DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kmr and dock9b

DIOPT Version :9

Sequence 1:	NP_001097775.2	Gene:	kmr / 5740131	FlyBaseID:	FBgn0085412	Length:	3090	Species:	Drosophila melanogaster
Sequence 2:	XP_021332715.1	Gene:	dock9b / 100151488	ZFINID:	ZDB-GENE-090916-2	Length:	2095	Species:	Danio rerio

Alignment Length:	2527	Identity:	456/2527 - (18%)
Similarity:	740/2527 - (29%)	Gaps:	1009/2527 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   701 AAADYEDIYNMSQLAGGGGVPMSAQEALLQEAASYRRPLSPPSYDGSKHVPAMPQRYTP------ 759
            ||...||...:|:.......|::|..|:..:.      :.|..|:.     .:.||.|.
Zfish    31 AAEPDEDEDTLSRRESLAVTPLAAASAVKPKV------IEPLDYEN-----VLVQRKTQILSDVL 84

  Fly   760 -NHLEASAADQLINTMDLRARTAAAIVRPHSADFLEYEARAEAAAAAAAAAVAQS---------- 813
             :.|:....|..|:|:..:.||..:.| |..|     |.||.:...........|
Zfish    85 RDMLQFPIDDFQISTLKRQGRTLYSSV-PDGA-----EKRASSLLVQECIKTYNSDWHVVNYKYE 143

  Fly   814 ------QQESGRAPRPKSSLDINRTPDSFYYSEASYADKMRKSA-LYLQSGGAGAAQPQQPGSYR 871
                  :|...:.|||:...       |..:.....|||...:| |..|.||..    :....|:
Zfish   144 DYSGDFRQLPNKVPRPEKLA-------SHVFEVDEDADKEEDAASLGSQRGGVS----KHGWLYK 197

  Fly   872 TTGADFNSGVNTI--GYENPYERA------------YKRQELLAEAQGG-------GASSMPRMS 915
               |:.||.::..  .::..|...            ||.:::..|.:|.       |.....::.
Zfish   198 ---ANMNSAISVTMKSFKRRYFHLTQLGDGSYNLNFYKDEKISKEPKGTIFLDSCMGVIQNSKVR 259

  Fly   916 RSA----SQGRS---VASQLQSPQQEDLPPLNVHPGSIFPPSMSTQEIISKNEQFLRSASARLPK 973
            |.|    .|.:|   :|:..:....:.:..||....|.|  .::.||                 :
Zfish   260 RFAFELKMQDKSTYLLAADSEGEMDDWISTLNKILHSSF--ELAMQE-----------------R 305

  Fly   974 RSGGMDDDYSAGNSTTTSPTGGAGASNSPQHNLDGERK-REESMKRLLEWKQRMLQSPLTRKGIQ 1037
            |:|.:.||...| .|..||   ....:|.|...|.|.| |.|:..:|      ....|.|::
Zfish   306 RNGELHDDDEMG-KTDISP---GNFQDSFQSARDIESKMRSETRLKL------FTLDPDTQR--- 357

  Fly  1038 QGGSNMSAMSKLGSNPNILLASTAVASGARYAPQAGKTVLV-------GNGNGTAQGAGNPP--- 1092
                    :...|..|::          .::..:.||.|||       ...:..|:....|.
Zfish   358 --------LDLSGIEPDV----------KQFEEKFGKRVLVCCNDLSFNLQSCVAENEEGPTTNV 404

  Fly  1093 -------SASGIQRSRSES---------------------QANVGPGGVVYNNYSSDDEAGTVDD 1129
                   |...:|.||..|                     |.|   |||           .|...
Zfish   405 EPFFVVLSLFDVQNSRKISADFHVDLNHPLVRSLIPSPSMQIN---GGV-----------DTPHG 455

  Fly  1130 DNLYSATAGRSSSSKTTTKATTSQ----AIVATTTAAL--AITNLGSSKNLETPNQTETEATPSS 1188
            :.|.|...|.....|....:.|..    .:||.....|  .||:........:.:....:....:
Zfish   456 ETLLSELQGMLHYPKKGVFSVTCPHPDIFLVARIEKVLQGGITHCAEPYMKSSDSSKVAQKVLKN 520

