DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP10A and CG31729

DIOPT Version :9

Sequence 1:	NP_077816.1	Gene:	ATP10A / 57194	HGNCID:	13542	Length:	1499	Species:	Homo sapiens
Sequence 2:	NP_609634.1	Gene:	CG31729 / 34736	FlyBaseID:	FBgn0051729	Length:	1256	Species:	Drosophila melanogaster

Alignment Length:	1301	Identity:	341/1301 - (26%)
Similarity:	550/1301 - (42%)	Gaps:	317/1301 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    18 RRREGRTRTVRSNLLPPPGAEDPAAGAAKGERRRRRGCAQHLADNRLKTTKYTLLSFLPKNLFEQ 82
            |.||.|.|||  ||           |....|:         ...|.::..||..::|||..||||
  Fly   209 RPRELRARTV--NL-----------GRVNTEK---------FPPNEIRNQKYNFITFLPLVLFEQ 251

Human    83 FHRPANVYFVFIALLNFVPAVNAFQPGLALAPVLFILAITAFRDLWEDYSRHRSDHKINHLGCLV 147
            |....|:||:.:||..|:|.:....|.....|:.|:|.:|..|:..:|..||:.||::|
  Fly   252 FRFFLNLYFLLMALSQFIPDIRIGYPYTYWGPLGFVLMVTICREAVDDLRRHQRDHEVN------ 310

Human   148 FSREEKK--------YVNRFWKEIHVGDFVRLRCNEIFPADILLLSSSDPDGLCHIETANLDGET 204
             |::.|:        |......::.|||.:.:..||..|||::||.:||..|...:.|..|||||
  Fly   311 -SQKYKRLSSTNISGYEMVPSSKLKVGDVIIVEKNERVPADLILLRTSDRSGSVFVRTDQLDGET 374

Human   205 NLKRRQVVRGFSELVSEFNPLTFTSVIECEKPNNDLSRFRG--CIIHDNGKKAGLYKENLLLRGC 267
            :.|.|..|....:|..:....:..:....|||.||:..|..  |:. |..:..||..||.|...
  Fly   375 DWKPRLAVPYTQKLSRDSELHSIDASFYVEKPQNDIHSFIATFCMA-DGSEDTGLSVENTLWAN- 437

Human   268 TLRNTDAVVGIVIYAGHETKALLNNSGPRYKRSKLERQMN--CDVLWCVLLLVCMSLFSAVGHGL 330
            |:.......|||||.|.||::::|||.||.|...|:.::|  ..||:|.:|.:.:.:....|.|.
  Fly   438 TVVAAGTATGIVIYTGCETRSVMNNSQPRSKVGLLDMEINGLTKVLFCAVLGLSLVMMMLKGFGG 502

Human   331 WIWRYQEKKSLFYVPKSDGSSLSPVTAAVYSFLTMIIVLQVLIPISLYVSIEIVKACQVYFINQD 395
            ..:||                       ::.|   :::...:|||||.|::::.||    |.:..
  Fly   503 PWYRY-----------------------MFRF---VLLFSYIIPISLRVNLDMGKA----FYSWQ 537

Human   396 MQLYDEETDSQLQ---CRALNITEDLGQIQYIFSDKTGTLTENKMVFRRCTVSGVEYSHDANAQR 457
            ||     .||.:|   .|:..|.|:||:|.|:.:|||||||:|:|||::..:..|  ||||:.
  Fly   538 MQ-----NDSNIQGTVVRSTTIPEELGRISYVLTDKTGTLTQNEMVFKKIHLGIV--SHDADT-- 593

Human   458 LARYQEADSEEEEVVPRGGSVSQRGSIGSHQSVRVVHRTQSTKSHRRTGSRAEAKRASMLSKHTA 522
                                        .|...:::.:.......::.||.:.:......:|...
  Fly   594 ----------------------------FHHIGQMIQKLSGNILQQQQGSLSSSSSGGDSTKPMM 630

Human   523 FSSPMEKDITPDPKLLEKVSECDKSLAVARHQEHLLAHLSPELSDVFDFFIALTICNTVVVTSPD 587
            |.:.|.:                                 ||....::...||.:|:.|...|.|
  Fly   631 FGNRMRR---------------------------------PEGWREWEAVRALALCHNVTPVSDD 662

Human   588 QPRTKVRVRFELKSPVKTIEDFLRRFTPSCLTSGCSSIGSLAANKSSHKLGSSFPSTPSSDGMLL 652
            :....|.                   |.|.:|.|.:|
  Fly   663 EDNRSVS-------------------TASTVTGGNNS---------------------------- 680

Human   653 RLEERLGQPTSAIASNGYSSQADNWASELAQEQESERELRYEAESPDEAALVYAARAYNCVLVER 717
                    ||.::.:             :.....::.|.:|:|.||||.|||.........|:.|
  Fly   681 --------PTKSVIN-------------IEAPGSTDTEHQYQAASPDEIALVKWTEQVGLTLIAR 724

