DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8B2 and CG33298

DIOPT Version :9

Sequence 1:	NP_001354863.1	Gene:	ATP8B2 / 57198	HGNCID:	13534	Length:	1209	Species:	Homo sapiens
Sequence 2:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster

Alignment Length:	1330	Identity:	426/1330 - (32%)
Similarity:	665/1330 - (50%)	Gaps:	256/1330 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    13 RAQAPPSWSRK---KPSWGTE-EERRARA----------NDREYNEKFQYASNCIKTSKYNILTF 63
            |.:|||.|.|.   ..:.|.: |||..|.          ..:..:...|:..|.|:|:||.:|:|
  Fly   201 RTEAPPWWKRLTLCNYNTGDKFEERSYRTVVPNHTVPPKTPKRDHPNGQFVGNKIRTTKYTLLSF 265

Human    64 LPVNLFEQFQEVANTYFLFLLILQLIPQISSLSWFTTIVPLVLVLTITAVKDATDDYFRHKSDNQ 128
            :|.||.|||..|||.||:|:::|..:|:||:......::|::.||.:|||||..:|..|..||.:
  Fly   266 IPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKR 330

Human   129 VNNRQSQVLINGILQ---QEQWMNVCVGDIIKLENNQFVAADLLLLSSSEPHGLCYIETAELDGE 190
            :||...:| .:|..:   :.:|..:.||||:.|.||:.|.||:|||.:|:|.|:|||:|.:||||
  Fly   331 INNTTCRV-YDGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGE 394

Human   191 TNMKVRQAIPVTSELGDISKLAKFDGEVICEPPNNKLDKFSGTL-YWKENKFPLSNQNMLLRGCV 254
            ||:|.|:.:....|:..|...:||...|..:.|..||.:|.|.| :....:.|:|.:.:|||...
  Fly   395 TNLKRREVVRGFEEMQSIFVPSKFVSRVEADAPTTKLYRFHGALIHPTGERVPISTECLLLRESR 459

Human   255 LRNTEWCFGLVIFAGPDTKLMQNSGRTKFKRTSIDRLMNTLVLWIFGFLVCMGVILAIGNAIWEH 319
            |:||::..|:|::||.:||.|.|:...::||:.:::.||..|:|....|:.:.|:.|||..:|..
  Fly   460 LKNTDYIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLS 524

Human   320 EVGMRFQV-YLPWDEAVDSAFFSGFLSFWSYIIILNTVVPISLYVSVEVIRLGHSYFINWDKKMF 383
            .. ..|.| |||.::.  :|.......||:||:||..::|:||||::|:.::...:.|:.:..:|
  Fly   525 SF-THFPVPYLPPNKL--TANMESMWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLF 586

Human   384 CMKKRTPAEARTTTLNEELGQVEYIFSDKTGTLTQNIMVFNKCSINGHSYGDVFDVLGHKAELGE 448
            ..:.....|.|...:.|||||:::||:|||||||:|.|:|.:|.:||..|......|........
  Fly   587 DAETNKQTECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYSKPG 651

Human   449 RPEPVDFSFNPLADKKFLFWDPSLLEAVKIGDPHT---HEFFRLLSLCHTVM------------- 497
            .|.|      ||.....|..|.:.|.......||.   .||..:|::|:||:
  Fly   652 APAP------PLIPNDNLNSDMAQLTQGTYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNAS 710

Human   498 ----------------------------------------------------------------- 497

  Fly   711 GIIEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVT 775

Human   498 ----------------------------------SEE-----KNE-------------------- 503
                                              ||.     ||:
  Fly   776 PSPPPNLLFALPAQSHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKI 840

Human   504 -----------------------GELY--------YKAQSPDEGALVTAARNFGFVFRSRTPKTI 537
                                   |.:|        |:|:||||.|||.||.::.....:|:|..|
  Fly   841 TSIATFLNAKTQGKRMKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQI 905