  Fly  1189 SSTASSTKAKFQL------KPILKVHEASKT--------RIIQVQPKHLEE-----------RPK 1228
            :..|.|...::::      :|:.|  :||.|        .:.:.....|.|           :|:
Zfish   521 AKMACSRLGQYRMPFAWAARPVFK--DASGTLDKSARFSALYRQDSNKLSEEDLFKLLADFRKPE 583

  Fly  1229 LRLQLPKAMGNEEEQKQEDEEQENVEAEPVPILPKKTAPKSPQNAN-----YVPVYNNKLVSNYE 1288
            ...:||..:||.:           |..:.||          |..||     |:||
Zfish   584 KMAKLPVILGNLD-----------VTIDNVP----------PDMANCVTPSYIPV---------- 617

  Fly  1289 NMEFGKPIPESKIPHSNAAITDPEETPMLMQ-----------LKLFKE--QQDQQK--------- 1331
                 :|. ||..|:....:...|..|.:.:           |.::.:  :.|.||
Zfish   618 -----RPF-ESNGPNDGVLLEVEEFVPCIAKCSQPFTTYNNHLYVYPKHLKYDNQKSFAKARNIA 676

  Fly  1332 ---QQQENEEEDLTPTAES-KPIPGEEDMGAPKVIKD--QKLESNEEEQELEDE----------- 1379
               :.:|::|||    |:: |.|.|..  |.|...|.  ..:..:::..|..||
Zfish   677 VCVEFRESDEED----AQALKCIYGRP--GGPVFTKHAYAAVLHHQQNPEFYDEIKIELPTQLHE 735

  Fly  1380 -------------DDSTACEEYTDDDIDEALAQDDEDEAVVEAVESQELAEERELQQIYVNEPIT 1431
                         |.||...:..:..:..|.....:|..||  :..|.::....|...|:
Zfish   736 KHHLLFTFYHISCDSSTKKRDIVETPVGSAWLPLLKDGRVV--MSEQHISVASNLPNGYL----- 793

  Fly  1432 PTDQQFDESHYLPMTPKKVELGQP--GVLT-LVSATYAEEEE----ENHYVEMTKG----IQDED 1485
             :.|:....|..|.. |.|:.|:|  .|.| |||..|.:::.    .:|:..|..|    .:.|.
Zfish   794 -SCQEGVSKHSSPEI-KWVDGGRPLFRVSTHLVSTIYTQDQHLHNFFHHFHSMQSGAPRPTEGEL 856

  Fly  1486 CRSNYEIMCLASTSSSAFKVTTKTEPVYMELAGVKASSAVPATE-----EAHCSSG------RST 1539
            .:....:..:.......|..|...:.:::..:......||..|.     .|.|...      ||.
Zfish   857 VKYLKSLHAMEGHVMINFLPTILNQMIHVLTSATNEDVAVNTTRVMVHIVAQCHEEGLEHYLRSY 921

  Fly  1540 LKKCKKSGTETL----KKKTKKRQGKDMPDILKPAKSAL--------------ALASDSSDADDE 1586
            :|...|  ||:.    .|...:...|.|..||||:...|              ||....:....|
Zfish   922 VKYVFK--TESYSNGNSKTVHEELAKAMTSILKPSTDFLTSNKLLKYSWYFFEALVKSMAQYLME 984

  Fly  1587 SSRQQLEAKKLRSRSRFSLS------------------------DTFRPASYYLG---------- 1617
            |.:     .||....||:.|                        |..|.|::.|.
Zfish   985 SGK-----VKLSRNQRFTASFHHAVETLVNMLMPHITQKYKDNLDAARNANHSLAVFIKRCFTFM 1044

  Fly  1618 ----ASTPLNNYAESSDSEILPPPPIPASPPPMEELKTEEI---FSSEHYDTVKRKDSNGKVNLS 1675
                ....:|||....         :|..|..:.|.|.|.:   .:.|||
Zfish  1045 DRGFVFKQINNYITCF---------VPGDPKTLYEFKFEFLRVACNHEHY--------------- 1085

