DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment VANGL2 and Vang

DIOPT Version :9

Sequence 1:	NP_065068.1	Gene:	VANGL2 / 57216	HGNCID:	15511	Length:	521	Species:	Homo sapiens
Sequence 2:	NP_001260819.1	Gene:	Vang / 35922	FlyBaseID:	FBgn0015838	Length:	608	Species:	Drosophila melanogaster

Alignment Length:	595	Identity:	259/595 - (43%)
Similarity:	352/595 - (59%)	Gaps:	88/595 - (14%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDTESQYSGYSYKSGHSRSSRKH-------------------------RDR-----RDRHRSKSR 35
            |:.||..|.:   ||.||.||.|                         |||     |..|.|||.
  Fly     1 MENESVKSEH---SGRSRRSRNHNNNGGGGGGGGGGGGGSVNNGYHRERDRSRHSHRSTHSSKSA 62

Human    36 DG-GRGD-----KSVTIQAPGEPLLDNESTRGDE--------RDDNWGETTTVVTG-TSEHSISH 85
            .| .|||     .||.:...|       |..|.|        :|:||||.||.||| |||.|||.
  Fly    63 KGFQRGDMAPYQTSVNMTGDG-------SHDGQEVIEVQILPQDENWGENTTAVTGNTSEQSISM 120

Human    86 DDLTRI-AKDMEDSVPLDCSRHLGVAAGATLALLSFLTPLAFLLLP-----PLLW---------R 135
            :|:..: .::.:......|.|::..:....|...:|.:|:|.:::|     |..:         |
  Fly   121 EDINNMWHRESDKGFSFACRRYVESSFYFLLGCGAFFSPVAMVVMPYVGFFPSAFDHPEITQTVR 185

Human   136 EELEPCGTACEGLFISVAFKLLILLLGSWALFFRRPKASLPRVFVLRALLMVLVFLLVVSYWLFY 200
            .:|..|...|:|..:|:|.:||:|.:|.||:|.||..|::||:|:.|||:::||.:...:|||||
  Fly   186 TQLLACSEQCKGQLVSLAARLLLLAIGLWAVFMRRTSATMPRIFLYRALVLLLVTICTFAYWLFY 250

Human   201 GVRILDARE---------RSYQGVVQFAVSLVDALLFVHYLAVVLLELRQLQPQFTLKVVRSTDG 256
            .|::.:..:         ..|:.:|.:|.:.||.|||:||:||||||||..||.:.:|::||.||
  Fly   251 IVQVTNGAKIVVETGGDAVDYKSLVGYATNFVDTLLFIHYVAVVLLELRHQQPCYYIKIIRSPDG 315

Human   257 ASRFYNVGHLSIQRVAVWILEKYYHDFPVYNPALLNLPKSV---LAKKVS-GFKVYSL-GEENST 316
            .||.|.:|.|||||.|||:|:.||.|||::||.|..:|.||   ...|:| .||.|.: |..||.
  Fly   316 VSRSYMLGQLSIQRAAVWVLQHYYVDFPIFNPYLERIPISVSKSQRNKISNSFKYYEVDGVSNSQ 380

Human   317 NNSTGQSRAVIAAAARRRDNSHNEYYYEEAEHERRVRKRRARLVVAVEEAFTHIKRLQEEEQKNP 381
            ..|  |||||:||.|||||:||||.:|||.|:||||:||||||:.|.|||||||||:..|..  |
  Fly   381 QQS--QSRAVLAANARRRDSSHNERFYEEHEYERRVKKRRARLITAAEEAFTHIKRIHNEPA--P 441

Human   382 REVMDPREAAQAIFASMARAMQKYLRTTKQQPYHTMESILQHLEFCITHDMTPKAFLERYLAAGP 446
            ...:||:|||.|:|.|||||:|||||.|:|||.||.||||:||..|:.||::|:||||.||...|
  Fly   442 ALPLDPQEAASAVFPSMARALQKYLRVTRQQPRHTFESILKHLAHCLKHDLSPRAFLEPYLTESP 506

Human   447 TIQYHKERWLAKQWTLVSEEPVTNGLKDGIVFLLKRQDFSLVVSTKKVPFFKLSEEFVDPKSHKF 511
            .:|..|||...:.|:|:.:|.|:..:.:...|.|.:.|.||:|:..|:|.|.|:||.|||||:||
  Fly   507 VMQSEKERRWVQSWSLICDEIVSRPIGNECTFQLIQNDVSLMVTVHKLPHFNLAEEVVDPKSNKF 571

Human   512 VMRLQSETSV 521
            |::|.|||||
  Fly   572 VLKLNSETSV 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VANGL2	NP_065068.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..81		41/124 (33%)
VANGL2	NP_065068.1	Strabismus	34..521	CDD:399556	239/530 (45%)
Vang	NP_001260819.1	Strabismus	44..581	CDD:284135	246/547 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156759
Domainoid	1	1.000	433	1.000	Domainoid score	I586
eggNOG	1	0.900	-	-		E1_KOG3814
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1687
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47940
OrthoDB	1	1.010	-	-		D1325060at2759
OrthoFinder	1	1.000	-	-		FOG0002892
OrthoInspector	1	1.000	-	-		otm41595
orthoMCL	1	0.900	-	-		OOG6_105860
Panther	1	1.100	-	-	LDO	PTHR20886
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4213
SonicParanoid	1	1.000	-	-		X2248
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800