Protein Alignment ATP8B2 and CG33298

DIOPT Version :10

• Sequence 1: XP_047281955.1
• Gene: ATP8B2 / 57198
• HGNCID: 13534
• Length: 1210
• Species: Homo sapiens
• Sequence 2: NP_995666.1
• Gene: CG33298 / 2768929
• FlyBaseID: FBgn0032120
• Length: 1517
• Species: Drosophila melanogaster
• Alignment Length: 1333
• Identity: 426/1333 - (31%)
• Similarity: 662/1333 - (49%)
• Gaps: 261/1333 - (19%)

Human    13 RAQAPPSWSRK---KPSWGTE-EERRARA----------NDREYNEKFQYASNCIKTSKYNILTF 63
            |.:|||.|.|.   ..:.|.: |||..|.          ..:..:...|:..|.|:|:||.:|:|
  Fly   201 RTEAPPWWKRLTLCNYNTGDKFEERSYRTVVPNHTVPPKTPKRDHPNGQFVGNKIRTTKYTLLSF 265

Human    64 LPVNLFEQFQEVANTYFLFLLILQLIPQISSLSWFTTIVPLVLVLTITAVKDATDDYFRHKSDNQ 128
            :|.||.|||..|||.||:|:::|..:|:||:......::|::.||.:|||||..:|..|..||.:
  Fly   266 IPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKR 330

Human   129 VNNRQSQVLINGILQ---QEQWMNVCVGDIIKLENNQFVAADLLLLSSSEPHGLCYIETAELDGE 190
            :||...:| .:|..:   :.:|..:.||||:.|.||:.|.||:|||.:|:|.|:|||:|.:||||
  Fly   331 INNTTCRV-YDGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGE 394

Human   191 TNMKVRQAIPVTSELGDISKLAKFDGEVICEPPNNKLDKFSGTL-YWKENKFPLSNQNMLLRGCV 254
            ||:|.|:.:....|:..|...:||...|..:.|..||.:|.|.| :....:.|:|.:.:|||...
  Fly   395 TNLKRREVVRGFEEMQSIFVPSKFVSRVEADAPTTKLYRFHGALIHPTGERVPISTECLLLRESR 459

Human   255 LRNTEWCFGLVIFAGPDTKLMQNSGRTKFKRTSIDRLMNTLVLWIFGFLVCMGVILAIGNAIWEH 319
            |:||::..|:|::||.:||.|.|:...::||:.:::.||..|:|....|:.:.|:.|||..:|..
  Fly   460 LKNTDYIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLS 524

Human   320 EVGMRFQV-YLPWDEAVDSAFFSGFLSFWSYIIILNTVVPISLYVSVEVIRLGHSYFINWDKKMF 383
            .. ..|.| |||.::.  :|.......||:||:||..::|:||||::|:.::...:.|:.:..:|
  Fly   525 SF-THFPVPYLPPNKL--TANMESMWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLF 586

Human   384 CMKKRTPAEARTTTLNEELGQVEYIFSDKTGTLTQNIMVFNKCSINGHSYGDVFDVLGHKAELGE 448
            ..:.....|.|...:.|||||:::||:|||||||:|.|:|.:|.:||..|......|........
  Fly   587 DAETNKQTECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYSKPG 651

Human   449 RPEPVDFSFNPLADKKFLFWDPSLLEAVKIGDPHT---HEFFRLLSLCHTVM------------- 497
            .|.|      ||.....|..|.:.|.......||.   .||..:|::|:||:
  Fly   652 APAP------PLIPNDNLNSDMAQLTQGTYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNAS 710

Human   498 ----------------------------------------------------------------- 497
                                                                             
  Fly   711 GIIEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVT 775

Human   498 ----------------------------------SEE-----KNE-------------------- 503
                                              ||.     ||:
  Fly   776 PSPPPNLLFALPAQSHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKI 840

Human   504 -----------------------GELY--------YKAQSPDEGALVTAARNFGFVFRSRTPKTI 537
                                   |.:|        |:|:||||.|||.||.::.....:|:|..|
  Fly   841 TSIATFLNAKTQGKRMKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQI 905

