DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP10A and CG33298

DIOPT Version :9

Sequence 1:	NP_077816.1	Gene:	ATP10A / 57194	HGNCID:	13542	Length:	1499	Species:	Homo sapiens
Sequence 2:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster

Alignment Length:	1493	Identity:	579/1493 - (38%)
Similarity:	817/1493 - (54%)	Gaps:	265/1493 - (17%)

- Green bases have known domain annotations that are detailed below.

Human     8 TEEP----GPPGRRRRREGRTRTVRSNLLPPPGAEDPA--------AGAAKGERRR--------- 51
            |:.|    .|.||...|.| ::|  ..:|||...|:||        |...:|..|:
  Fly   137 TDSPPGSAAPAGRGHSRVG-SKT--DFILPPGHKEEPAREPSAPTSATGGRGHSRQASRSESIYT 198

Human    52 -RRG-----------CAQHLAD--------------------------------NRLKTTKYTLL 72
             ||.           |..:..|                                |:::|||||||
  Fly   199 LRRTEAPPWWKRLTLCNYNTGDKFEERSYRTVVPNHTVPPKTPKRDHPNGQFVGNKIRTTKYTLL 263

Human    73 SFLPKNLFEQFHRPANVYFVFIALLNFVPAVNAFQPGLALAPVLFILAITAFRDLWEDYSRHRSD 137
            ||:||||.|||||.||:||:||.|||:||.::||...:|:.||||:|.:||.:||:||..|..||
  Fly   264 SFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASD 328

Human   138 HKINHLGCLVFSREEKKYVNRFWKEIHVGDFVRLRCNEIFPADILLLSSSDPDGLCHIETANLDG 202
            .:||:..|.|:..|.::|....|:|:.|||.|.|..||..|||||||.:|||.|:|:|:|.:|||
  Fly   329 KRINNTTCRVYDGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDG 393

Human   203 ETNLKRRQVVRGFSELVSEFNPLTFTSVIECEKPNNDLSRFRGCIIHDNGKKAGLYKENLLLRGC 267
            |||||||:|||||.|:.|.|.|..|.|.:|.:.|...|.||.|.:||..|::..:..|.||||..
  Fly   394 ETNLKRREVVRGFEEMQSIFVPSKFVSRVEADAPTTKLYRFHGALIHPTGERVPISTECLLLRES 458

Human   268 TLRNTDAVVGIVIYAGHETKALLNNSGPRYKRSKLERQMNCDVLWCVLLLVCMSLFSAVGHGLWI 332
            .|:|||.:.|||:|||||||::|||||||||||::|:|||.||:|||::|:.:.:..|:|..:|:
  Fly   459 RLKNTDYIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWL 523

Human   333 WRYQEKKSLFYVPKSDGSSLSPVTAAVYSFLTMIIVLQVLIPISLYVSIEIVKACQVYFINQDMQ 397
            ..:..    |.||....:.|:....:::.|.|.|::|||:||:||||:||:.|..||:.|:.::.
  Fly   524 SSFTH----FPVPYLPPNKLTANMESMWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVD 584

Human   398 LYDEETDSQLQCRALNITEDLGQIQYIFSDKTGTLTENKMVFRRCTVSGVEYSHDANAQRLARYQ 462
            |:|.||:.|.:|||:||||:|||||:||:|||||||||||:||||.|:|.:|:|
  Fly   585 LFDAETNKQTECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNH----------- 638

Human   463 EADSEEEEVVPRGGSVSQRGSIGSHQSVRVVHRTQSTKSHRRTGSRAEAKRASMLSKHTAFSSPM 527
             ..||.|::..:.|:.:
  Fly   639 -PPSELEKIYSKPGAPA------------------------------------------------ 654

Human   528 EKDITPDPKLLEKVSECDKSLAVARHQEHLLAHLSPELSDVFDFFIALTICNTVVV-TSPDQPRT 591
             ..:.|:..|...:::..:.           .:|:|....:.:|.:.|.|||||:| .:|.:...
  Fly   655 -PPLIPNDNLNSDMAQLTQG-----------TYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDMM 707

Human   592 KVRVRFELK----SPV---------KTIEDFLRRFTPSCLTSGCSS---IGSLAANKSSHKLGSS 640
            ......|::    ||.         |.:.......|.:.:.:|.::   :.|:.|::.. :|..|
  Fly   708 NASGIIEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYI-RLAES 771

Human   641 FPSTPS-SDGMLLRLEERLGQPT-SAIASNGYSSQADNWASELAQEQESERELR----------- 692
            ...||| ...:|..|..:..||| |.|:|:..||  .|..||........:.|.
  Fly   772 RSVTPSPPPNLLFALPAQSHQPTLSPISSSAESS--PNSESESPSPPMKNKSLSNSISPTGRAKA 834

Human   693 -----------------------------------------YEAESPDEAALVYAARAYNCVLVE 716
                                                     ||||||||.|||.||.:|:|.|:.
  Fly   835 VINSKITSIATFLNAKTQGKRMKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLN 899