Human   538 TVH--EMGTAITYQLLAILDFNNIRKRMSVIVRN-PEGKIRLYCKGADT----ILLDRLHHSTQE 595
            .|.  ..|....|::|.:|.|::.||.||::||. ...:|.||.||||:    :|:...|:|.:.
  Fly   906 LVSMPMAGATREYEILKVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEG 970

Human   596 LL-NTTMDHLNEYAGEGLRTLVLAYKDLDEEYYEEWAERRLQASLAQDSREDRLASIYEEVENNM 659
            :| ..|...|:.||.||||.||:|.:.|:...|.:|..|..:..::.::||.||...:.::|:|:
  Fly   971 ILREQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNL 1035

Human   660 MLLGATAIEDKLQQGVPETIALLTLANIKIWVLTGDKQETAVNIGYSCKMLTDDMTEVFIVTGHT 724
            .|||||.|||:||.|||||||.|..|.|.:|||||||.|||:||.||.|:.|..|
  Fly  1036 TLLGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQM---------- 1090

Human   725 VLEVREELRKAREKMMDSSRSVGNGFTYQDKLSSSKLTSVL----EAVAGEYALVINGHSLAHAL 785
                  ||.:...:..|::.:..|  .|...:.:.|.||.|    .....:.|||::|.:|...|
  Fly  1091 ------ELIRLTARSRDAAETAIN--FYLTDMENDKTTSTLGYGQSLRKKQRALVVDGKTLTFIL 1147

Human   786 E--ADMELEFLETACACKAVICCRVTPLQKAQVVELVKKYKKAVTLAIGDGANDVSMIKTAHIGV 848
            :  :.:.|.||..:..|.:|:|||.||||||.:|::||:.....||||||||||||||:.|.:||
  Fly  1148 DPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQMADVGV 1212

Human   849 GISGQEGIQAVLASDYSFSQFKFLQRLLLVHGRWSYLRMCKFLCYFFYKNFAFTMVHFWFGFFCG 913
            |||||||:|||:|:|::..:|::|:||||.||.|.|.|:.:.:.||||||.||..:.||:..:||
  Fly  1213 GISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCG 1277

Human   914 FSAQTVYDQYFITLYNIVYTSLPVLAMGVFDQDVPEQRSMEYPKLYEPGQLNLLFNKREFFICIA 978
            ||.|.:.||.::.|||:::||||.||:||:|:.|.|...::.|.||:.|:|.:.:...:|::.:.
  Fly  1278 FSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFWLILL 1342

Human   979 QGIYTSVLMFFIPYGVFADATRDDGTQLADYQSFAVTVATSLVIVVSVQIGLDTGYWTAINHFFI 1043
            ..:|.|:::||:....:|::  |.|     ...|..|:..|.:....|...::...||.::...|
  Fly  1343 DALYQSLVIFFVALCAYAES--DVG-----IWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSI 1400

Human  1044 WGSLAVY--FAILF---AMHSNGLFDMFPNQFRFVGNAQNTLAQPTVWLTIVLTTVVCIMPVVAF 1103
            ..||..:  |||::   .|:..|:...:...|....:|.:       ||.|:|:|||.::|.:..
  Fly  1401 VLSLGSFYLFAIVYDSVCMNCFGVRSSYWVIFVCFASAVH-------WLVIMLSTVVAVLPRLLL 1458

Human  1104 RFLRLNLKPDLSDTVRYTQLVRKKQKAQHR 1133
            ..:|::|.||.|     |:::.:.::.:.|
  Fly  1459 TTVRISLCPDDS-----TKVILQSKRERSR 1483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B2	NP_001354863.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		10/26 (38%)
ATP8B2	NP_001354863.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1181..1209
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	24/49 (49%)
		ATPase-Plipid	250..1473	CDD:273734	413/1269 (33%)
		E1-E2_ATPase	302..>394	CDD:278548	39/92 (42%)
		Cation_ATPase	<880..965	CDD:289987	32/84 (38%)
		HAD_like	<1177..1240	CDD:304363	37/62 (60%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	84/258 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830