Human   538 TVH--EMGTAITYQLLAILDFNNIRKRMSVIVRN-PEGKIRLYCKGADT----ILLDRLHHSTQE 595
            .|.  ..|....|::|.:|.|::.||.||::||. ...:|.||.||||:    :|:...|:|.:.
  Fly   906 LVSMPMAGATREYEILKVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEG 970

Human   596 LL-NTTMDHLNEYAGEGLRTLVLAYKDLDEEYYEEWAERRLQASLAQDSREDRLASIYE--EESL 657
            :| ..|...|:.||.||||.||:|.:.|:...|.:|..|..:..::.::||.||...:.  |.:|
  Fly   971 ILREQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNL 1035

Human   658 WYFQLLGATAIEDKLQQGVPETIALLTLANIKIWVLTGDKQETAVNIGYSCKMLTDDMTEVFIVT 722
               .|||||.|||:||.|||||||.|..|.|.:|||||||.|||:||.||.|:.|..|
  Fly  1036 ---TLLGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQM------- 1090

Human   723 GHTVLEVREELRKAREKMMDSSRSVGNGFTYQDKLSSSKLTSVL----EAVAGEYALVINGHSLA 783
                     ||.:...:..|::.:..|  .|...:.:.|.||.|    .....:.|||::|.:|.
  Fly  1091 ---------ELIRLTARSRDAAETAIN--FYLTDMENDKTTSTLGYGQSLRKKQRALVVDGKTLT 1144

Human   784 HALE--ADMELEFLETACACKAVICCRVTPLQKAQVVELVKKYKKAVTLAIGDGANDVSMIKTAH 846
            ..|:  :.:.|.||..:..|.:|:|||.||||||.:|::||:.....||||||||||||||:.|.
  Fly  1145 FILDPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQMAD 1209

Human   847 IGVGISGQEGIQAVLASDYSFSQFKFLQRLLLVHGRWSYLRMCKFLCYFFYKNFAFTMVHFWFGF 911
            :|||||||||:|||:|:|::..:|::|:||||.||.|.|.|:.:.:.||||||.||..:.||:..
  Fly  1210 VGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQL 1274

Human   912 FCGFSAQTVYDQYFITLYNIVYTSLPVLAMGVFDQDVPEQRSMEYPKLYEPGQLNLLFNKREFFI 976
            :||||.|.:.||.::.|||:::||||.||:||:|:.|.|...::.|.||:.|:|.:.:...:|::
  Fly  1275 YCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFWL 1339

Human   977 CIAQGIYTSVLMFFIPYGVFADATRDDGTQLADYQSFAVTVATSLVIVVSVQIGLDTGYWTAINH 1041
            .:...:|.|:::||:....:|::  |.|     ...|..|:..|.:....|...::...||.::.
  Fly  1340 ILLDALYQSLVIFFVALCAYAES--DVG-----IWEFGTTITASCLFANLVHCAIEIRSWTVLHV 1397

Human  1042 FFIWGSLAVY--FAILF---AMHSNGLFDMFPNQFRFVGNAQNTLAQPTVWLTIVLTTVVCIMPV 1101
            ..|..||..:  |||::   .|:..|:...:...|....:|.:       ||.|:|:|||.::|.
  Fly  1398 LSIVLSLGSFYLFAIVYDSVCMNCFGVRSSYWVIFVCFASAVH-------WLVIMLSTVVAVLPR 1455

Human  1102 VAFRFLRLNLKPDLSDTVRYTQLVRKKQKAQHR 1134
            :....:|::|.||.|     |:::.:.::.:.|
  Fly  1456 LLLTTVRISLCPDDS-----TKVILQSKRERSR 1483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B2	XP_047281955.1	P-type_ATPase_APLT_Dnf-like	50..992	CDD:319770	380/1133 (34%)
CG33298	NP_995666.1	P-type_ATPase_APLT_Dnf-like	252..1355	CDD:319770	380/1133 (34%)