DRSC/TRiP Functional Genomics Resources

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Protein Alignment MCOLN1 and mcoln1b

DIOPT Version :10

Sequence 1:NP_065394.1 Gene:MCOLN1 / 57192 HGNCID:13356 Length:580 Species:Homo sapiens
Sequence 2:XP_073799733.1 Gene:mcoln1b / 795916 ZFINID:ZDB-GENE-130514-1 Length:574 Species:Danio rerio


Alignment Length:553 Identity:329/553 - (59%)
Similarity:410/553 - (74%) Gaps:25/553 - (4%)


- Green bases have known domain annotations that are detailed below.


Human     4 PAGPRGSETERLLTPNPGYGT---QAGP------SPAPPTPPEEEDLRRRLKYFFMSPCDKFRAK 59
            |:....:|.||||||..|||:   ..||      ........|||.|||:|||||||||||:.||
Zfish     8 PSAQAATEKERLLTPVMGYGSGDLNGGPLDLCSLGSQQQQQDEEEALRRKLKYFFMSPCDKYHAK 72

Human    60 GRKPCKLMLQVVKILVVTVQLILFGLSNQLAVTFREENTIAFRHLFLLGYSDGADDTFAAYTREQ 124
            ||||.||:||::||::|||||::||||||:.|.|:||||.:|:||||..|.:.:.:....:|::|
Zfish    73 GRKPYKLVLQLLKIIIVTVQLVMFGLSNQMVVAFKEENTDSFKHLFLRDYVEDSQEPLCLHTQKQ 137

Human   125 LYQAIFHAVDQYLALPDVSLGRYAYVRGGGDPWTNGSGLALCQRYYHRGHVDPANDTFDIDPMVV 189
            :::.|.:|:||||.|...|:||||||.|.|   .|.|.|.|||||:.:|.:||.||||||||.|:
Zfish   138 VHEHIRYAIDQYLILSQTSVGRYAYVPGVG---PNSSALYLCQRYFKKGTIDPVNDTFDIDPHVI 199

Human   190 TDCIQVDPPERPPPPPSDDLTLLESSSSYKNLTLKFHKLVNVTIHFRLKTINLQSLINNEIPDCY 254
            |||..|:|.:  |..|..||        |.|:||.|.|||||||.|:||.||:|::|||||||||
Zfish   200 TDCFGVNPSD--PSSPVQDL--------YPNITLNFQKLVNVTIEFQLKAINIQTIINNEIPDCY 254

Human   255 TFSVLITFDNKAHSGRIPISLETQAHIQECKHPSVFQHGDNSFRLLFDVVVILTCSLSFLLCARS 319
            |||:.|.||||||||::.:||..:|.|:||:.|:|..|||:..|:.|||:|.:.|.||.:||.||
Zfish   255 TFSITILFDNKAHSGKVKLSLLNEAFIKECRDPNVSGHGDSYARVAFDVLVAVVCGLSLVLCGRS 319

Human   320 LLRGFLLQNEFVGFMWRQRGRVISLWERLEFVNGWYILLVTSDVLTISGTIMKIGIEAKNLASYD 384
            :|:|.:||:|.|.:.....||.:||.:||||:||||:||:.||||||..:.:||.||.|||:|||
Zfish   320 ILKGIMLQHELVCYFRVSLGRSVSLGDRLEFINGWYLLLIISDVLTIIASFIKIAIETKNLSSYD 384

Human   385 VCSILLGTSTLLVWVGVIRYLTFFHNYNILIATLRVALPSVMRFCCCVAVIYLGYCFCGWIVLGP 449
            |||||:||||||||||||||.:||..|||||.|||.|.|:|:|||||.|.||:||||||||||||
Zfish   385 VCSILMGTSTLLVWVGVIRYFSFFQKYNILIVTLRAAFPNVIRFCCCAAAIYMGYCFCGWIVLGP 449

Human   450 YHVKFRSLSMVSECLFSLINGDDMFVTFAAMQAQQGRSSLVWLFSQLYLYSFISLFIYMVLSLFI 514
            ||.||||||.|||||||||||||||.||:.:: |.|  :|||:|||:|||:||||||||||||||
Zfish   450 YHAKFRSLSTVSECLFSLINGDDMFATFSEVE-QSG--TLVWVFSQIYLYTFISLFIYMVLSLFI 511

Human   515 ALITGAYDTIKHPGGAGAEESELQAYIAQCQDS 547
            ||||||||||........:.|||..:||:|.|:
Zfish   512 ALITGAYDTITQQTQDVPQVSELHRFIAECTDT 544

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MCOLN1NP_065394.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..38 13/42 (31%)
Dileucine motif, mediates targeting to lysosomes. /evidence=ECO:0000269|PubMed:16497227 11..16 3/4 (75%)
Interaction with phosphoinositides. /evidence=ECO:0000269|PubMed:22733759 42..62 16/19 (84%)
Extracellular/lumenal pore loop. /evidence=ECO:0000305|PubMed:28112729 107..121 1/13 (8%)
ELD_TRPML1 112..292 CDD:410966 94/179 (53%)
PKD_channel <388..524 CDD:462341 107/135 (79%)
Selectivity filter. /evidence=ECO:0000305|PubMed:29019983 469..474 4/4 (100%)
Required for palmitoylation and association with membranes. /evidence=ECO:0000269|PubMed:16497227 565..567
Dileucine internalization motif, mediates AP2 complex-dependent internalization. /evidence=ECO:0000269|PubMed:16497227 573..578
mcoln1bXP_073799733.1 None
Blue background indicates that the domain is not in the aligned region.

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