DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment arvcfa and p120ctn

DIOPT Version :9

Sequence 1:	XP_701001.5	Gene:	arvcfa / 572216	ZFINID:	ZDB-GENE-091113-43	Length:	819	Species:	Danio rerio
Sequence 2:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster

Alignment Length:	836	Identity:	297/836 - (35%)
Similarity:	420/836 - (50%)	Gaps:	129/836 - (15%)

- Green bases have known domain annotations that are detailed below.

Zfish     7 DPEELPTQPSSPDNPEQEIVQETADSPSSDAVAEAHTESSGIGTEKSSSPDSESNPLSSSSSNEQ 71
            :|..:.:|..|..|.:|......:.:|.      ..|:.:|:|.....:|....|.:.::|::..
  Fly    29 EPANMQSQFGSFQNYDQFSAAGYSSTPL------YITKPTGVGAITKVAPHCSQNKIETNSTDNS 87

Zfish    72 VIPSVLKESSCEELDDSQTSSPDDQCVNQAEAPDGSPETEDLPPHPEPSLTSDPAKEDLKDPLAL 136
             ||.:             .:.|....|...:|    .:.||...:....||.....|...:.:..
  Fly    88 -IPDI-------------ENHPLATTVRYVQA----GQYEDTSEYGVAGLTCGIDSEYTAEAVVP 134

Zfish   137 YSTLPAHSMTLLHGLTYHPSFPTRNYIPENCYTLPLHRDSFPNRKSEQDVSAVSHPVHHIRPTLD 201
            |                             |||            |:.:.:.:.:....|:|...
  Fly   135 Y-----------------------------CYT------------SDANYTGIQNTTSSIKPFSG 158

Zfish   202 LSADDHL------APLQHAYFQDLYRTLIPQKRASMVSLDTI-----RKDP-------------R 242
            ...:|::      |..|...|:......:||  .:|.|::|:     .||.             |
  Fly   159 RPFNDNINGAEAVADSQCRTFKSSAEFKLPQ--FAMSSINTVPQRLEEKDDYIEGSENDICSTMR 221

Zfish   243 WRDPNLREVIAMLSHPMDPVKSNAAAYLQHLCYENDKVKQDVRQLRGIPVLVGLLDHPKPEVHRK 307
            ||||||.|||:.||:|...:|:|||||||||||.:|..||..|.|.|||.||.||.:..||:|:.
  Fly   222 WRDPNLSEVISFLSNPSSAIKANAAAYLQHLCYMDDPNKQRTRSLGGIPPLVRLLSYDSPEIHKN 286

Zfish   308 ACGALRNISFGRDN-FNKVAIKNSDGIPALLRLLRKSNDVEVRELVTGTLWNLSSHEPLKMMVIN 371
            |||||||:|:||.| .||..|||:.||.||:.||.:|.:.||:|||||.|||:||.|.||..:|:
  Fly   287 ACGALRNLSYGRQNDENKRGIKNAGGIAALVHLLCRSQETEVKELVTGVLWNMSSCEDLKRSIID 351

Zfish   372 HGLQTLTDEIIIPHSGLRGDPNDPARPGDPEWNTVFKNTSGCLRNVSSDGAEARQRLRECDGLVD 436
            ..|..:...:|.||||.     |....|:..::|||:|.||.||||||.|..||..||.|:.||:
  Fly   352 EALVAVVCSVIKPHSGW-----DAVCCGETCFSTVFRNASGVLRNVSSAGEHARGCLRNCEHLVE 411

Zfish   437 ALLHALYSAVAKRDINNKSVENCVCILRNLSYHVHK-EVPGAEKFHIQAASHNAKPAGHHKKDKP 500
            .||:.:.:::.|.:|.||:|||||||||||||...: :.|..:| |.........|:. .|.:..
  Fly   412 CLLYVVRTSIEKNNIGNKTVENCVCILRNLSYRCQEVDDPNYDK-HPFITPERVIPSS-SKGENL 474

