DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PTGER3 and ptger3

DIOPT Version :9

Sequence 1:	NP_942011.1	Gene:	PTGER3 / 5733	HGNCID:	9595	Length:	418	Species:	Homo sapiens
Sequence 2:	XP_017212135.1	Gene:	ptger3 / 100000544	ZFINID:	ZDB-GENE-120508-5	Length:	401	Species:	Danio rerio

Alignment Length:	383	Identity:	222/383 - (57%)
Similarity:	275/383 - (71%)	Gaps:	21/383 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    41 PGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLL 105
            ||....||||||.|||||::||.|||:||||||..:||::|:|||:|||||||.||||||.||||
Zfish    33 PGRSAGCGSVSVFFPITMMVTGMVGNSLAMLLVYSAYRKKENKRKRSFLLCIGSLALTDLFGQLL 97

Human   106 TTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMK 170
            |:|:||.||.:..:|:.:|||..||.|||:.||.|||..||:|||||:||||||.|||||:.:||
Zfish    98 TSPIVISVYRADMKWDRVDPSKTLCAFFGVCMTTFGLCPLFLASAMAIERALAIIAPHWYSHYMK 162

Human   171 TRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFA 235
            |..|:.||:.:|..||.|||||:.|||:||:|||||||||:||       .....||.|||:.||
Zfish   163 TSVTKQVLVIIWCLVLLFALLPIAGVGEYTLQWPGTWCFINTG-------DKDVTGNTFFATTFA 220

Human   236 FLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI 300
            .||:.:|.||.|||:.||:|||:||:.|::::|||.||.|:||||.||||||||||..||||||:
Zfish   221 ALGIFSLLVTLSCNVVTIRALVTRCKTKSSSTQSSKQWERLTTETVIQLMGIMCVLLTCWSPLLV 285

Human   301 MMLKMIFNQTSVEHC-----KTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQM 360
            :|||||...||..||     .:..|.||:|||||.|:||||||||||||||||||:||||||||:
Zfish   286 LMLKMILTHTSSHHCYSAGSLSPQELQKDCNFFLTAIRLASLNQILDPWVYLLLREILLRKFCQV 350

Human   361 RKRRLREQLICSLQNSQIQRATAHCGQVQTYRVLNREEMEVLVSSINVYTRISTVKTE 418
            .....:    |||   .:|:.|.....||..:.:..:  :|...|:||...|..|..|
Zfish   351 ASAVSK----CSL---DVQKQTQCPLDVQNKKAIQND--DVHKQSLNVENSILNVGCE 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTGER3	NP_942011.1	7tm_1	65..346	CDD:278431	178/285 (62%)
ptger3	XP_017212135.1	7tm_4	48..>238	CDD:304433	120/196 (61%)
ptger3	XP_017212135.1	7tm_1	57..336	CDD:278431	178/285 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194327282
Domainoid	1	1.000	352	1.000	Domainoid score	I5806
eggNOG	1	0.900	-	-		E33208_3BDS8
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H105703
Inparanoid	1	1.050	428	1.000	Inparanoid score	I7511
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40300
OrthoDB	1	1.010	-	-		D291739at7742
OrthoFinder	1	1.000	-	-		FOG0011267
OrthoInspector	1	1.000	-	-		oto50280
orthoMCL	1	0.900	-	-		OOG6_117024
Panther	1	1.100	-	-	LDO	PTHR11866
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X8878
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.270