Protein Alignment PTEN and Pten

DIOPT Version :9

• Sequence 1: NP_001291646.4
• Gene: PTEN / 5728
• HGNCID: 9588
• Length: 576
• Species: Homo sapiens
• Sequence 2: NP_001162933.1
• Gene: Pten / 43991
• FlyBaseID: FBgn0026379
• Length: 514
• Species: Drosophila melanogaster
• Alignment Length: 438
• Identity: 173/438 - (39%)
• Similarity: 239/438 - (54%)
• Gaps: 86/438 - (19%)

Human   174 MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPA-ERLEGVYRNNIDDVVRFLDSKHKNH 237
            |:.:|:.:||:.:.||:|.|:|||||||..||||||:|| ::|||::||.::||.:.|:..|..|
  Fly     8 MSNVIRNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQH 72

Human   238 YKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKG 302
            |||||||:||.||.|||..|||.|||:|||||.:|||:.||.|:|.||.||.::|.|:|||||||
  Fly    73 YKIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKG 137

Human   303 RTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALL 367
            |||.||||||:..|....|.|||.:|.|.||:|:||||||||||||.|:|.|:.:.:.|..|:|.
  Fly   138 RTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKLVCSSVPYSKVSLN 202

Human   368 FHKMMFETIPMFSGGTC--NPQFVVCQLKVKIYSS---NSGPTRRE------DKFMYFEFPQPLP 421
            ..::      .||..:|  |...|.|.:.| ::.|   |:.|.|.:      .|.........:|
  Fly   203 VCEI------RFSESSCVQNLGMVECSISV-LHDSATENAKPDRLKTLPIDFQKSFVLTIKPSIP 260

Human   422 VCGDIKVEFFHKQNKMLKKDKMF-HFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADND 485
            |.||:|.|...|     ..||:. |||:||||          |.|.|.|:           :|..
  Fly   261 VSGDVKFELTKK-----SPDKIICHFWLNTFF----------VRNYSPCE-----------SDGT 299

Human   486 KEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYF---------------TKTVEEPSNPEASSS 535
            ....:.||:|:::|..:||..::.||..||:.:.|               .:..|...|.|.|..
  Fly   300 VNKYIHTLSKSEIDDVHKDSEHKRFSEEFKISIVFEAENFSNDVQAEASEKERNENVLNFERSDY 364

Human   536 TSVTPD-----------VSDNEP--------DH------YRYSDTTDS 558
            .|::|:           |:||..        ||      .:|..:|:|
  Fly   365 DSLSPNCYAEKKVLTAIVNDNTTKSQTIETLDHKDIVTKIQYDTSTNS 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTEN	NP_001291646.4	None
Pten	NP_001162933.1	PTPc	58..167	CDD:304379	66/108 (61%)
		PTEN_C2	196..335	CDD:287393	46/171 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159149
Domainoid	1	1.000	118	1.000	Domainoid score	I5891
eggNOG	1	0.900	-	-		E2759_KOG2283
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H265
Inparanoid	1	1.050	283	1.000	Inparanoid score	I2874
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52467
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001369
OrthoInspector	1	1.000	-	-		oto90056
orthoMCL	1	0.900	-	-		OOG6_100936
Panther	1	1.100	-	-	LDO	PTHR12305
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1027
SonicParanoid	1	1.000	-	-		X965
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790