Zfish   501 DCFGGRTTKEEWFHQCKRHGAVEKKSGGADLPKRSLPM----RGLELLYQPEVVRLYLSLLKLSQ 561
            .|||....|:|    .....|:.:.:..||..|.|:..    :|.|.|:|||||:.|||||:...
  Fly   475 GCFGTNKKKKE----ANNSDALNEYNISADYSKSSVTYNKLNKGYEQLWQPEVVQYYLSLLQSCS 535

Zfish   562 NHNTLEAAAGALQNLSAGHWAWSNYIRATVRKEKGLPVLVELLHSDADKVVRAVAIALRNLAIDH 626
            |..||||||||:|||||.:|..|..||||||||||||:|||||..:.|:||.|||.||||||||.
  Fly   536 NPETLEAAAGAIQNLSACYWQPSIDIRATVRKEKGLPILVELLRMEVDRVVCAVATALRNLAIDQ 600

Zfish   627 KNKDLIGSYAMRDLVSNLPCGQQRPAKNLEGDTVVAILNTILEIISENLENARFLIQGQGIQKLV 691
            :||:|||.|||||||..||.|..:..:|...||:.|:|.||.|:|.:|.|.:|.|:...||.:|:
  Fly   601 RNKELIGKYAMRDLVQKLPSGNVQHDQNTSDDTITAVLATINEVIKKNPEFSRSLLDSGGIDRLM 665

Zfish   692 SINRTSQSVRE--TKAASHILQAVWAYKDLRHTLLKAGWNK-----THFKPAVSSLPKKLKNTKQ 749
            :|.:..:....  .|.||.:|..:|.:.:||....|.||.:     .|| .|.::.|....|.
  Fly   666 NITKRKEKYTSCVLKFASQVLYTMWQHNELRDVYKKNGWKEQDFVSKHF-TAHNTPPSSPNNV-- 727

Zfish   750 GNDDITLPLMEKNQDGYCSVDQPERAGDAPCHMIERETFQGVNDKRHFIRTSRPAV 805
             |:.:..|:..:.:..|  .|:..:.|.:        |....||....:.::..|:
  Fly   728 -NNTLNRPMASQGRTRY--EDRTIQRGTS--------TLYSANDSSGAVMSNESAM 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arvcfa	XP_701001.5	HEAT repeat	207..239	CDD:293787	8/42 (19%)
		ARM	248..361	CDD:237987	67/113 (59%)
		HEAT_2	248..350	CDD:290374	59/102 (58%)
		armadillo repeat	248..273	CDD:293788	15/24 (63%)
		armadillo repeat	281..317	CDD:293788	21/35 (60%)
		armadillo repeat	324..359	CDD:293788	20/34 (59%)
		armadillo repeat	366..417	CDD:293788	18/50 (36%)
		armadillo repeat	541..578	CDD:293788	24/36 (67%)
		ARM	542..673	CDD:237987	83/130 (64%)
		armadillo repeat	588..622	CDD:293788	25/33 (76%)
		armadillo repeat	678..715	CDD:293788	10/38 (26%)
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	67/113 (59%)
		armadillo repeat	227..252	CDD:293788	15/24 (63%)
		armadillo repeat	260..296	CDD:293788	21/35 (60%)
		armadillo repeat	304..339	CDD:293788	20/34 (59%)
		ARM	307..442	CDD:237987	70/139 (50%)
		armadillo repeat	347..392	CDD:293788	17/49 (35%)
		armadillo repeat	515..556	CDD:293788	26/40 (65%)
		ARM	516..643	CDD:237987	81/126 (64%)
		armadillo repeat	562..596	CDD:293788	25/33 (76%)
		armadillo repeat	601..641	CDD:293788	20/39 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	430	1.000	Inparanoid score	I1698
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125744at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.070