DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP10A and CG9981

DIOPT Version :9

Sequence 1:	NP_077816.1	Gene:	ATP10A / 57194	HGNCID:	13542	Length:	1499	Species:	Homo sapiens
Sequence 2:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster

Alignment Length:	1279	Identity:	373/1279 - (29%)
Similarity:	576/1279 - (45%)	Gaps:	278/1279 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    62 NRLKTTKYTLLSFLPKNLFEQFHRPANVYFVFIALLNFVPAVN-AFQPGLALAPVLFILAITAFR 125
            ||:.|||||..:|||.|.:|||.|....||:.|.:::|.  || ...|.::|.|:||::.|||.:
  Fly    28 NRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFF--VNETISPLVSLLPLLFVMIITALK 90

Human   126 DLWEDYSRHRSDHKINHLGCLVFSREEKKYVNRFWKEIHVGDFVRLRCNEIFPADILLLSSSDPD 190
            :..|||||.:||..:|.....|....:::.:|.  :.|..||.|.:|.:...|.|::||.||..|
  Fly    91 EGLEDYSRSKSDKLVNTARVTVIRNGKEEIINS--QFIVPGDLVVVRNDGDVPCDLVLLQSSSAD 153

Human   191 GLCHIETANLDGETNLKRRQVVRGFSELVSEFNPLTFTSVIECEKPNNDLSRFRGCII----HDN 251
            ..|.:.|||||||||||...|...:  |::..:.|.....|.||..:.||..|.|.:.    :|.
  Fly   154 RKCFVNTANLDGETNLKTICVPTNY--LLAGDHELQGKDCIVCEPSSADLYTFNGRLELRSGNDG 216

Human   252 -GKKAG----LYKENLLLRGCTLRNTDAVVGIVIYAGHETKALLNNSGPRYKRSKLERQMNCDVL 311
             |..||    |..:||||||..:::|:.|||..||.|..||..||:.....|.:..|:.:|   .
  Fly   217 AGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASSEKYIN---R 278

Human   312 WCVLLLVCMSLFSAVGHGLWIWRYQEKKSLFYVP-KSDGSSLSPVTAAVYSFLTMIIVLQVLIPI 375
            :.|.|:|.|.:...|.:  .|.|::|.|.:..:| :...::.:........||:.:::...::||
  Fly   279 FMVALIVGMIVVVVVLY--LIERHKEAKIVPTMPYQGPPTNFNSAWQIFEDFLSFLLLFNYMVPI 341

Human   376 SLYVSIEIVKACQVYFINQDMQLYDEETDSQLQCRALNITEDLGQIQYIFSDKTGTLTENKMVFR 440
            |.|::||:.:...::|::.|:.|||||||...:..|.|:.|:|||:..:|||||||||:|.|.|.
  Fly   342 SAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFSDKTGTLTKNLMKFV 406

Human   441 RCTVSGVEYSHDANAQRLARYQEADSEEEEVVPRGGSVSQRGSIGSHQSVRVVHRTQSTKSHRRT 505
            .|.|.|..|                                               |...:|
  Fly   407 NCYVPGTNY-----------------------------------------------QLQNTH--- 421

Human   506 GSRAEAKRASMLSKHTAFSSPMEKDITPDPKL-LEKVSECDKSLAVARHQEHLLAHLSPELSDVF 569
                      ::|:.|            |.|. |||:   |...||
  Fly   422 ----------LVSEGT------------DEKFELEKL---DADAAV------------------- 442

Human   570 DFFIALTICNTVVVTSPDQPRTKVRVRFELKSPV--KTIEDFLRRFTPSCLTSGCSSIGSLAANK 632
             .|.||.:|:||                |:...|  ||:|                  .|.:.::
  Fly   443 -LFEALAVCHTV----------------EVLQEVGDKTLE------------------SSESVSE 472

Human   633 SSHKLGSSFPSTPSSDGMLLRLEERLGQPTSAIASNGYSSQADNWASELAQEQESERELRYEAES 697
            .||.:..:...                                                ||:|.|
  Fly   473 QSHLMSRNIVD------------------------------------------------RYQASS 489

Human   698 PDEAALVYAARAYNCVLVERLHDQVSV-ELPHLGRLTFELLHTLGFDSVRKRMSVVIRHPLTDEI 761
            |||.||:....:...|...:.:|.:|: ..|...::.|:.||.|.|.|.|:||||::|.. :|.|
  Fly   490 PDEKALLEGCASLGLVYEGQENDVLSICRYPSAEKVQFKRLHVLEFSSERQRMSVIVRDQ-SDTI 553

