Protein Alignment Pp1-Y1 and PPP3CA

DIOPT Version :10

• Sequence 1: NP_001104152.3
• Gene: Pp1-Y1 / 5740113
• FlyBaseID: FBgn0261399
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_000935.1
• Gene: PPP3CA / 5530
• HGNCID: 9314
• Length: 521
• Species: Homo sapiens
• Alignment Length: 265
• Identity: 108/265 - (40%)
• Similarity: 158/265 - (59%)
• Gaps: 13/265 - (4%)

  Fly    37 ESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDR 101
            ||..::::.:...:|..|..||.::|||.|.||||||:.||::.||..|.|...|||.|||||||
Human    58 ESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDR 122

  Fly   102 GKYSVETLTLLLAYKVRYPTSIHLLRGNHESAAINRYYGFYDECKRRFTIRLWRMFVDCYDCLPV 166
            |.:|:|.:..|.|.|:.||.::.|||||||...:..|:.|..|||.:::.|::...:|.:||||:
Human   123 GYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPL 187

  Fly   167 AAIINSKIFCCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDLLWSDP------DPTAIGWEKNS 225
            ||::|.:..|.||||||.::.|:||:.|.|..|....|.:||:|||||      :.|...:..|:
Human   188 AALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNT 252

  Fly   226 -RGVSFTFGVDIVETFLSRFSFDLICRAHQVVEDGYEFFAKRQ------LITVFSAVNYCGEFDN 283
             ||.|:.:....|..||...:...|.|||:..:.||..:.|.|      |||:|||.||...::|
Human   253 VRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNN 317

  Fly   284 AGAMM 288
            ..|::
Human   318 KAAVL 322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pp1-Y1	NP_001104152.3	MPP_superfamily	17..303	CDD:472684	108/265 (41%)
PPP3CA	NP_000935.1	MPP_PP2B	41..345	CDD:277361	108/265 (41%)
		Catalytic. /evidence=ECO:0000305	56..340		108/265 (41%)
		SAPNY motif. /evidence=ECO:0000305|PubMed:26248042	307..311		2/3 (67%)
		Interaction with PxIxIF motif in substrate. /evidence=ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:17502104, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26248042	327..336
		Calcineurin B binding. /evidence=ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402	341..369
		Calmodulin-binding. /evidence=ECO:0000269|PubMed:18384083, ECO:0000269|PubMed:19404396, ECO:0000269|PubMed:25144868, ECO:0000269|Ref.34	392..406
		Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298	407..414
		Autoinhibitory domain. /evidence=ECO:0000269|PubMed:8524402	465..487
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	475..521