Protein Alignment JPH3 and jph3b

DIOPT Version :10

• Sequence 1: NP_065706.2
• Gene: JPH3 / 57338
• HGNCID: 14203
• Length: 748
• Species: Homo sapiens
• Sequence 2: NP_001116174.2
• Gene: jph3b / 569861
• ZFINID: ZDB-GENE-060503-415
• Length: 791
• Species: Danio rerio
• Alignment Length: 802
• Identity: 533/802 - (66%)
• Similarity: 607/802 - (75%)
• Gaps: 65/802 - (8%)

Human     1 MSSGGRFNFDDGGSYCGGWEDGKAHGHGVCTGPKGQGEYTGSWSHGFEVLGVYTWPSGNTYQGTW 65
            ||:|||||||||||||||||:|||||||:||||||||||.|||||||||:|:||||||||:||||
Zfish     1 MSTGGRFNFDDGGSYCGGWEEGKAHGHGICTGPKGQGEYAGSWSHGFEVVGIYTWPSGNTFQGTW 65

Human    66 AQGKRHGIGLESKGKWVYKGEWTHGFKGRYGVRECAGNGAKYEGTWSNGLQDGYGTETYSDGGTY 130
            |||||||||:|:||||||||||||||||||||||..|...||||||:||||||||||||||||||
Zfish    66 AQGKRHGIGIENKGKWVYKGEWTHGFKGRYGVRESTGTSGKYEGTWNNGLQDGYGTETYSDGGTY 130

Human   131 QGQWVGGMRQGYGVRQSVPYGMAAVIRSPLRTSINSLRSEHTNGTA-LHPDASPA---------V 185
            |||||||||.|||||||||||||||||||||||||||||||:|||| |..|.:|.         |
Zfish   131 QGQWVGGMRHGYGVRQSVPYGMAAVIRSPLRTSINSLRSEHSNGTALLSGDRAPVAGVGGSGVLV 195

Human   186 AGSPAVSRGGFVLVAHSDSEILKSKKKGLFRRSLLSGLKLRKSESKSSLASQRSKQSSFRSEAGM 250
            .||||||||||||.|||::|:||:|||||||||||||||||||||||||||||||||||||||||
Zfish   196 VGSPAVSRGGFVLTAHSEAELLKNKKKGLFRRSLLSGLKLRKSESKSSLASQRSKQSSFRSEAGM 260

Human   251 STVSSTASDIHSTISLGEAEAELAVIEDDIDATTTETYVGEWKNDKRSGFGVSQRSDGLKYEGEW 315
            |||||.||||:|||||||.|.||.|.:||:||||||:|.||||||||:|.|||:|||||:|:|||
Zfish   261 STVSSAASDINSTISLGEGEGELPVGDDDVDATTTESYAGEWKNDKRTGCGVSRRSDGLQYQGEW 325

Human   316 ASNRRHGYGCMTFPDGTKEEGKYKQNILVGGKRKNLIPLRASKIREKVDRAVEAAERAATIAKQK 380
            ..|:||||||.||||||||||||||||||.|||||||||||||||||||||||:|::||.|||||
Zfish   326 LGNKRHGYGCTTFPDGTKEEGKYKQNILVSGKRKNLIPLRASKIREKVDRAVESADKAADIAKQK 390

Human   381 AEIAASRTSHSRAKAEAALTAAQKAQEEARIARITAKEFSPSFQHRENGLEYQRPKRQTSCD-DI 444
            ||||.|||:|:|.||:||..||||||||.|:|||||||||||||||.|.:|.||||:|.|.: |:
Zfish   391 AEIALSRTAHARGKADAATAAAQKAQEECRLARITAKEFSPSFQHRGNRVECQRPKQQNSSENDV 455

Human   445 EVLSTGTPLQQESPELYRKGTTPSDLTPDDSPLQSFPTSPAATPPPAPAARNKVAHFSRQVSVDE 509
            ||:|:||   .:|.|||.||:||.|||||.||..|.|::|..:|....:.|.|.|.|.||.:|||
Zfish   456 EVISSGT---ADSTELYMKGSTPPDLTPDVSPTPSRPSTPPRSPTTKSSHRTKNARFLRQTAVDE 517

Human   510 ERGG--DIQMLLEGR----------AGDCAR-SSWGEE----QAGGSRGVRSGALRGGL--LVDD 555
            ||||  :||:|:|||          .||..| :||.||    :.|.|||...|:.|...  :.|:
Zfish   518 ERGGTQEIQVLMEGRGGGGGGGSGGGGDYLRANSWSEEKRPSRGGSSRGGSRGSSRSTTPSVQDE 582

Human   556 FR---TRGSGRKQPGNPK-----------PRERRTESPPVFTWTSHHRASNHSPGGSRLLELQEE 606
            .|   .|.:|.|...|.|           |||||.:.|.. :||| .|....|...|||||..||
Zfish   583 VRVGAARANGHKHSSNHKPRDHSSSNHKTPRERRPDGPSA-SWTS-QRVHGDSLAHSRLLEQDEE 645

Human   607 KLSNYRMEMKPLLRMETHPQKRRYSKGGACRGLGDDHRPEDRGFGVQRLRSKAQNKE-NFRPASS 670
            |||||.|||:||..|::|..::.|..|....|     ..|.|...:|| |.|.:::| :.|.||.
Zfish   646 KLSNYEMEMRPLQPMDSHNSQKPYGHGEERHG-----HSETRAHTLQR-RGKNRDRERDVRDASG 704

Human   671 --------AEPAVQKLASLRLG-GAEPRLLRWDLTFSPPQKSLPVALESDEENGDELKSSTGSAP 726
                    |..:||||.|||:| ..|.|.||.|||.||||||.|:|||.|:||..:||.::||..
Zfish   705 HRDTREGPALDSVQKLDSLRVGEKLEARPLRRDLTLSPPQKSPPIALEHDDENQSQLKVNSGSNS 769

Human   727 ILVVMVILLNIGVAILFINFFI 748
            |||||||||||||||||::|||
Zfish   770 ILVVMVILLNIGVAILFVHFFI 791

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
JPH3	NP_065706.2	COG4642	<3..144	CDD:443680	124/140 (89%)
		MORN 1	15..37		19/21 (90%)
		MORN 2	39..60		17/20 (85%)
		MORN 3	61..82		17/20 (85%)
		MORN 4	83..105		18/21 (86%)
		MORN 5	107..129		20/21 (95%)
		MORN 6	130..152		20/21 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	230..259		27/28 (96%)
		PLN03185	287..>345	CDD:215619	46/57 (81%)
		MORN 7	288..310		17/21 (81%)
		MORN 8	311..333		16/21 (76%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	416..496		44/80 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	526..597		29/91 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	624..649		5/24 (21%)
jph3b	NP_001116174.2	None