DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PTGIR and ser-2

DIOPT Version :9

Sequence 1:	NP_000951.1	Gene:	PTGIR / 5739	HGNCID:	9602	Length:	386	Species:	Homo sapiens
Sequence 2:	NP_001024339.1	Gene:	ser-2 / 182110	WormBaseID:	WBGene00004777	Length:	455	Species:	Caenorhabditis elegans

Alignment Length:	221	Identity:	53/221 - (23%)
Similarity:	94/221 - (42%)	Gaps:	12/221 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    15 VGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAY-ARN 78
            :|..|..::....||||.|.:..:.:.||.:......||: |||:||....|:.|...|.: |..
Worm    59 LGTITYLVIIAMTVVGNTLVVVAVFSYRPLKKVQNYFLVS-LAASDLAVAIFVMPLHVVTFLAGG 122

Human    79 SSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAI 143
            ..|||:     .:|..|..|......:|:|.|.|:|::|..|:.:|..|||....:...:.:..:
Worm   123 KWLLGV-----TVCQFFTTADILLCTSSILNLCAIALDRYWAIHNPINYAQKRTTKFVCIVIVIV 182

Human   144 YAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTL 208
            :...:|....|::|....|:......|.|.   .:.....||.|.:..:.|||..:...  .:.:
Worm   183 WILSMLISVPPIIGWNNWQENMMEDSCGLS---TEKAFVVFSAAGSFFLPLLVMVVVYV--KIFI 242

Human   209 SLCRMYRQQKRHQGSLGPRPRTGEDE 234
            |..:..|..:.....:..:...|:|:
Worm   243 SARQRIRTNRGRSALMRIQNAEGDDD 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTGIR	NP_000951.1	7tm_GPCRs	14..304	CDD:333717	53/221 (24%)
		TM helix 1	16..40	CDD:320095	7/23 (30%)
		TM helix 2	50..72	CDD:320095	9/21 (43%)
		TM helix 3	93..115	CDD:320095	6/21 (29%)
		TM helix 4	138..154	CDD:320095	1/15 (7%)
		TM helix 5	181..204	CDD:320095	6/22 (27%)
		TM helix 6	235..260	CDD:320095	53/221 (24%)
		TM helix 7	271..296	CDD:320095
ser-2	NP_001024339.1	7tm_1	74..423	CDD:278431	49/206 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910