  Fly  1676 YEQLPKMHASNTSLNLPKAVPSPTLKSSRLSLPDHFTKVRMTPQRLLVPATPPQQHHARTLSDSN 1740
                               ||        |:||..|.|.|:  ||               ..|..
Zfish  1086 -------------------VP--------LNLPMPFGKGRI--QR---------------FQDLQ 1106

  Fly  1741 YSCQLTDTSSRTSSDLDLYRRR--GQQQRCTSNNSLPLSSENESVEFRQRSDSELDRQRSRRPLS 1803
            ....|||...|....:.|..|.  |..|                 ||.:              :.
Zfish  1107 LDYSLTDDFCRNHFLVGLLLREVCGALQ-----------------EFGE--------------VR 1140

  Fly  1804 QESISEIESL--SEQFEETLSSHELDTYLSHLHLSTGQATPTSHLLNDANAAAGADILTNLIKPP 1866
            |.:|..::||  ...|::...|......|:.|:|      |...||.:
Zfish  1141 QIAIQVLKSLMIKHTFDDRYVSKSQQARLATLYL------PLFGLLQE----------------- 1182

  Fly  1867 KTFRNAEDEEQHFYGNIHFLSSTDSIQQLGEAGATALRIIHSRNNSNISTQSAPYYYSELPAPPP 1931
                           |:|.|:..|:                    ||.:|.
Zfish  1183 ---------------NVHRLNVRDA--------------------SNFNTN-------------- 1198

  Fly  1932 LNNQRDIHAHGLNIAHIHNPIDRHQFNVDALVDKDQAIDSKNIYCGQKDNNEKLSNKNLKLNKSV 1996
             .|.||.|...:..|....|:                        |..||:         |:|.|
Zfish  1199 -QNGRDEHLASIPSATPQKPV------------------------GNLDNS---------LHKDV 1229

  Fly  1997 DLPAEMEGSGSSGGALNPVVHSYLTTTKNTNLAR--KTIGGSNPSDDGNPNEDGAGENTEEAGKT 2059
                    .|...|..:|  |   |:|.|....|  .:.|....:|.||...|...|.|....||
Zfish  1230 --------FGVISGTASP--H---TSTPNIGSVRHADSRGSLISTDSGNSLPDKTNEKTGSLEKT 1281

  Fly  2060 PSNNVHTNLSVLGGELL-----------------------WEEDAL---WRES------------ 2086
            .|      .|.||..:|                       ..||||   |.::
Zfish  1282 QS------ASALGSSMLRCDKLDREEIKNLLMCFLHVLKSMSEDALFTYWNKATTSELMDFFTLV 1340

  Fly  2087 ------LRRVSQRH-ARSLDDL-----DRITAAPPISSTPKAKLSREVTYVNDSLKPRQHPHITN 2139
                  .|.:.:|. |||.|.:     ||.:...|:|....:.:...:    ..|...::.|..|
Zfish  1341 EVCLHQFRYMGKRFIARSQDGVGFMVPDRKSLTLPVSRNRGSVMHTRL----HQLGSLENSHTFN 1401

  Fly  2140 E---H--------------DVYVQLMDTTS-----------SSHDHDQTDSDVYEV-------LR 2169
            .   |              :|.:.::||.|           :...|:.....|::|       .:
Zfish  1402 HTYCHADADACLLEANISTEVCLTVLDTLSVFIMGFKTQLCADLGHNPLMKKVFQVHLCFLQIPQ 1466

  Fly  2170 EETA---------------------------------------SNLSHKSNELDRETIRQWDA-- 2193
            .|||                                       |.||         :||. ||
Zfish  1467 SETALKQVFTSLRTFIYKFPCTFFDGRADMCACLCYEILKCCNSKLS---------SIRS-DAAH 1521

  Fly  2194 MSSGLMKSNHSGVEATGASS---AHLPLTSSVRSIVQQLNNSSMDDANGNPMATASISVRNVNNL 2255
            :...|||||   .|..|..|   .||.:..:|..::..:...      |......|:|:  :||.
Zfish  1522 LLYFLMKSN---FEYNGRKSFVRTHLQVVIAVSQLIADVIGI------GGTRFQQSLSI--INNC 1575

