DRSC/TRiP Functional Genomics Resources

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Protein Alignment PTGIR and tyra-3

DIOPT Version :9

Sequence 1:NP_000951.1 Gene:PTGIR / 5739 HGNCID:9602 Length:386 Species:Homo sapiens
Sequence 2:NP_001024805.1 Gene:tyra-3 / 187427 WormBaseID:WBGene00006475 Length:592 Species:Caenorhabditis elegans


Alignment Length:259 Identity:61/259 - (23%)
Similarity:93/259 - (35%) Gaps:67/259 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    22 LMFVAGVVGNGLALGILSARRPARPSAFA-VLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLA 85
            ::.:..:.||  .|.:||.....|...|. :|:|.||..|||....:.|         .|||.|.
 Worm   108 MLILLTIFGN--ILVVLSVVVYKRMRTFTNILLTSLATADLLVGLIVMP---------MSLLDLL 161

Human    86 RG-----GPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYA 145
            ..     |..||..:|.:......||:|.|..::::|..|::.|..|.:....:.|...|.|::|
 Worm   162 HNHRWPLGRFLCRMWATSDVLLCTASILNLCVISLDRYFAITSPLKYPRTRSRKMAAGLLTAVWA 226

Human   146 FCVLFCALPLLGLGQHQQYCPGSW-CFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLS 209
            ...:.|:.|         :...|| .|:...........|..||:..||.   .|:...||..|.
 Worm   227 ISFVVCSPP---------WVIPSWNLFIDNNNNTGSSEDFKCAYSPSVAY---RIYSALGSFYLP 279

Human   210 L---------------------------CRMYR-----QQKRHQGSL----GPRPRTGEDEVDH 237
            |                           ||:..     |||..:.:|    .|..|| ..:|:|
 Worm   280 LLVMLFVYFKIFRVASEREALMRQSVGTCRLSNRLTKTQQKNQRNNLRTASAPHSRT-RVQVNH 342

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTGIRNP_000951.1 7tm_GPCRs 14..304 CDD:333717 61/259 (24%)
TM helix 1 16..40 CDD:320095 4/17 (24%)
TM helix 2 50..72 CDD:320095 8/22 (36%)
TM helix 3 93..115 CDD:320095 5/21 (24%)
TM helix 4 138..154 CDD:320095 4/15 (27%)
TM helix 5 181..204 CDD:320095 6/22 (27%)
TM helix 6 235..260 CDD:320095 2/3 (67%)
TM helix 7 271..296 CDD:320095
tyra-3NP_001024805.1 7tmA_tyramine_R-like 101..>300 CDD:320189 50/214 (23%)
TM helix 1 102..126 CDD:320189 5/19 (26%)
TM helix 2 135..157 CDD:320189 8/30 (27%)
TM helix 3 174..196 CDD:320189 5/21 (24%)
TM helix 4 219..235 CDD:320189 4/15 (27%)
TM helix 5 265..288 CDD:320189 7/25 (28%)
7tm_GPCRs <486..564 CDD:391938
TM helix 6 488..518 CDD:341315
TM helix 7 532..557 CDD:341315
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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