DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PTGER3 and ptger3

DIOPT Version :9

Sequence 1:	NP_942011.1	Gene:	PTGER3 / 5733	HGNCID:	9595	Length:	418	Species:	Homo sapiens
Sequence 2:	XP_002936132.2	Gene:	ptger3 / 100495208	XenbaseID:	XB-GENE-987941	Length:	381	Species:	Xenopus tropicalis

Alignment Length:	332	Identity:	219/332 - (65%)
Similarity:	264/332 - (79%)	Gaps:	15/332 - (4%)

- Green bases have known domain annotations that are detailed below.

Human    34 RGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALT 98
            |.|:|   ...|:..:||||||::|::||.||||||||||.:|||.:||.||.|||||||.||||
Frog    32 RSNMT---ARAEEGNTVSVAFPLSMMITGLVGNALAMLLVYKSYRNKESARKHSFLLCIGSLALT 93

Human    99 DLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPH 163
            |.:|||||:|:||.||||.::|..:||||.||.||||.||:|||..||||||||:||.||||.||
Frog    94 DFIGQLLTSPIVISVYLSNRQWARVDPSGHLCPFFGLCMTMFGLCPLFIASAMAIERTLAIRTPH 158

Human   164 WYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNL 228
            ||:||||.:||:.|||.:|:.||.|||:|::||||||:||||||||||||.|       ...||:
Frog   159 WYSSHMKPKATKMVLLAIWIGVLGFALMPIIGVGQYTLQWPGTWCFISTGDG-------EAVGNI 216

Human   229 FFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSV 293
            ||||.:|.||||:|..||:|||:||.||||||:.:::.:.:|.||.|||.||.|||:||||||..
Frog   217 FFASTYACLGLLSLFTTFACNLSTIVALVSRCKRRSSTANASRQWERITLETLIQLLGIMCVLFA 281

Human   294 CWSPLLIMMLKMIFNQTSVEHCK-----THTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKIL 353
            ||||||::||||:.|.|||||||     .:||.||:|||||.|:||||||||||||||||||.||
Frog   282 CWSPLLVIMLKMMSNHTSVEHCKPKASEQNTELQKDCNFFLTAIRLASLNQILDPWVYLLLRHIL 346

Human   354 LRKFCQM 360
            ||||||:
Frog   347 LRKFCQV 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTGER3	NP_942011.1	7tm_1	65..346	CDD:278431	191/285 (67%)
ptger3	XP_002936132.2	7tmA_PGE2_EP3	44..351	CDD:320274	212/313 (68%)
		TM helix 1	46..70	CDD:320274	18/23 (78%)
		TM helix 2	84..106	CDD:320274	16/21 (76%)
		TM helix 3	126..148	CDD:320274	16/21 (76%)
		TM helix 4	171..187	CDD:320274	9/15 (60%)
		TM helix 5	215..238	CDD:320274	14/22 (64%)
		TM helix 6	269..291	CDD:320274	15/21 (71%)
		TM helix 7	318..343	CDD:320274	22/24 (92%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	377	1.000	Domainoid score	I6602
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H105703
Inparanoid	1	1.050	448	1.000	Inparanoid score	I8429
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40300
OrthoDB	1	1.010	-	-		D204108at32523
OrthoFinder	1	1.000	-	-		FOG0011267
OrthoInspector	1	1.000	-	-		oto157899
Panther	1	1.100	-	-	LDO	PTHR11866
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X8878
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.080