  Fly  2256 PVGNLTVKPD--PSDV-------------------HQES---------AFAPYYGGAAETK---- 2286
            ...:.|||..  ||||                   |::.         :.|..|....|.:
Zfish  1576 ANSDKTVKHTAFPSDVKDLTKRIRTVLMATEQMKEHEKDPEMLVDLQYSLAKSYTSTPELRKTWL 1640

  Fly  2287 ------YAKNTVLTD------------------RGLYAANGSGLATSTPQNHQQFRMR------- 2320
                  :.||..|::                  :|::..........||...::..|.
Zfish  1641 DSMAKIHVKNGDLSEAAMCYVHVAALVAEYLKRKGMFRQGCCAFRVITPNIDEEAAMMEDVGMQD 1705

  Fly  2321 -HTGSRAEIDMLERETSSQIRNRLRSAEGLTRAESI---------------QRLDYLK-QHLLD- 2367
             |......:::||           ..|:||.:||..               ||.|:.| .||.|
Zfish  1706 VHFNEEVLMELLE-----------ACADGLWKAERYELISDIYKLIIPIYEQRRDFEKLAHLYDT 1759

  Fly  2368 LERHYEKSKPLVNLVDNMVKLGSLYR-----------NDANGR----VQPATLDRLEFNQRM--- 2414
            |.|.|.|...:::....:  ||:.:|           .|.:|:    .:|......|.:||:
Zfish  1760 LHRAYTKVMEVMHSGKRL--LGTFFRVAFFGQAAGFFEDEDGKEYIYKEPKFTPLSEISQRLLKL 1822

  Fly  2415 ------QEQ-QMLQEEQQQWERLSPN--QAELQVRELYQLDQLLQEESGTLQSLQRDKEDLERAL 2470
                  ||. :|:|:.    .|::|.  :|:....::..:...|:|     :.|:..|.|.||:
Zfish  1823 YSDKFGQENVKMIQDS----GRVNPKDLEAKFAYIQVTHVTPYLEE-----KELEERKTDFERS- 1877

  Fly  2471 GGLRARIHDSNATPMALEAAKKQQHILER----------------------------ELSRVHQL 2507
            ..:|..:.:   ||.. |:.|:...:.|:                            :||.:...
Zfish  1878 HNIRRFVFE---TPFT-ESGKRHGGVEEQCKRRTVLTTTHCFPYVKKRIAVMYQHHTDLSPIEVA 1938

  Fly  2508 LAENSKKLEQTVAGNARLEQELLLLRQKVQAVRGSTTNGMNGDGSHINGDQTAAVLASELERVQS 2572
            :.|.|.|:.:..|..|..|.:::.|:.|:|                  |..:..|.|..|...::
Zfish  1939 IDEMSGKVAELRALCATSEVDMIRLQLKLQ------------------GSISVQVNAGPLAYARA 1985

  Fly  2573 LVGDMQRQRHELSSAVRQLTENSTRLYQEIGNKEMNGGGSTNGSLKKRSNSTSWTETDLDANMLR 2637
            .:.|...:::. .:.|:||.|...:..:..|.     ..:.|..|.|........|
Zfish  1986 FLDDACAKKYP-DNKVKQLKEVFRQFVEACGQ-----ALAVNERLIKEDQQEYHDE--------- 2035

  Fly  2638 CGSRQQLNDSTLNLSTPLY-----VDTNSSTKLSD----YNRYNGSSDAIEMSGVDS 2685
              .:....|....||..::     ||..:.:.|||    :|..:|:..:..:.|:.|
Zfish  2036 --MKASYRDLARELSNIMHEQISAVDGGTKSALSDSLHIFNAISGTPTSTTLHGMPS 2090

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmr	NP_001097775.2	PH_PEPP1_2_3	366..469	CDD:270068
kmr	NP_001097775.2	PH	372..469	CDD:278594
dock9b	XP_021332715.1	DUF3398	77..168	CDD:314708	19/103 (18%)
		PH_DOCK-D	184..307	CDD:270087	24/148 (16%)
		C2_Dock-D	650..832	CDD:176079	41/196 (21%)
		DHR2_DOCK9	1634..2050	CDD:212571	84/477 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910