Protein Alignment ATP10A and ATP8B

DIOPT Version :9

• Sequence 1: NP_077816.1
• Gene: ATP10A / 57194
• HGNCID: 13542
• Length: 1499
• Species: Homo sapiens
• Sequence 2: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Alignment Length: 1558
• Identity: 500/1558 - (32%)
• Similarity: 760/1558 - (48%)
• Gaps: 318/1558 - (20%)

Human     2 EREPAGT-EEPGPPGRRRRREGRTRTVRSNLLPPPGAEDPAAGAAKGERRRRRGCAQHLA----- 60
            :|:|:.| |....|..||..:.|.|  ||:..           .::.|||.|....:..|
  Fly   159 QRDPSVTSESKSVPSLRRLSQIRRR--RSSYY-----------FSENERRIRANDKEFNAQFKYH 210

Human    61 DNRLKTTKYTLLSFLPKNLFEQFHRPANVYFVFIALLNFVPAVNAFQPGLALAPVLFILAITAFR 125
            :|.:||:||:|.:|||.||.|||.|.||.||:.:.:|..:||:::..|.....|::.:|.:||.:
  Fly   211 NNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAVK 275

Human   126 DLWEDYSRHRSDHKINHLGCLVFSREEK-----KYVNRFWKEIHVGDFVRLRCNEIFPADILLLS 185
            |.::|..||.||.::|       :|:.|     |.|...|.|:.|||.:||..|:...||.||||
  Fly   276 DAYDDIQRHISDSQVN-------NRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLS 333

Human   186 SSDPDGLCHIETANLDGETNLKRRQVVRGFSELVSEFNPL-TFTSVIECEKPNNDLSRFRGCIIH 249
            :|:|:|||.||||.||||||||.:|.:....||....:.| .|...|.||:|||.|::|.|.:|.
  Fly   334 TSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIW 398

Human   250 DNGKKAGLYKENLLLRGCTLRNTDAVVGIVIYAGHETKALLNNSGPRYKRSKLERQMNCDVLWCV 314
             .|::..|..|.:|||||.||||....|:|::||.:||.:.|:...::|.:.::|.:|..::..|
  Fly   399 -RGQRFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIGIV 462

Human   315 LLLVCMSLFSAVGHGLWIWRYQEKKSLF-----YVPKSDGSSLSPVTAAVYS---FLTMIIVLQV 371
            |.||.:....|:|..:|.....:...|:     .:||    ...|..|.|..   |.:..|||..
  Fly   463 LFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPK----DYIPTGATVIGLLVFFSYAIVLNT 523

Human   372 LIPISLYVSIEIVKACQVYFINQDMQLYDEETDSQLQCRALNITEDLGQIQYIFSDKTGTLTENK 436
            ::|||||||:|:::..|.:.||.|.::|...|::..:.|...:.|:||||||||||||||||:|.
  Fly   524 VVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNI 588

Human   437 MVFRRCTVSGVEYSH--DANAQRLARYQEADSEEEEVVPRGGSVSQR-----GSI----GSHQSV 490
            |.|.:|:::|..|..  |.....|     .:..|::.:.:..:.:.|     |:|    .:...:
  Fly   589 MTFNKCSINGRSYGDVIDLRTGEL-----VEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPI 648

Human   491 RVVHRTQSTKSHRRTGSRAEAKRASMLSKHTAFSSPMEKDITPD-PKLLEKVSECDKSL------ 548
            .:||:.:           ..||:.||:     .:|..|..:.|| |:     |:.::|.
  Fly   649 ILVHKAE-----------VHAKKTSMV-----VTSSGEAQVLPDRPR-----SDIERSAPPMDAS 692

Human   549 ------------AVARHQEHLLAHLSPELSDVFDFFIALTICNTVVVTSPDQPRTKVRVRFELKS 601
                        |.:|.|:.....|||.|..                            ...|..
  Fly   693 EKRPGLKHVRYSAPSRSQDADAGRLSPRLDG----------------------------SGGLSP 729

Human   602 PV----KTIEDFLRRFTPSCL------TSGCSSIGSL--AANKSSHKLGSS-------------- 640
            ||    :.|....:|....|:      ||.|..:..|  :....:|.:..|
  Fly   730 PVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRLVKIRFKK 794

Human   641 FPSTPSSDGMLLRLEERLG---QPTSAIASNGY-----SSQADNWASE----------------- 680
            .|||.:...::.:||..|.   |.||.:::..:     .:.|.||:|.
  Fly   795 APSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDFSANPH 859

Human   681 ----------------LAQEQES------------------ERELRYEAESPDEAALVYAARAYN 711
                            .:.|:.|                  :.:|.|:|:||||||||.|||.:.
  Fly   860 HESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETVDGKLEYQAQSPDEAALVSAARNFG 924

