Protein Alignment PTEN and TEP1

DIOPT Version :10

• Sequence 1: NP_001291646.4
• Gene: PTEN / 5728
• HGNCID: 9588
• Length: 576
• Species: Homo sapiens
• Sequence 2: NP_014271.3
• Gene: TEP1 / 855595
• SGDID: S000005072
• Length: 434
• Species: Saccharomyces cerevisiae
• Alignment Length: 398
• Identity: 91/398 - (22%)
• Similarity: 160/398 - (40%)
• Gaps: 98/398 - (24%)

Human   177 IIKEIVSRNKRRYQED-GFDLDLTYIYPNIIAMGFPAERL-EGVYRNNIDDVVRFLDSKH-KNHY 238
            ::|:|:|...::.:.| |..||::||..|:|...:|.... :.:|||::||::.||...| |.::
Yeast    22 LMKKILSLPMKKTKNDIGLRLDISYILVNLIVCSYPVNTYPKLLYRNSLDDLILFLTVYHGKGNF 86

Human   239 KIYNLCAERHYDTAKFN------CRVAQYPFE--------------------------------- 264
            :|:|...|:.....|.|      .:.....||
Yeast    87 RIFNFRGEKEDSDYKDNDLIGIAAKFESKDFEIQELRSTLINDGKIPISPIDLETRTLVEEETNN 151

Human   265 ---------DHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLK 320
                     ||.||..||::...:.::.:||...|.||.:||:.||||:|::..|||:   |:|:
Yeast   152 VICERIGWLDHFPPPFELLEEIVDGIENYLSVSKNRVAVLHCRMGKGRSGMITVAYLM---KYLQ 213

Human   321 AQEALDFYGEVR-----TRDK----KGVTIPSQRRYVYYYSYLLKNH------LDYRPVALLFH- 369
            ..     .||.|     .|.|    .|||||||.||:.|:.:.:.:.      :....|...|.
Yeast   214 CP-----LGEARLIFMQARFKYGMTNGVTIPSQLRYLRYHEFFITHEKAAQEGISNEAVKFKFKF 273

Human   370 ---KMMFETIPMFSGGTCNPQFVVCQLKVKIYSS--NSGPTRREDKFMYFEFPQPLPVCGDIKVE 429
               ||.|    :........:..:...|::.|:.  |:..||   |.:|.:.  ....||.....
Yeast   274 RLAKMTF----LRPSSLITSESAIVTTKIQHYNDDRNALLTR---KVVYSDI--MAHECGGNMTF 329

Human   430 FFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLC-----DQEIDSICSIERADNDKEYL 489
            .|.:....|:.|....|.:.|    ...:.:..:.:.:.|     :..::::..|.:.|:..:|.
Yeast   330 IFGRDYLTLENDCRIEFTLGT----SKSKAASSIISWTSCASCWLNIYLETLMHIIKDDSSPDYF 390

Human   490 VLTLTKND 497
            .:...|.|
Yeast   391 QVERLKRD 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTEN	NP_001291646.4	PTP_PTEN	197..354	CDD:350359	60/215 (28%)
		PTEN_C2	361..522	CDD:463081	25/148 (17%)
TEP1	NP_014271.3	PTP_PTEN-like	43..251	CDD:350347	60/215 (28%)