKRKDSNGKVN--LSYE 1677
            .:..|.. :.:.|:|:...|..||   ..|..|:.......:.:.|.:..:..|.|..:  |.:.
Frog  1326 IMQDSRS-SKHPETSERCQLKGPP---DAPQGEDRNANVAENCQTYCSTNQCSSGGPCSPQLQHR 1386

  Fly  1678 QLPKMHASNTSLNLPKAVPSPTLKSSRLSLP 1708
            ..||.|..|...   :..|:|..|.|..:.|
Frog  1387 DSPKGHTDNQHY---ENWPAPREKGSTDNCP 1414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmr	NP_001097775.2	PH_PEPP1_2_3	366..469	CDD:270068	50/102 (49%)
kmr	NP_001097775.2	PH	372..469	CDD:278594	47/96 (49%)
plekha4	XP_012821617.2	PH_PEPP1_2_3	50..153	CDD:270068	50/102 (49%)
plekha4	XP_012821617.2	EzrA	<738..>848	CDD:226883	14/127 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	114	1.000	Domainoid score	I6001
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003396
OrthoInspector	1	1.000	-	-		otm48858
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910