Human   762 NVYTKGADSVVMDLLQPCSSVDARGRHQKKIRSKTQNYLNVYAAEGLRTLCIAKRVLSKEEYACW 826
            .:|:|||:|.:....:....|:           :|...:..||..||||:.:.:|:|:.:|...:
  Fly   554 WLYSKGAESAIFPRCKASPLVE-----------QTDAQITKYAQNGLRTMAVGRRMLTDDELFHF 607

Human   827 LQSHLEAESSLENSEELLFQSAIRLETNLHLLGATGIEDRLQDGVPETISKLRQAGLQIWVLTGD 891
            .:.:.:|.:.|.|..||:......:|..|.|||||.:||.||:.|.||:..|:.|||:|||||||
  Fly   608 EELYRKANTQLSNRNELIASCYETVENELDLLGATALEDALQEHVGETLEALQAAGLKIWVLTGD 672

Human   892 KQETAVNIAYACKLLDH-DEEVITLNATSQEACAALLDQCLCYVQSRGLQRAPEKTKGKVSMRFS 955
            |.|||.||..||:.:.. .::...:|.|......|.||.
  Fly   673 KVETAYNIGLACRHIPRGSKQHFIINTTEPAELLARLDM-------------------------- 711

Human   956 SLCPPSTSTASGRRPSLVIDGRSLAYALEKNLEDKFLFLAKQCRSVLCCRSTPLQKSMVVKLVRS 1020
                    ........|::||.::. ||.::...:|..||.:||:|||||.:|||||.:|.|::.
  Fly   712 --------IGDDEPEVLIVDGTTIT-ALLEHTPRQFADLALRCRAVLCCRLSPLQKSEIVTLIKR 767

Human  1021 KLKAMTLAIGDGANDVSMIQVADVGVGISGQEGMQAVMASDFAVPKFRYLERLLILHGHWCYSRL 1085
            :.|.:|.|||||||||||||.|.:|:||:|:||.||...:||::.:|..|.||.::|||:...||
  Fly   768 RKKYITAAIGDGANDVSMIQEAHIGIGITGREGKQAARCADFSIARFEMLRRLFLVHGHYNSQRL 832

Human  1086 ANMVLYFFYKNTMFVGLLFWFQFFCGFSASTMIDQWYLIFFNLLFSSLPPLVTGVLDRDVPANVL 1150
            |.:||::.|||.:..|.:..:|.:..:||:.:.:..||..|::::.|....|..:.|:|.....|
  Fly   833 AFLVLFYCYKNIIITGCMALYQVYDLYSATNVYNSIYLWLFDIVYISFSFTVLAICDKDYSEETL 897

Human  1151 LTNPQLYKSGQNMEEYRPRTFWFNMADAAFQSLVCFSIPYLAYYDSNVDLF---------TWGTP 1206
            |::|:|||...:..:.....|...:.:...|..:.|...|....|:|| ||         |:||.
  Fly   898 LSHPELYKPLAHNRQASMGVFSLWILNGFVQCFIIFFFTYAMLNDANV-LFNGGQTASFQTFGTM 961

Human  1207 IVTIALLTFLLHLGIETKTWTWLNWITCGFSVLLFFTVALIYNASCATCYPPSNPYWTMQALLGD 1271
            ::||.::...|.|.:.....|:.|:.....|:..|.....:||     .|.....|......|..
  Fly   962 LITIIVIVGNLKLLLVAHYMTYRNFAMILASIAAFMLTTYLYN-----LYTSGELYDVYNQFLSS 1021

Human  1272 PVFYLTCLMTPVAALLPRLFFRSLQGRVFPTQLQLARQLTRKSP 1315
            ...:|..::..||.|||...            :::...:.||.|
  Fly  1022 LPIWLFTIICSVACLLPDFV------------IKVVNDMYRKVP 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP10A	NP_077816.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53
		PhoLip_ATPase_N	49..108	CDD:292826	21/46 (46%)
		ATPase-Plipid	61..1309	CDD:273734	370/1271 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..531		4/66 (6%)
		Cation_ATPase	<697..782	CDD:289987	29/85 (34%)
		HAD_like	<1026..1057	CDD:304363	22/30 (73%)
		PhoLip_ATPase_C	1057..1302	CDD:292829	65/253 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1311..1356		3/5 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1464..1499
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	18/37 (49%)
		ATPase-Plipid	28..1051	CDD:273734	370/1275 (29%)
		E1-E2_ATPase	84..>189	CDD:278548	40/108 (37%)
		Cation_ATPase	<489..568	CDD:289987	29/79 (37%)
		HAD_like	<758..807	CDD:304363	28/48 (58%)
		PhoLip_ATPase_C	804..1050	CDD:292829	65/263 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820