Human   717 RLHDQVSVELPHLGRL-TFELLHTLGFDSVRKRMSVVIRHPLTDEINVYTKGADSVVMDLLQPCS 780
            |..:|:.|.:|..|.. .:|:|..|.|||.||.||:|:|...:.||.:|||||||.:|.:|.|||
  Fly   900 RSPNQILVSMPMAGATREYEILKVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCS 964

Human   781 SVDARGRHQKKIRSKTQNYLNVYAAEGLRTLCIAKRVLSKEEYACWLQSHLEAESSLENSEELLF 845
            .....|    .:|.:||..|:.||.||||.|.:|||.|:..:|..|...|.|.|.||||.|..|.
  Fly   965 HNSPEG----ILREQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLR 1025

Human   846 QSAIRLETNLHLLGATGIEDRLQDGVPETISKLRQAGLQIWVLTGDKQETAVNIAYACKLLDHDE 910
            .|..:||:||.|||||||||||||||||||:.|..||:.:|||||||.|||:||||:.||.....
  Fly  1026 DSFAKLESNLTLLGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQM 1090

Human   911 EVITLNATSQEACAALLDQCLCYVQSRGLQRAPEKTKGKVSMRFSSLCPPSTSTAS------GRR 969
            |:|.|.|.|::|....::..|..:::       :||               |||..      .::
  Fly  1091 ELIRLTARSRDAAETAINFYLTDMEN-------DKT---------------TSTLGYGQSLRKKQ 1133

Human   970 PSLVIDGRSLAYALE--KNLEDKFLFLAKQCRSVLCCRSTPLQKSMVVKLVRSKLKAMTLAIGDG 1032
            .:||:||::|.:.|:  ..|...||.|:|:|.||||||||||||:.:||:|:.:|...|||||||
  Fly  1134 RALVVDGKTLTFILDPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDG 1198

Human  1033 ANDVSMIQVADVGVGISGQEGMQAVMASDFAVPKFRYLERLLILHGHWCYSRLANMVLYFFYKNT 1097
            ||||||||:||||||||||||||||||:||.:|:||||||||:.||:|||.||:.|:|||||||.
  Fly  1199 ANDVSMIQMADVGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNA 1263

Human  1098 MFVGLLFWFQFFCGFSASTMIDQWYLIFFNLLFSSLPPLVTGVLDRDVPANVLLTNPQLYKSGQN 1162
            .||.|:||:|.:||||...|:||.||:.:||:|:|||||..||.|:.|..::||.||.|||:|:.
  Fly  1264 AFVFLIFWYQLYCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRL 1328

Human  1163 MEEYRPRTFWFNMADAAFQSLVCFSIPYLAYYDSNVDLFTWGTPIVTIALLTFLLHLGIETKTWT 1227
            ...|||..||..:.||.:||||.|.:...||.:|:|.::.:||.|....|...|:|..||.::||
  Fly  1329 GVAYRPHDFWLILLDALYQSLVIFFVALCAYAESDVGIWEFGTTITASCLFANLVHCAIEIRSWT 1393

Human  1228 WLNWITCGFSVLLFFTVALIYNASCATCYPPSNPYWTMQALLGDPVFYLTCLMTPVAALLPRLFF 1292
            .|:.::...|:..|:..|::|::.|..|:...:.||.:.......|.:|..:::.|.|:||||..
  Fly  1394 VLHVLSIVLSLGSFYLFAIVYDSVCMNCFGVRSSYWVIFVCFASAVHWLVIMLSTVVAVLPRLLL 1458

Human  1293 RSLQGRVFPTQ-----LQLARQLTRKSPRRCSAPKETFAQG--RLPKDSGTEHSSGRTVKTSV 1348
            .:::..:.|..     ||..|:.:|......:..:.|.|..  |:     |::.|...:.|::
  Fly  1459 TTVRISLCPDDSTKVILQSKRERSRGEALLVTWSRSTSASSIYRI-----TDYGSKNQIITTI 1516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP10A	NP_077816.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		17/66 (26%)
		PhoLip_ATPase_N	49..108	CDD:292826	37/111 (33%)
		ATPase-Plipid	61..1309	CDD:273734	551/1364 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..531		4/66 (6%)
		Cation_ATPase	<697..782	CDD:289987	43/85 (51%)
		HAD_like	<1026..1057	CDD:304363	29/30 (97%)
		PhoLip_ATPase_C	1057..1302	CDD:292829	107/244 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1311..1356		7/40 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1464..1499
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	32/49 (65%)
		ATPase-Plipid	250..1473	CDD:273734	548/1327 (41%)
		E1-E2_ATPase	302..>394	CDD:278548	46/91 (51%)
		Cation_ATPase	<880..965	CDD:289987	42/84 (50%)
		HAD_like	<1177..1240	CDD:304363	47/62 (76%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	107/244 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	395	1.000	Domainoid score	I762
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	971	1.000	Inparanoid score	I319
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D37083at33208
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	1	1.000	-	-		otm42056
orthoMCL	1	0.900	-	-		OOG6_102565
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3512
SonicParanoid	1	1.000	-	-		X904
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870