DRSC/TRiP Functional Genomics Resources

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Protein Alignment PTGIR and srx-18

DIOPT Version :9

Sequence 1:NP_000951.1 Gene:PTGIR / 5739 HGNCID:9602 Length:386 Species:Homo sapiens
Sequence 2:NP_507493.2 Gene:srx-18 / 183532 WormBaseID:WBGene00005909 Length:293 Species:Caenorhabditis elegans


Alignment Length:319 Identity:66/319 - (20%)
Similarity:118/319 - (36%) Gaps:68/319 - (21%)


- Green bases have known domain annotations that are detailed below.


Human     8 LTYVRGSVGPATSTLMFVAGVVGNGL--ALGILSARRPARPSAFAVLVTGLAATDLL---GTSFL 67
            :|::..|||...:..:|::....:.:  :.|.::..:       ||..|.:....||   ...|.
 Worm    10 ITFLITSVGTLANIAVFISTFKISSMKSSFGTINKNQ-------AVCNTIMCLIFLLYVCPMQFS 67

Human    68 SPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDG 132
            ...:|:.|   |.:||            |.||..:.::.:..|.. |:.|..|:..|:.|.:|..
 Worm    68 DSTIFIQY---SHILG------------ASAMAAYEISHLSHLLT-ALNRFCAVFFPFYYEKLFS 116

Human   133 PRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCF--------LRMRWAQPGGAAFSLAYA 189
            .....:.:.||:...::||.|....:|....|...:|.|        .::.|.    ..|.|...
 Worm   117 KIGTIIMIQAIWIVSIIFCVLFYEIIGCLFTYDDVTWTFGFLTTQKCSQLTWY----TDFILNTV 177

Human   190 GLVALLVAAIFLC--NGSVTLSL-----CRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVV 247
            .::..:|..:...  .|..:.||     .:|.|:||  |..||...:|           .|..:.
 Worm   178 MIIVTIVVNLLTAFKAGKNSRSLMNAAGIQMSRRQK--QRELGFIKQT-----------FLQGIS 229

Human   248 MAVCSLPLTIRCFT-QAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKL 305
            |....       || ..|||..|:.:...|....:||...:|..:.::..|.:.:..||
 Worm   230 MFAGQ-------FTYYLVAPLLSNPVLLFLLASLWAFMHAVDGLIILISNKEMLEVCKL 281

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTGIRNP_000951.1 7tm_GPCRs 14..304 CDD:333717 63/310 (20%)
TM helix 1 16..40 CDD:320095 3/25 (12%)
TM helix 2 50..72 CDD:320095 6/24 (25%)
TM helix 3 93..115 CDD:320095 4/21 (19%)
TM helix 4 138..154 CDD:320095 4/15 (27%)
TM helix 5 181..204 CDD:320095 3/24 (13%)
TM helix 6 235..260 CDD:320095 2/24 (8%)
TM helix 7 271..296 CDD:320095 4/24 (17%)
srx-18NP_507493.2 TM helix 1 10..32 CDD:341315 5/21 (24%)
7TM_GPCR_Srx 12..272 CDD:370981 62/306 (20%)
TM helix 2 39..65 CDD:341315 6/32 (19%)
TM helix 3 77..106 CDD:341315 9/41 (22%)
TM helix 4 119..138 CDD:341315 4/18 (22%)
TM helix 5 164..188 CDD:341315 4/27 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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