DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PTGDR and ptger2b

DIOPT Version :9

Sequence 1:	NP_000944.1	Gene:	PTGDR / 5729	HGNCID:	9591	Length:	359	Species:	Homo sapiens
Sequence 2:	NP_001025421.1	Gene:	ptger2b / 570410	ZFINID:	ZDB-GENE-040724-267	Length:	341	Species:	Danio rerio

Alignment Length:	362	Identity:	137/362 - (37%)
Similarity:	204/362 - (56%)	Gaps:	41/362 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     1 MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSVFYMLV 65
            |.|....|:...|| .|.|..:...:||||:|||::||.||.       .||..:| .|:|::||
Zfish     1 MASQNVSCREQISV-SGGSPTIPAFMFSTGVLGNVVALILLE-------MRRRKQP-ASLFHVLV 56

Human    66 CGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSL-CQAFAFFMSFFGLSSTLQLLAMALE 129
            ..|.:|||||...|||:||.||.:|.||..:.   :|.| |..||:.|:||.:.:...||:||:|
Zfish    57 SSLVITDLLGTFSLSPLVLTAYFRNASLLGMN---ENRLACGHFAYAMTFFSVVTLAILLSMAVE 118

Human   130 CWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQMVHEEGSL 194
            .|||:||||||.::.:.|.|.:...::......||..||:||||:|||||||||||.|  :..:.
Zfish   119 RWLSIGHPFFYEKYSSKRCGYITIALIYLLCALFCVTPFLGFGKYVQYCPGTWCFIDM--DPSAS 181

Human   195 SVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCTRDCAEPRADGREASPQPLE 259
            ....::::|:|.:.|:::.|||||...:.::..|:|||:.| ||..|     |..|.:......:
Zfish   182 EHKAFNIIYASCLLLMIVCTVLCNASVIYHISRMYRRLKAH-RSSVR-----RQRGHKRHRSMTK 240

Human   260 ELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTSEEAEDLRALRFLSVISIVDPWIFI 324
            |::||:||..||:.|..||||::.:.|:..... ::::|     .::..|.|||...|:|||:||
Zfish   241 EVEHLVLLWFMTIAFVFCSLPLVIQVYHNTLYH-RDRHR-----NNVIPLLFLSANPIIDPWVFI 299

Human   325 IFRSPVFRIFFHKI--------------FIRPLRYRS 347
            |...||.|:.:.||              .|.|:.|.|
Zfish   300 ILSPPVPRLLWDKICKAAKSKPIREKVHSIHPVLYHS 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTGDR	NP_000944.1	7tmA_PGD2	17..335	CDD:320268	126/318 (40%)
		TM helix 1	18..44	CDD:320268	12/25 (48%)
		TM helix 2	61..87	CDD:320268	14/25 (56%)
		TM helix 3	105..135	CDD:320268	14/29 (48%)
		TM helix 4	147..169	CDD:320268	5/21 (24%)
		TM helix 5	195..224	CDD:320268	8/28 (29%)
		TM helix 6	258..288	CDD:320268	13/29 (45%)
		TM helix 7	302..327	CDD:320268	11/24 (46%)
ptger2b	NP_001025421.1	7tm_4	26..>238	CDD:304433	96/230 (42%)
ptger2b	NP_001025421.1	7tm_1	32..297	CDD:278431	112/289 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D305898at7742
OrthoFinder	1	1.000	-	-		FOG0000857
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10330
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.950