| Sequence 1: | NP_000255.2 | Gene: | PTCH1 / 5727 | HGNCID: | 9585 | Length: | 1447 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_523661.2 | Gene: | ptc / 35851 | FlyBaseID: | FBgn0003892 | Length: | 1286 | Species: | Drosophila melanogaster |
| Alignment Length: | 1369 | Identity: | 506/1369 - (36%) |
|---|---|---|---|
| Similarity: | 759/1369 - (55%) | Gaps: | 149/1369 - (10%) |
- Green bases have known domain annotations that are detailed below.
|
Human 48 DYLHRPSYCDAAFALEQISKGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAF 112
Human 113 AVGLKAANLETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQ 177
Human 178 HLDSALQASRVHVYMYNRQWKLEHLC-YKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKL 241
Human 242 ---QSGTAYLLGKPPLRWTNFDPLEFLEELK------KINYQVDSWEEMLNKAEVGHGYMDRPCL 297
Human 298 NPADPDCPATAPNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQT 362
Human 363 MFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNS----TQKVLSFT 423
Human 424 TTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRW-DCSKSQGAVGLAGVLLVALSVAAGLGL 487
Human 488 CSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTS 552
Human 553 ISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSP 617
Human 618 CVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPR 682
Human 683 SEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSD--SSLHCLEPPCTKWTLSSFAEKHYAPFLL 745
Human 746 KPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQ-K 809
Human 810 ADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNN-Y 873
Human 874 KNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQ 938
Human 939 ANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTS 1003
Human 1004 LGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELF 1068
Human 1069 GMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVST 1133
Human 1134 LLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPSP 1198
Human 1199 EPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVIVEATENPV 1263
Human 1264 FAHSTVVHPESRHHPPSNPRQQPHLDSGSLPPG---------RQGQQPRRDPPREGLWPPPYRPR 1319
Human 1320 RDAF----EISTEGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVA 1380
Human 1381 VHPP 1384 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| PTCH1 | NP_000255.2 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..43 | ||
| 2A060602 | 43..1206 | CDD:273338 | 469/1176 (40%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1189..1234 | 13/44 (30%) | |||
| PHA03377 | <1253..1369 | CDD:177614 | 21/128 (16%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1270..1360 | 18/102 (18%) | |||
| ptc | NP_523661.2 | 2A060602 | 17..1134 | CDD:273338 | 471/1180 (40%) |
| MMPL | 454..598 | CDD:304422 | 77/149 (52%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C165154929 | |
| Domainoid | 1 | 1.000 | 297 | 1.000 | Domainoid score | I1467 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG1935 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 1 | 1.000 | - | - | H223 | |
| Inparanoid | 1 | 1.050 | 866 | 1.000 | Inparanoid score | I426 |
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 1 | 1.010 | - | - | QHG49297 | |
| OrthoDB | 1 | 1.010 | - | - | D1190129at2759 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0003078 | |
| OrthoInspector | 1 | 1.000 | - | - | otm41186 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_105508 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR46022 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R2737 |
| SonicParanoid | 1 | 1.000 | - | - | X2446 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 16 | 15.800 | |||||