DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PTGDR and ntr-2

DIOPT Version :9

Sequence 1:	NP_000944.1	Gene:	PTGDR / 5729	HGNCID:	9591	Length:	359	Species:	Homo sapiens
Sequence 2:	NP_510477.1	Gene:	ntr-2 / 184471	WormBaseID:	WBGene00008808	Length:	398	Species:	Caenorhabditis elegans

Alignment Length:	396	Identity:	81/396 - (20%)
Similarity:	158/396 - (39%)	Gaps:	81/396 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    10 NTTSV-EKGNSAVMGGVLF---------STGLLGNLLALGLLARSGLGWCSRRPLRPLPSVFYML 64
            ||.:: .:..:|.|..:.|         ...|||||..|.::.|:  ....:|.:.|:    .:|
Worm     4 NTLNITNQRTAAAMSQIYFLVVYQTAVMIVSLLGNLFLLFVIFRA--NQVMKRRVSPV----QLL 62

Human    65 VCGLTVTDLLGKCLLS----PVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSSTLQLLA 125
            :....|.||| ..|||    .:.|..|.|...        .|.:|:...:...|...:|...|:|
Worm    63 IIHTCVADLL-FALLSLGTEILTLRTYPQYYG--------SNFVCKLMRYVQMFPMYASPFLLVA 118

Human   126 MALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQMVHE 190
            ::.:.:.::..|..:.|....|....:|.:  |:.||. .|....|..:.::.....|  ..::.
Worm   119 ISADRYQAICRPLAHFRSSRYRRPNWMAAI--AWGLAL-VLSIPQFFVWTKHSKTGRC--STIYG 178

Human   191 EGSLSV-LGYSVLYSSLMALL--VLATV----LC---NLGAMRNLYAM--HRRLQRHPRSCTRDC 243
            :...:| :.|.:::::|..||  :||.|    :|   .|.:.:::.||  .:|..::....|.|.
Worm   179 QNKNTVKITYVIMFNTLAWLLPSILAAVFYYCVCKAVRLSSTKSVRAMDSQKRNGKYSSGATEDY 243

Human   244 AEPRADGREASPQPLEELDH------LLLLALMTVLFTM----CSLPVIYRAYYGAFKDVKEKNR 298
            .|......:...|.:.|.|.      .|.:.::...|.:    |.:.||...:
Worm   244 IEELRKKSKGFRQQMSEFDRKRVQTVRLTITIVACNFFLWMPFCLINVIQALW------------ 296

Human   299 TSEEAEDLRALRFLSVI----SIVDPWIFIIF-RSPVFRIF--FHKIFIRPLRYRS----RCSNS 352
              .|...:..:.:::::    |.::|||:|:| ||.|.:..  ..:.|....:.||    .||::
Worm   297 --PEISHIMFINYVAILGNLNSCLNPWIYILFNRSHVRKALCRSRRSFTEVTKKRSFENFECSST 359

Human   353 TNMESS 358
            ..|.::
Worm   360 ATMNNN 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTGDR	NP_000944.1	7tmA_PGD2	17..335	CDD:320268	73/359 (20%)
		TM helix 1	18..44	CDD:320268	9/34 (26%)
		TM helix 2	61..87	CDD:320268	9/29 (31%)
		TM helix 3	105..135	CDD:320268	5/29 (17%)
		TM helix 4	147..169	CDD:320268	6/21 (29%)
		TM helix 5	195..224	CDD:320268	10/38 (26%)
		TM helix 6	258..288	CDD:320268	7/39 (18%)
		TM helix 7	302..327	CDD:320268	7/29 (24%)
ntr-2	NP_510477.1	7tm_1	37..323	CDD:278431	62/319 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910