DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP10A and CG4301

DIOPT Version :9

Sequence 1:	NP_077816.1	Gene:	ATP10A / 57194	HGNCID:	13542	Length:	1499	Species:	Homo sapiens
Sequence 2:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster

Alignment Length:	1379	Identity:	435/1379 - (31%)
Similarity:	666/1379 - (48%)	Gaps:	261/1379 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    48 ERRRRRGCAQHLADNRLKTTKYTLLSFLPKNLFEQFHRPANVYFVFIALLNFVPAVNAFQPGLAL 112
            :::|.:|      .||:|:|||||::|||:||.|||.|.||.||:.:.:::.: ..:...|..:|
  Fly    66 KKKRPKG------QNRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLL-IDSPVSPMTSL 123

Human   113 APVLFILAITAFRDLWEDYSRHRSDHKINHLGCLVFSREEKKYVNRFWKEIHVGDFVRLRCNEIF 177
            .|::|::|:||.:..:||..|:|:|:.:|.....|. |:.|:.:.:. :::..|:.:.:..:...
  Fly   124 LPLVFVIAVTAAKQGYEDILRYRTDNVVNSSPVTVI-RDGKEAIIKS-QDVIPGELIVVERDCDV 186

Human   178 PADILLLSSSDPDGLCHIETANLDGETNLKRRQVVRGFSEL-VSEFNPLTFTSVIECEKPNNDLS 241
            |.|::||.|:||.|.|.|.|||||||:|||...|.|....: :.|.:.|   .:||||.|..||.
  Fly   187 PCDLVLLRSTDPHGKCFITTANLDGESNLKTLMVPRDLPTVDLPEMHKL---GIIECESPTTDLY 248

Human   242 RFRGCI--IHDNGKKAGLYKENLLLRGCTLRNTDAVVGIVIYAGHETKALLNNSGPRYKRSKLER 304
            .|.|.|  ....|:...|..||:||||..::||:.|:|..:|.|..:|..||:...|.|.:..|.
  Fly   249 SFNGKIELKGGEGRVLPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSET 313

Human   305 QMNCDVLWCVLLLVCMSLFSAVGHGLWIWRYQEKKSLFYVPK----SDGSSLSPVTAAVYSFLTM 365
            .:|     ..|:::.::|.:.|....::.||.|   ||.:||    .|.:....|...:..:|:.
  Fly   314 YIN-----RFLIVILVALIAIVTLLYFLKRYNE---LFVIPKLTYLGDATDSYSVKQFLQDYLSF 370

Human   366 IIVLQVLIPISLYVSIEIVKACQVYFINQDMQLYDEETDSQLQCRALNITEDLGQIQYIFSDKTG 430
            :|:...||||||||:||:.:....:|:..|::||:.|||........|:.|:||||..:||||||
  Fly   371 LILFNYLIPISLYVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTG 435

Human   431 TLTENKMVFRRCTVSGVEYSHDANAQRLARYQEADSEEEEVVP----RGGSVSQRGSIGSHQSVR 491
            |||:|:|.|::|:::|.::          .:::...|:||...    ...|.:||...   |::.
  Fly   436 TLTKNEMNFQQCSINGNKF----------LFKKTRLEDEETKALLDINKFSANQRVFF---QALS 487

Human   492 VVHRTQSTKSHRRTGSRAEAKRASMLSKHTAF-SSPME----KDITPDPKLLEKVSE-------- 543
            :.|..|.............|||..:    ||. |.|.|    .|||.:.....:.||
  Fly   488 ICHTVQVASGSLEQADAGTAKREPV----TAIKSGPPEMYSISDITEESHNASQQSELNVGHTID 548

Human   544 ------------------------CDKSLAVARHQEHLLAHLSPELS--------DVFDFFIALT 576
                                    .|....|.|.:..::...||..:        ...|..|..|
  Fly   549 NSVSAHPNGVNSTIISSDVNPLLVSDDGYGVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQT 613

Human   577 ICNTVVVTSPDQPRTKVR---VRFELKSPVKTIEDFLRRFTPSCLTSGCSSIGSLAANKSSHKLG 638
            ..||  ||:..:|.|..|   ::|...:..|.::....  .||         |....::.:|..|
  Fly   614 DPNT--VTNGVEPTTNFRPISLQFRRSTSEKDLQQSWE--APS---------GQAPGHRRAHSYG 665

Human   639 SS--------FPSTPSSDGMLLRLEERLG-----------QPTSAIASNGYSSQADNWASELAQE 684
            :.        ..|||.: |:|.|......           |||..:.               |:.
  Fly   666 APNAYLTNPVTASTPPA-GVLFRSPSTTSRESYAAPTFTRQPTILVR---------------AES 714

Human   685 QESERELR-------YEAESPDEAALVYAARAYNCVLV----ERLHDQVSVELPHLG-------- 730
            |..:.|:|       |:|.||||.|||.|......|..    |.|  :|.:..||:.
  Fly   715 QRRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDETL--RVRIVPPHMDYKRPFAKP 777