Human   718 LHDQVSVELPHLGR-----LTFELLHTLGFDSVRKRMSVVIRHPLTDEINVYTKGADSVVMDLLQ 777
            ..:.:::::.....     |.:::|....|.|..|||.:::|...|.:|..|.||||.|:..::|
  Fly   725 DLNTMTLQVKTPSEDNDILLHYQILQLFPFTSESKRMGIIVRESKTGQITFYLKGADVVMSSIVQ 789

Human   778 PCSSVDARGRHQKKIRSKTQNYLNVYAAEGLRTLCIAKRVLSKEEYACWLQSHLEAESSLENSEE 842
                      :...:..::.|    .|.||||||.:||:||::|:|:.:...:..|..|:.:...
  Fly   790 ----------YNDWLSEESGN----MAREGLRTLVVAKKVLTEEQYSDFETRYNAARLSITDRVA 840

Human   843 LLFQSAIRLETNLHLLGATGIEDRLQDGVPETISKLRQAGLQIWVLTGDKQETAVNIAYACKLLD 907
            .:......||..|.||..||:|||||:.|..|:..||.||:::|:|||||.|||..||.:.:|:.
  Fly   841 KVAAVTESLERELELLCLTGVEDRLQENVRPTLELLRNAGVRVWMLTGDKLETACCIAKSSQLIG 905

Human   908 HDEEVITLNATSQEACAALLDQCLCYVQSRGLQRAPEKTKGKVSMRFSSLCPPSTSTASGRRP-- 970
            .::.:..|.:.                          ||:.......:|.          ||.
  Fly   906 RNQGLHVLRSV--------------------------KTRTDAHQELNSF----------RRKQG 934

Human   971 -SLVIDGRSLAYALEKNLEDKFLFLAKQCRSVLCCRSTPLQKSMVVKLVRSKLKAMTLAIGDGAN 1034
             :|||.|.||...|: ....:||.||....:|:|||.:|.||:.||.|::......|.|:|||.|
  Fly   935 HALVISGESLEVCLQ-YYRPEFLELATASPAVVCCRCSPTQKAQVVALIQKHTGKRTCAVGDGGN 998

Human  1035 DVSMIQVADVGVGISGQEGMQAVMASDFAVPKFRYLERLLILHGHWCYSRLANMVLYFFYKNTMF 1099
            ||||||.||.||||.|:||.||.:|.||::|:|.::.:||::||...|.|.|.:..:..::..:.
  Fly   999 DVSMIQQADAGVGIEGREGRQASLAGDFSIPQFSHIAKLLLIHGRRSYKRSAALSQFVIHRGLII 1063

Human  1100 VGLLFWFQFFCGFSASTMIDQWYLIFFNLLFSSLPPLVTGVLDRDVPANVLLTNPQLYKSGQNME 1164
            ..|...|......|:..:...:.::.::.|::.. |:.:.|||:|:.:...:|.|:|||......
  Fly  1064 TTLQAVFSAVFYLSSVALYQGFLMVGYSTLYTMF-PVFSLVLDQDITSETAVTYPELYKDLSKGR 1127

Human  1165 EYRPRTFWFNMADAAFQSLVCFSIPYLAYYDSNVDLFTWGTPIVTIA----LLTFLLHLGIETKT 1225
            ....:||:..:..:.:|..|......:.:.|..:.       ||.|:    ::|.|:.:.:..:|
  Fly  1128 SLSYKTFFIWVLISIYQGGVIMYGALILFVDEFIH-------IVAISFSALIMTELIMVALTVRT 1185

Human  1226 WTWLNWITCGFSVLLF----------------------FTVALIYNASC----------ATCYPP 1258
            |..|..:...||:.|:                      :.|:||...||          ..|.||
  Fly  1186 WHRLMVLAELFSLALYLISLAVLHEYFDWEFIWSYDFLWKVSLITLVSCLPLYIIKFLRKKCSPP 1250

Human  1259 S 1259
            |
  Fly  1251 S 1251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP10A	NP_077816.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		11/34 (32%)
		PhoLip_ATPase_N	49..108	CDD:292826	18/58 (31%)
		ATPase-Plipid	61..1309	CDD:273734	330/1258 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..531		6/66 (9%)
		Cation_ATPase	<697..782	CDD:289987	26/89 (29%)
		HAD_like	<1026..1057	CDD:304363	22/30 (73%)
		PhoLip_ATPase_C	1057..1302	CDD:292829	51/239 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1311..1356
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1464..1499
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826	19/60 (32%)
		ATPase-Plipid	228..1252	CDD:273734	330/1260 (26%)
		E1-E2_ATPase	323..525	CDD:278548	68/229 (30%)
		Cation_ATPase	<704..783	CDD:289987	24/78 (31%)
		HAD_like	<975..1019	CDD:304363	25/43 (58%)
		PhoLip_ATPase_C	1021..1249	CDD:292829	48/235 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144902
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860