DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment VANGL2 and vangl2

DIOPT Version :9

Sequence 1:	NP_065068.1	Gene:	VANGL2 / 57216	HGNCID:	15511	Length:	521	Species:	Homo sapiens
Sequence 2:	NP_705960.1	Gene:	vangl2 / 245949	ZFINID:	ZDB-GENE-020507-3	Length:	526	Species:	Danio rerio

Alignment Length:	526	Identity:	403/526 - (76%)
Similarity:	457/526 - (86%)	Gaps:	5/526 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDTESQYSGYSYKSGHSRSSRKHRDRRDRHRSKSRD-GGRGDKSVTIQAPGEPLLDNESTRGDER 64
            ||.|||||||||||.||||||||||||||||||||| ..|||||||||||||||||.||||||:|
Zfish     1 MDNESQYSGYSYKSSHSRSSRKHRDRRDRHRSKSRDSSSRGDKSVTIQAPGEPLLDAESTRGDDR 65

Human    65 DDNWGETTTVVTGTSEHSISHDDLTRIAKDMEDSVPLDCSRHLGVAAGATLALLSFLTPLAFLLL 129
            ||||||||||||||||||:|::||||.:|::|||.||:|.|..|......|.|.:.|||||||||
Zfish    66 DDNWGETTTVVTGTSEHSVSNEDLTRASKELEDSSPLECRRFAGPIVSGVLGLFALLTPLAFLLL 130

Human   130 PPLLWREELEPCGTACEGLFISVAFKLLILLLGSWALFFRRPKASLPRVFVLRALLMVLVFLLVV 194
            |.||||:.||||||.||||::|:|||||:||:.|||||.|..:::|||.||.|.|||.||||.|.
Zfish   131 PQLLWRDSLEPCGTPCEGLYVSLAFKLLVLLISSWALFLRPSRSTLPRFFVFRCLLMALVFLFVA 195

Human   195 SYWLFYGVRILDARERSYQGVVQFAVSLVDALLFVHYLAVVLLELRQLQPQFTLKVVRSTDGASR 259
            |||||||||:|:.|||.|:|:|.:||||||||||:.|||:||||:|.|:|.|.|||||:||||||
Zfish   196 SYWLFYGVRVLEPRERDYRGIVGYAVSLVDALLFIQYLALVLLEVRHLRPAFCLKVVRTTDGASR 260

Human   260 FYNVGHLSIQRVAVWILEKYYHDFPVYNPALLNLPKSVLAKKVSGFKVYSLGEENSTNNSTGQSR 324
            |||||||||||.|||:|:.||.|||||||||||||||:|:||:||||||||||||||||||||||
Zfish   261 FYNVGHLSIQRAAVWVLDHYYTDFPVYNPALLNLPKSILSKKMSGFKVYSLGEENSTNNSTGQSR 325

Human   325 AVIAAAARRRDNSHNEYYYEEAEHERRVRKRRARLVVAVEEAFTHIKRLQEEE----QKNPREVM 385
            |:|||||||||||||||||||||.:||||||:||||||||||||||||||::|    .|:|||||
Zfish   326 AMIAAAARRRDNSHNEYYYEEAEMDRRVRKRKARLVVAVEEAFTHIKRLQDDEAAASPKHPREVM 390

Human   386 DPREAAQAIFASMARAMQKYLRTTKQQPYHTMESILQHLEFCITHDMTPKAFLERYLAAGPTIQY 450
            |||||||||||.||||||||||||:|||||:||||:.||:|||||:|||||||||||..|||:||
Zfish   391 DPREAAQAIFAPMARAMQKYLRTTRQQPYHSMESIISHLQFCITHNMTPKAFLERYLTPGPTMQY 455

Human   451 HKERWLAKQWTLVSEEPVTNGLKDGIVFLLKRQDFSLVVSTKKVPFFKLSEEFVDPKSHKFVMRL 515
            .:|....:|||||||||||..|:.|:||.|:|.||:|||:...:||..|.|||:|||||||||||
Zfish   456 QRENGRGRQWTLVSEEPVTAALRQGLVFSLRRLDFALVVTVTPLPFLNLGEEFIDPKSHKFVMRL 520

Human   516 QSETSV 521
            ||||||
Zfish   521 QSETSV 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VANGL2	NP_065068.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..81		73/80 (91%)
VANGL2	NP_065068.1	Strabismus	34..521	CDD:399556	370/491 (75%)
vangl2	NP_705960.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..95		81/93 (87%)
		Strabismus	41..526	CDD:284135	366/484 (76%)
		PDZ-binding. /evidence=ECO:0000255	523..526		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194337489
Domainoid	1	1.000	777	1.000	Domainoid score	I866
eggNOG	1	0.900	-	-		E1_KOG3814
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H62161
Inparanoid	1	1.050	822	1.000	Inparanoid score	I3331
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG47940
OrthoDB	1	1.010	-	-		D1325060at2759
OrthoFinder	1	1.000	-	-		FOG0002892
OrthoInspector	1	1.000	-	-		oto45576
orthoMCL	1	0.900	-	-		OOG6_105860
Panther	1	1.100	-	-	LDO	PTHR20886
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4213
SonicParanoid	1	1.000	-	-		X2248
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	19	19.300