Human   731 -RLTFELLHTLGFDSVRKRMSVVIRHPLTDEIN-VYTKGADSVVMDLLQPCSSVDARGRHQKKIR 793
             ..||:.||.|.|.|.||||||::|.  ||... :|||||:|.|..|   |::..|      ::.
  Fly   778 REETFQRLHVLEFTSDRKRMSVIVRD--TDGKKWIYTKGAESYVFPL---CANSSA------ELV 831

Human   794 SKTQNYLNVYAAEGLRTLCIAKRVLSKEEYACWLQSHLEAESSLENSEELLFQSAIRLETNLHLL 858
            :||..:::.:|..|||||.||:|::|:|||..:|....:|.|||||.::|..:...::|:||.||
  Fly   832 TKTDAHISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEECYAKIESNLDLL 896

Human   859 GATGIEDRLQDGVPETISKLRQAGLQIWVLTGDKQETAVNIAYAC-------------KLLDHDE 910
            |||.:||.|||.|.:|:..|:.||::||||||||.|||:|||.:|             :..:.:|
  Fly   897 GATAVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAKKYFIMECKNREE 961

Human   911 EVITLNATSQEACAALLDQCLCYVQSRGLQRAPEKTKGKVSMRFSSLCPPSTSTASGRRPSLVID 975
            .::.|||..:|....:..:|                                        :|:||
  Fly   962 MLLHLNALDREIIFGIGQEC----------------------------------------ALLID 986

Human   976 GRSLAYALEKNLEDKFLFLAKQCRSVLCCRSTPLQKSMVVKLVRSKLKAM-TLAIGDGANDVSMI 1039
            |:||..||.: ...:|..:|.:|.:|||||.:|||||.||.|::|..:.. |.:|||||||||||
  Fly   987 GKSLGVALAE-ASSEFRDVAVKCTAVLCCRLSPLQKSEVVSLIKSSNENYNTASIGDGANDVSMI 1050

Human  1040 QVADVGVGISGQEGMQAVMASDFAVPKFRYLERLLILHGHWCYSRLANMVLYFFYKNTMFVGLLF 1104
            |.|.||:||.|:||.||...:|||..||..|:|||::|||:...||:.:||||||||.:|:|::|
  Fly  1051 QEAHVGIGIMGREGRQAARCADFAFAKFCMLKRLLLVHGHYHSVRLSLLVLYFFYKNIVFMGIMF 1115

Human  1105 WFQFFCGFSASTMIDQWYLIFFNLLFSSLPPLVTGVLDRDVPANVLLTNPQLYKSGQNMEEYRPR 1169
            .|||...||:|::.|..:|..:|::::|||.|...:.::......|:..|||||...:.::....
  Fly  1116 LFQFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAISEKPYTEEKLMRTPQLYKKNTDNKQLHWP 1180

Human  1170 TFWFNMADAAFQSLVCFSIPYLAYYDSNVDLFTWGTPIVTIALLTFLLHLGIETKTWT------- 1227
            .|...:..|.:.|::.|...:..:|.:|| |..:|..:......|.|:        ||
  Fly  1181 YFLMWVLFAIYHSVIIFYFAFCFFYYNNV-LLNYGQTVAFSCFGTLLM--------WTVVVVVNL 1236

Human  1228 --WLN------W--ITCGFSVLLFFTVALIYNASCATCYPPSNPYWTMQALLGDPVFYLTCLMTP 1282
              ||.      |  .|...|:|.|....:|||.  ......::.||....||.....:|..::|.
  Fly  1237 KLWLESMYLSFWYIFTIIISILGFVVTTVIYNV--INLDYDTDIYWAYNNLLASLPVWLWIIVTC 1299

Human  1283 VAALLPRLFFRSLQ 1296
            ||.|:|....|.||
  Fly  1300 VACLVPDYTIRMLQ 1313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP10A	NP_077816.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		1/4 (25%)
		PhoLip_ATPase_N	49..108	CDD:292826	23/58 (40%)
		ATPase-Plipid	61..1309	CDD:273734	433/1366 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..531		17/75 (23%)
		Cation_ATPase	<697..782	CDD:289987	39/98 (40%)
		HAD_like	<1026..1057	CDD:304363	22/30 (73%)
		PhoLip_ATPase_C	1057..1302	CDD:292829	80/257 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1311..1356
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1464..1499
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	24/61 (39%)
		ATPase-Plipid	74..1317	CDD:273734	433/1365 (32%)
		E1-E2_ATPase	127..>345	CDD:278548	77/230 (33%)
		Cation_ATPase	<734..823	CDD:289987	38/95 (40%)
		HAD_like	<1036..1066	CDD:304363	21/29 (72%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	80/257 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102565
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720