DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Brd4 and tbrd-3

DIOPT Version :9

Sequence 1:	NP_001273559.1	Gene:	Brd4 / 57261	MGIID:	1888520	Length:	1401	Species:	Mus musculus
Sequence 2:	NP_726307.1	Gene:	tbrd-3 / 246604	FlyBaseID:	FBgn0050417	Length:	268	Species:	Drosophila melanogaster

Alignment Length:	330	Identity:	94/330 - (28%)
Similarity:	141/330 - (42%)	Gaps:	83/330 - (25%)

- Green bases have known domain annotations that are detailed below.

Mouse   347 EKSSKISEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLES 411
            :::.:.|.::..|..|:|.:|:..:...||.||:|:|.:.||||||.:|::.|||:||::.:|.:
  Fly     5 QETERSSPEINACKVIIKRLFSSTYKNIAWVFYEPLDPQLLGLHDYHEIVREPMDLSTVRHRLNT 69

Mouse   412 REYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVTVSSPAVP 476
            ..|..|.:|..|:||:|.|.|.|..|||....||::||.:||..::::      .:...||
  Fly    70 GCYLSAADFAKDIRLIFYNTYLYTNPDHLCYHMAKQLQIIFEEMYSQV------QLYICSS---- 124

Mouse   477 PPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKK 541
             .:||.|...||...|||||..|
  Fly   125 -GSKVRAEEESSSDESDSSSPED------------------------------------------ 146

Mouse   542 EKDKKEKKKEKHKKKEEVEENKKSKT-KELPPKKTKKNNSSNSNVSKKEPVPTKTKPPPTYESEE 605
                            ||..::.|.: ...||..|.....:        |.|..| ||.|.|:.|
  Fly   147 ----------------EVNGSEVSPSIMGAPPSCTPTTECT--------PTPDWT-PPATLETSE 186

Mouse   606 EDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELE 670
            :.  :|.:.||...|...|.:|.||.|..|:|.||..| ..:..| .|:|.|...||..|.|.:.
  Fly   187 QQ--EPFTTEEDLDLHAKIQQLDGEVLLHVIHFIQRME-GAEYCN-KELEFDICKLKVHTKRGIR 247

Mouse   671 RYVTS 675
            .|:.|
  Fly   248 DYLAS 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brd4	NP_001273559.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58
		Bromo_Brdt_I_like	58..164	CDD:99929
		Bromo_Brdt_II_like	355..456	CDD:99930	42/100 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	462..617		29/155 (19%)
		NPS region. /evidence=ECO:0000250	486..505		8/18 (44%)
		BID region. /evidence=ECO:0000250	526..581		6/55 (11%)
		BET	611..675	CDD:407211	23/63 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	676..1126		94/330 (28%)
		PHA03247	<793..1231	CDD:223021
		C-terminal (CTD) region. /evidence=ECO:0000250	1051..1401
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1156..1378
		TPH	<1267..1308	CDD:404709
		BRD4_CDT	1359..1401	CDD:407248
tbrd-3	NP_726307.1	Bromo_Brdt_II_like	13..114	CDD:99930	42/100 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000322
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22880
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X197
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.910