Human   712 CVLVERLHDQVSVELPHLGRL-TFELLHTLGFDSVRKRMSVVIRHPLTDEINVYTKGADSVVMDL 775
            .|...|..:.:::|:  :|:. .:|||:.|.|::|||||||::|.  .|.:.:|.||||:|:.|.
  Fly   925 FVFRTRTPNSITIEV--MGQTEEYELLNILDFNNVRKRMSVILRR--GDSMVLYCKGADNVIYDR 985

Human   776 LQPCSSVDARGRH--QKKIRSKTQNYLNVYAAEGLRTLCIAKRVLSKEEYACWLQSHLEAESSLE 838
            |           |  |:.::::||::||.:|.||||||.:|:|.|:::.|..|.....||..|::
  Fly   986 L-----------HGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAALSMD 1039

Human   839 NSEELLFQSAIRLETNLHLLGATGIEDRLQDGVPETISKLRQAGLQIWVLTGDKQETAVNIAYAC 903
            :.|:.|......:|:.:.|:|.|.|||:||||||::|:.|:.||::||||||||||||:||.|:|
  Fly  1040 SREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGYSC 1104

Human   904 KLLDHD------------EEV-------------------------ITLNATS-QEACAALLDQC 930
            :||..:            |||                         ..||:.| .:..:..:.|.
  Fly  1105 QLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQT 1169

Human   931 LCYVQSRGLQRAP--------------EKTK----GKVSMRFSSLCPPSTSTASGRRPSLVID-- 975
            ..::|...|...|              ||.|    |..|...::|......:..|...|:|:|
  Fly  1170 SAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTASIVVDEN 1234

Human   976 --------GRSLAYALEKNLEDKFLFLAKQCRSVLCCRSTPLQKSMVVKLVRSKLKAMTLAIGDG 1032
                    |.||.:.|...||:|||.:|.||::|:|||.|||||::||:|::....|:|||||||
  Fly  1235 TGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVTLAIGDG 1299

Human  1033 ANDVSMIQVADVGVGISGQEGMQAVMASDFAVPKFRYLERLLILHGHWCYSRLANMVLYFFYKNT 1097
            |||||||:.|.:|||||||||:|||::||:::.:||||||||::||.|.|.|:...:.||||||.
  Fly  1300 ANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKNF 1364

Human  1098 MFVGLLFWFQFFCGFSASTMIDQWYLIFFNLLFSSLPPLVTGVLDRDVPANVLLTNPQLYKSGQN 1162
            .|.....|:..||||||.|:.|..::..:||.::|||.|..||.::||.....|..|:||..|..
  Fly  1365 AFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGLK 1429

Human  1163 MEEYRPRTFWFNMADAAFQSLVCFSIPYLAYYD---SN----VDLFTWGTPIVTIALLTFLLHLG 1220
            .|.:..|.|.:::...||.|||.|.|||..|.|   :|    .|..|.|..:.||.::.....:.
  Fly  1430 SELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMTLGAVVATILIVDNTAQIS 1494

Human  1221 IETKTWTWLNWITCGFSVLLFFTVALIYNASCATCYPPSNPY-WTMQALLGDPVFYLTCLMTPVA 1284
            :.|..||.:|.:|...|::.:|.:...||      |....|| .::...:.|..|::|.|:|.:|
  Fly  1495 LYTSYWTVVNHVTIWGSLVWYFVLDYFYN------YVIGGPYVGSLTQAMKDLTFWVTMLITVMA 1553

Human  1285 ALLPRLFFRSLQGRVFPTQLQLARQLTRKS--PRRCSAPKETFA--QGRLPKDSG--TEHSSG 1341
            .:.|.|.::.....|.|:.....||.:.|.  .|..|..:.|.:  :||....||  ..|..|
  Fly  1554 LVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHSRASSDVRRTASSRRGRRSVRSGYAFAHQEG 1616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP10A	NP_077816.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..53		14/51 (27%)
		PhoLip_ATPase_N	49..108	CDD:292826	26/63 (41%)
		ATPase-Plipid	61..1309	CDD:273734	472/1453 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	464..531		12/75 (16%)
		Cation_ATPase	<697..782	CDD:289987	37/85 (44%)
		HAD_like	<1026..1057	CDD:304363	25/30 (83%)
		PhoLip_ATPase_C	1057..1302	CDD:292829	88/252 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1311..1356		10/37 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1464..1499
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	26/64 (41%)
		Cation_ATPase	891..985	CDD:289987	38/97 (39%)
		HAD_like	<1261..1324	CDD:304363	41/62 (66%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	88/252 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830