DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTGER2 and nmur-3

DIOPT Version :9

Sequence 1:	NP_000947.2	Gene:	PTGER2 / 5732	HGNCID:	9594	Length:	358	Species:	Homo sapiens
Sequence 2:	NP_001024524.1	Gene:	nmur-3 / 184090	WormBaseID:	WBGene00017176	Length:	445	Species:	Caenorhabditis elegans

Alignment Length:	411	Identity:	78/411 - (18%)
Similarity:	145/411 - (35%)	Gaps:	137/411 - (33%)

- Green bases have known domain annotations that are detailed below.

Human     2 GNASNDSQSEDCETRQWLPPGESPAISSVMF----SAGVLGNLIALALLARRWRGDVGCSAGRRS 62
            |...|:|.::....|.:|.|     |.:::|    ..|::|||:.:.::.:           ..|
Worm    57 GEQFNNSSNQLLLDRAFLNP-----ILTLIFVFVGLVGLIGNLLTVIVIFK-----------TNS 105

Human    63 SLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFA------MTFFSL 121
            ..|..:..:..|..:|.   |||  ||..|:    .||.:..:......|.:.      ::.|:.
Worm   106 LHSHTNYFLANLATSDF---CLI--VVGVSF----DLVNIWNDEEPLDIFGYCSLTSTFISLFTF 161

Human   122 ATMLMLFAMALERYLSIGHPY-----FYQRRVSR----SGGLAVLPVIYAVSLL------FCS-- 169
            |::|.:..:..||:.:|.:|:     |.::||.|    ...:|:||.|:..|:.      ||.
Worm   162 ASILTIVLLTAERFTAICYPFSHRTIFDEKRVKRFILLIWFVALLPSIFIGSMFKRVSQDFCGFN 226

Human   170 --------------------------------LPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYAT 202
                                            |||.    ::.||             |.::..|
Worm   227 RQMTYIGRCDLVTSPDSFFRYPFESAITITFVLPLF----FIIYC-------------YFRILGT 274

Human   203 LLLLLIVSVLACNFSVILNL--IRMHRRSRRSRCGPSLGSGRGGPGA------------------ 247
            ...|.|    ..|.|...|:  :.::..|..:.....:|:.|...||
Worm   275 RHFLCI----TVNLSYTSNIFPVTLNEMSNSTHVHTPVGTARSDSGAFPFPHTSNNSNTQSFPLT 335

Human   248 -RRRGERVSMAEETDHLILLAIMTIT--FAVCSLPF----TIFAYMNETSSRKEKWDLQALRFLS 305
             ..:..:...:::...:::..::|:|  |.||.||:    .|..|.::..|..:...|    ...
Worm   336 VHTKNVQPPRSQQAQKMVIKMLVTVTAVFFVCYLPYHAQRLIVKYNSKDCSNSDFCKL----LYP 396

Human   306 INSIIDPWVFAILRPPVLRLM 326
            |..|:. ::.|.|.|....||
Worm   397 IAGILQ-YISASLNPIFYNLM 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTGER2	NP_000947.2	7tm_1	38..314	CDD:278431	64/357 (18%)
PTGER2	NP_000947.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	231..253		4/40 (10%)
nmur-3	NP_001024524.1	7tmA_NTSR-like	76..424	CDD:320110	73/392 (19%)
		TM helix 1	78..102	CDD:320110	5/23 (22%)
		TM helix 2	111..133	CDD:320110	8/30 (27%)
		TM helix 3	150..172	CDD:320110	3/21 (14%)
		TM helix 4	195..211	CDD:320110	5/15 (33%)
		TM helix 5	246..269	CDD:320110	5/39 (13%)
		TM helix 6	351..376	CDD:320110	7/24 (29%)
		TM helix 7	392..417	CDD:320110	8/30 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910