Protein Alignment PTGER2 and CG7497

DIOPT Version :10

• Sequence 1: NP_000947.2
• Gene: PTGER2 / 5732
• HGNCID: 9594
• Length: 358
• Species: Homo sapiens
• Sequence 2: NP_648999.2
• Gene: CG7497 / 39966
• FlyBaseID: FBgn0036742
• Length: 412
• Species: Drosophila melanogaster
• Alignment Length: 368
• Identity: 85/368 - (23%)
• Similarity: 142/368 - (38%)
• Gaps: 87/368 - (23%)

Human    27 ISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLA 91
            |..::...||.||.:||.:|||:     ..:...:.:|.|..:....||  .|||  :::..:|.
  Fly    34 IGVIIMVLGVFGNSLALFILARK-----KLNKNSKYTLMLRCLATNNLV--ALLG--MLTTTLLK 89

Human    92 SYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAV 156
            .|...:.|.:..   |..........||.|::..:...||.||::::..|:.|.:.::.......
  Fly    90 MYLSKEVLQSFI---RVDCVGLVVWRFFGLSSGCIAAVMAAERWMALARPFIYHKHITYELIRKS 151

Human   157 LPVIYAVSLLFCSLPLLDYGQY-----------VQY--CPGTWCFIRHGRTAYLQLYATLLLLLI 208
            :..|..::::...||.:.:|.|           ::|  .||.|      ...|..|:.....||.
  Fly   152 INSILMIAVVITFLPFVGFGAYIDESNPDQLKCIRYRDAPGVW------NKTYAVLFMVFGTLLC 210

Human   209 VSVLACNFSVILNLIRMHRRSR-----------------------RSRCGPSL-------GSG-- 241
            :.::|||..|...|:.:..|||                       .|..|.:|       |||
  Fly   211 IVIVACNLFVAHTLLCVIGRSRTAKRHMHYDLVSRDKNSAISIDPESSSGTTLYQTQLSTGSGNS 275

Human   242 -RGGPGAR--RRGERVSMAE------ETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWD 297
             |....||  |....|:||.      |.....|:|.::|:|.:|.:|..|...:....:|....:
  Fly   276 HRSVQPARQYRHSVSVTMAATDSSPVEIKFAKLMAFLSISFVICWMPQMIAIPLAIAPNRVPASN 340

Human   298 --------LQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCC 332
                    |.||.|.|     ||:|:.:.|...:..  |:|.|
  Fly   341 KFFIIADVLTALHFTS-----DPYVYVLSRSKSINW--SLLGC 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTGER2	NP_000947.2	7tmA_PGE2_EP2	22..327	CDD:320267	82/361 (23%)
		TM helix 1	23..49	CDD:320267	9/21 (43%)
		TM helix 2	67..93	CDD:320267	6/25 (24%)
		TM helix 3	109..139	CDD:320267	7/29 (24%)
		TM helix 4	151..173	CDD:320267	3/21 (14%)
		TM helix 5	192..221	CDD:320267	8/28 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	231..253		10/33 (30%)
		TM helix 6	257..287	CDD:320267	9/35 (26%)
		TM helix 7	294..319	CDD:320267	8/32 (25%)
CG7497	NP_648999.2	7tm_GPCRs	34..365	CDD:475119	81/353 (23%)
		TM helix 1	34..55	CDD:410628	8/20 (40%)
		TM helix 2	68..87	CDD:410628	6/22 (27%)
		TM helix 3	99..127	CDD:410628	5/30 (17%)
		TM helix 4	150..166	CDD:410628	1/15 (7%)
		TM helix 5	195..218	CDD:410628	6/22 (27%)
		TM helix 6	306..328	CDD:410628	7/21 (33%)
		TM helix 7	340..365	CDD:410628	8/29 (28%)