DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTEN and aux

DIOPT Version :9

Sequence 1:	NP_001291646.4	Gene:	PTEN / 5728	HGNCID:	9588	Length:	576	Species:	Homo sapiens
Sequence 2:	NP_649438.1	Gene:	aux / 40527	FlyBaseID:	FBgn0037218	Length:	1165	Species:	Drosophila melanogaster

Alignment Length:	506	Identity:	112/506 - (22%)
Similarity:	182/506 - (35%)	Gaps:	120/506 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   101 PLAAEEKQAQSLQPSSSRRSSHYPAAVQSQAAAERGASATAKSRAISILQKKPRHQQLLPSL--S 163
            ||.......:||...|..:||.|........:|...:|...             |..||.||  .
  Fly   333 PLDLHIMPIESLPAESPLKSSAYSEVYTEPLSAAIPSSYNG-------------HGSLLSSLRGG 384

Human   164 SFFFSHRLPDMTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYR-NNIDDVV 227
            :......:.|.:..:.:.:.::..|.     |||:::|...|:.|..|::..|..|: |||:||.
  Fly   385 AGTLLKNIKDTSTKVMQTMQQSLARN-----DLDISHITSRILVMPCPSDGFESTYKTNNIEDVR 444

Human   228 RFLDSKH-KNHYKIYNLCAERHYDTAKFNCRVAQ----YPFEDHNPPQLELIKPFCEDLDQWLSE 287
            ..|:|:. .....|||. .:|.........|..:    |.....:.|.|:.:.....|:..:|:.
  Fly   445 LSLESRFVPQKLSIYNF-GQRTEPRLPPPVRTVEAGSVYGCPQAHAPNLQGLFTVSADMYNFLNA 508

Human   288 DDNHVAAIHCKAGKGRT-GVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTI---PSQRRYV 348
            |...|..:......|.| ..:|||.|::.....:.::|:..:...|.      ||   ||:.||:
  Fly   509 DPKSVVIVQTGDSGGCTAATVICALLMYADLLREPEDAVQVFAVKRH------TINLRPSEFRYL 567

Human   349 YYYSYLLKNHLDYRPVALLFH-------KMMFETIPMFSGGT----------CNPQFVVCQL--- 393
            ||:..:|      ||..||.|       .:..:.:|..:...          ||...::..|
  Fly   568 YYFGDIL------RPTPLLPHYKNTTLVSLSCQPVPRMTKARDGCRIYMEVYCNGNLLLSTLQDY 626

Human   394 -KVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKD--KMFHFWVNTFFIPG 455
             |:::|.:..|.         ...|..|..|||:.|..||.:..|::..  |:..|..||.|||.
  Fly   627 EKMRLYQAGPGK---------IVLPINLTACGDVTVVLFHARKGMVRPQGLKICQFQFNTGFIPE 682

Human   456 PEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYF 520
            ||                               .::|.|..|||.....:   ..:|.|.|.|..
  Fly   683 PE-------------------------------TLITFTNQDLDDLPDPE---QVTPRFCVSLSL 713

Human   521 TKTVEE----------PSNPEASSSTSVTPDVSDNEP-DHYRYSDTTDSDP 560
            ..|..|          |:.|:.|.:...:.|:...|. |::....:|.|.|
  Fly   714 AVTDSESPPSHKPPWMPAKPKRSPAALFSSDLEYAEMLDNFVTKPSTRSSP 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTEN	NP_001291646.4	None
aux	NP_649438.1	PKc_like	49..326	CDD:304357
		S_TKc	51..317	CDD:214567
		PTEN_C2	581..711	CDD:287393	34/172 (20%)
		DnaJ	<1110..1150	CDD:197617
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2283
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810