DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CLK4 and Doa

DIOPT Version :9

Sequence 1:	NP_065717.1	Gene:	CLK4 / 57396	HGNCID:	13659	Length:	481	Species:	Homo sapiens
Sequence 2:	NP_001014681.2	Gene:	Doa / 43415	FlyBaseID:	FBgn0265998	Length:	2045	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	239/539 - (44%)
Similarity:	329/539 - (61%)	Gaps:	73/539 - (13%)

- Green bases have known domain annotations that are detailed below.

Human     7 THCPDWDSRE-----SWGHESYRGSHKRKRRSHSSTQENRHC--------------------KPH 46
            ||...:.|.:     .:..:..:..|.::::.|...|:::|.                    ||.
  Fly  1483 THSASFSSAQRPTALQFHQQHQQQQHLQQQQQHPQQQQHQHSSFGVGMMSRNYYNMPKQPERKPL 1547

Human    47 HQFKESDCHYLEARSLNERDYRDRRY--VDEYRNDYCEG---------YVPRHYHRDIESGYRIH 100
            ..|  ....|.:...:....|:.::.  ..:::|....|         |.|   :.:.:..|...
  Fly  1548 QTF--DPYAYPKPNQMQPVKYQQQQQHPHTQFQNASAGGGGGGAAGLQYDP---NTNTQLFYASP 1607

Human   101 CSKSSVRSRRSSPKRKRNRHCSSHQSRS----------KSHRRKR---SRS-------------I 139
            .|.||.:..:...::::.:.....||.|          :.|::::   |:|             |
  Fly  1608 ASSSSNKQPQQPQQQQQQQQSQLQQSNSVIFNHSGQQHQPHQQQQNEMSKSALGLHFIETAKPVI 1672

Human   140 EDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSE 204
            :||.:||||..:||:|..||:|:.|||||.||:||:..|...| ..:|:||:|||.:|||||:.|
  Fly  1673 QDDADGHLIYHTGDILHHRYKIMATLGEGTFGRVVKVKDMERD-YCMALKIIKNVEKYREAAKLE 1736

Human   205 IQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQ 269
            |..||.:...||:....||:|::|||:|||:|||||:||||.:||::||::.|:.:|.:|.||||
  Fly  1737 INALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVFDFLRENNYEPYPLDQVRHMAYQ 1801

Human   270 ICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHH 334
            :|.|:.|||.|:||||||||||||||.|||...||.|:.|:.|.:||||::::||||||:|.|||
  Fly  1802 LCYSVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLIDFGSATFDHEHH 1866

Human   335 STLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIP-- 397
            ||:|||||||||||||.||||||||||||||||.|.|||.|:|||||::|||||||||||.||
  Fly  1867 STIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQTHDNREHLAMMERILGQIPYR 1931

Human   398 ---QHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYD 459
               .|.:....|.|||:|.:|||||.||||||||..||||....|...|:|.:||.|:::||||:
  Fly  1932 MARNHTLYSKTKTKYFYHGKLDWDEKSSAGRYVRDHCKPLFLCQLSDSEDHCELFSLIKKMLEYE 1996

Human   460 PTQRITLDEALQHPFFDLL 478
            |:.||||.|||.|||||.|
  Fly  1997 PSSRITLGEALHHPFFDRL 2015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLK4	NP_065717.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46		8/63 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	102..143		11/66 (17%)
		PKc_CLK1_4	146..475	CDD:271115	205/333 (62%)
Doa	NP_001014681.2	PKc_CLK	1679..2012	CDD:271036	205/333 (62%)
Doa	NP_001014681.2	S_TKc	1692..2012	CDD:214567	198/320 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000672
OrthoInspector	1	1.000	-	-		otm40742
orthoMCL	1	0.900	-	-		OOG6_100708
Panther	1	1.100	-	-	O	PTHR45646
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R660
SonicParanoid	1	1.000	-	-		X440
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.800