Protein Alignment CLK4 and Doa

DIOPT Version :10

• Sequence 1: NP_065717.1
• Gene: CLK4 / 57396
• HGNCID: 13659
• Length: 481
• Species: Homo sapiens
• Sequence 2: NP_001014681.2
• Gene: Doa / 43415
• FlyBaseID: FBgn0265998
• Length: 2045
• Species: Drosophila melanogaster
• Alignment Length: 539
• Identity: 239/539 - (44%)
• Similarity: 329/539 - (61%)
• Gaps: 73/539 - (13%)

Human     7 THCPDWDSRE-----SWGHESYRGSHKRKRRSHSSTQENRHC--------------------KPH 46
            ||...:.|.:     .:..:..:..|.::::.|...|:::|.                    ||.
  Fly  1483 THSASFSSAQRPTALQFHQQHQQQQHLQQQQQHPQQQQHQHSSFGVGMMSRNYYNMPKQPERKPL 1547

Human    47 HQFKESDCHYLEARSLNERDYRDRRY--VDEYRNDYCEG---------YVPRHYHRDIESGYRIH 100
            ..|  ....|.:...:....|:.::.  ..:::|....|         |.|   :.:.:..|...
  Fly  1548 QTF--DPYAYPKPNQMQPVKYQQQQQHPHTQFQNASAGGGGGGAAGLQYDP---NTNTQLFYASP 1607

Human   101 CSKSSVRSRRSSPKRKRNRHCSSHQSRS----------KSHRRKR---SRS-------------I 139
            .|.||.:..:...::::.:.....||.|          :.|::::   |:|             |
  Fly  1608 ASSSSNKQPQQPQQQQQQQQSQLQQSNSVIFNHSGQQHQPHQQQQNEMSKSALGLHFIETAKPVI 1672

Human   140 EDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSE 204
            :||.:||||..:||:|..||:|:.|||||.||:||:..|...| ..:|:||:|||.:|||||:.|
  Fly  1673 QDDADGHLIYHTGDILHHRYKIMATLGEGTFGRVVKVKDMERD-YCMALKIIKNVEKYREAAKLE 1736

Human   205 IQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQ 269
            |..||.:...||:....||:|::|||:|||:|||||:||||.:||::||::.|:.:|.:|.||||
  Fly  1737 INALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVFDFLRENNYEPYPLDQVRHMAYQ 1801

Human   270 ICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHH 334
            :|.|:.|||.|:||||||||||||||.|||...||.|:.|:.|.:||||::::||||||:|.|||
  Fly  1802 LCYSVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLIDFGSATFDHEHH 1866

Human   335 STLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIP-- 397
            ||:|||||||||||||.||||||||||||||||.|.|||.|:|||||::|||||||||||.||
  Fly  1867 STIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQTHDNREHLAMMERILGQIPYR 1931

Human   398 ---QHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYD 459
               .|.:....|.|||:|.:|||||.||||||||..||||....|...|:|.:||.|:::||||:
  Fly  1932 MARNHTLYSKTKTKYFYHGKLDWDEKSSAGRYVRDHCKPLFLCQLSDSEDHCELFSLIKKMLEYE 1996

Human   460 PTQRITLDEALQHPFFDLL 478
            |:.||||.|||.|||||.|
  Fly  1997 PSSRITLGEALHHPFFDRL 2015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLK4	NP_065717.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..46		8/63 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	102..143		11/66 (17%)
		PKc_CLK1_4	146..475	CDD:271115	205/333 (62%)
Doa	NP_001014681.2	PHA03247	<205..634	CDD:223021
		PKc_CLK	1679..2012	CDD:271036	205/333 (62%)