DRSC/TRiP Functional Genomics Resources

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Protein Alignment MCOLN1 and mcoln1

DIOPT Version :10

Sequence 1:NP_065394.1 Gene:MCOLN1 / 57192 HGNCID:13356 Length:580 Species:Homo sapiens
Sequence 2:NP_001011347.1 Gene:mcoln1 / 496811 XenbaseID:XB-GENE-982338 Length:565 Species:Xenopus tropicalis


Alignment Length:574 Identity:368/574 - (64%)
Similarity:453/574 - (78%) Gaps:29/574 - (5%)


- Green bases have known domain annotations that are detailed below.


Human    10 SETERLLTPNPGYGTQAGPSPAPPTPPEEEDLRRRLKYFFMSPCDKFRAKGRKPCKLMLQVVKIL 74
            ||..|||:|:|.|||:....|:    |||..|||||||||||||||||||||||.||.||::||:
 Frog    18 SERRRLLSPSPNYGTRLCEFPS----PEEVQLRRRLKYFFMSPCDKFRAKGRKPYKLGLQLLKIM 78

Human    75 VVTVQLILFGLSNQLAVTFREENTIAFRHLFLLGYSDGADDTFAAYTREQLYQAIFHAVDQYLAL 139
            .|||||||||||||:.|.|:||||.||:||||..|:|.|:.|:|.||:|.:|:.:::||:||.:|
 Frog    79 FVTVQLILFGLSNQMVVQFKEENTEAFKHLFLKDYTDDAEKTYAVYTQEDVYEHLYYAVEQYFSL 143

Human   140 PDVSLGRYAYVRGGGDPWTNGSGLALCQRYYHRGHVDPANDTFDIDPMVVTDCIQVDPPERPPPP 204
            .:.:..||||.|    |: |.|.|::||:||.:||:|||||||:|||.|:|:|:.:||       
 Frog   144 SNQTTARYAYTR----PF-NQSALSVCQQYYRKGHIDPANDTFNIDPQVITNCLFLDP------- 196

Human   205 PSDDLTLLESSSSYKNLTLKFHKLVNVTIHFRLKTINLQSLINNEIPDCYTFSVLITFDNKAHSG 269
                   .|.|.||||.|:|||||:|:|:.|:||.||:|::|||||||||||::.|.||||||||
 Frog   197 -------AEPSQSYKNFTIKFHKLINLTVQFQLKAINIQTIINNEIPDCYTFTITILFDNKAHSG 254

Human   270 RIPISLETQAHIQECKHPSVFQHGDNSFRLLFDVVVILTCSLSFLLCARSLLRGFLLQNEFVGFM 334
            ::.|.|:.:|.|:|||.|||:..|||..||.|||:|||:|.|||:|||||::||.|||:||..|:
 Frog   255 KVKIQLDNEAKIKECKDPSVYGRGDNHSRLAFDVLVILSCILSFILCARSIVRGLLLQHEFAQFV 319

Human   335 WRQRGRVISLWERLEFVNGWYILLVTSDVLTISGTIMKIGIEAKNLASYDVCSILLGTSTLLVWV 399
            ..:.|..|||.:|||||||||:||:.|||||:|||:||||||:|..|||||||||||||||||||
 Frog   320 HYRHGLTISLSDRLEFVNGWYLLLIISDVLTVSGTVMKIGIESKTFASYDVCSILLGTSTLLVWV 384

Human   400 GVIRYLTFFHNYNILIATLRVALPSVMRFCCCVAVIYLGYCFCGWIVLGPYHVKFRSLSMVSECL 464
            ||||||:||..|||||.|||||||:|:|||||||||||||||||||||||||||||:||||||||
 Frog   385 GVIRYLSFFQKYNILIVTLRVALPNVIRFCCCVAVIYLGYCFCGWIVLGPYHVKFRTLSMVSECL 449

Human   465 FSLINGDDMFVTFAAMQAQQGRSSLVWLFSQLYLYSFISLFIYMVLSLFIALITGAYDTIKHPGG 529
            |||||||||||||:.|   |..|.|||.|||||||:|||||||||||||||||||||:|||....
 Frog   450 FSLINGDDMFVTFSEM---QNSSYLVWAFSQLYLYTFISLFIYMVLSLFIALITGAYETIKCQNS 511

Human   530 ---AGAEESELQAYIAQCQDSPTSGKFRRGSGSACSLLCCCGRDPSEEHSLLVN 580
               :|:.::.|..|||:|:|||:|||||..:.::||:.|||.:....:..:.||
 Frog   512 SDFSGSNDNALYQYIAECKDSPSSGKFRSANSTSCSMFCCCTQPTHCDEDVAVN 565

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MCOLN1NP_065394.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..38 12/27 (44%)
Dileucine motif, mediates targeting to lysosomes. /evidence=ECO:0000269|PubMed:16497227 11..16 2/4 (50%)
Interaction with phosphoinositides. /evidence=ECO:0000269|PubMed:22733759 42..62 19/19 (100%)
Extracellular/lumenal pore loop. /evidence=ECO:0000305|PubMed:28112729 107..121 5/13 (38%)
ELD_TRPML1 112..292 CDD:410966 92/179 (51%)
PKD_channel <388..524 CDD:462341 117/135 (87%)
Selectivity filter. /evidence=ECO:0000305|PubMed:29019983 469..474 4/4 (100%)
Required for palmitoylation and association with membranes. /evidence=ECO:0000269|PubMed:16497227 565..567 1/1 (100%)
Dileucine internalization motif, mediates AP2 complex-dependent internalization. /evidence=ECO:0000269|PubMed:16497227 573..578 0/4 (0%)
mcoln1NP_001011347.1 ELD_TRPML1 116..277 CDD:410966 92/179 (51%)
PKD_channel 297..506 CDD:462341 169/211 (80%)

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