DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNFX1 and CG6204

DIOPT Version :9

Sequence 1:	NP_066363.1	Gene:	ZNFX1 / 57169	HGNCID:	29271	Length:	1918	Species:	Homo sapiens
Sequence 2:	NP_651229.2	Gene:	CG6204 / 42877	FlyBaseID:	FBgn0039165	Length:	903	Species:	Drosophila melanogaster

Alignment Length:	1151	Identity:	288/1151 - (25%)
Similarity:	467/1151 - (40%)	Gaps:	337/1151 - (29%)

- Green bases have known domain annotations that are detailed below.

Human   169 GLKELLSHSSMKSNFLELICQVLRKAC-SSKMDRQSVLHV-LGILKNSKFLKVCLPAYVVGMITE 231
            ||::.|....::.|...:.|....:.| .|::....:.|. ..:.:.:..||  :||  :.|...
  Fly    19 GLEKSLKSLELQKNEEYIECPPSERKCPPSEVGEYVMQHTRFSLTELTNALK--MPA--IDMFLY 79

Human   232 PIPDIRNQYPEHI---SNI--ISLLQDLV------------SVFPASSVQETSMLVSLLPTSLNA 279
            .:.|.|:.:...:   .|:  :.|..|::            .||.::..::|::|..:    .|.
  Fly    80 FLSDKRDLFENQVLATDNVKRVGLFVDVLWSLCELELGGFDEVFLSAFSRQTALLDKI----KNL 140

Human   280 LRASGVDIEEETEKNLEKVQTIIEH----LQEKRREGTLRVDTYTLVQ------PE-AEDHVESY 333
            |:|.....:.:.|..|     |:.|    |....:.|.|....|.||:      |. ..|.::..
  Fly   141 LQAKAAVAKCDAESAL-----ILSHSKWMLLRAHKHGLLSHQGYELVELYKKLAPSFKSDMIDGL 200

Human   334 RTMP----------IYPTYNEVHLDERPFLRPN------IISGKYDSTAIYLDTHFRLLREDFVR 382
            ....          ||||. |..|.:.....||      ::|   |....|::....||||||:.
  Fly   201 EAFTGNFSHNVKGLIYPTL-ETLLGKDATKAPNEEEDEGLVS---DKVVKYVNALRNLLREDFLA 261

Human   383 PLREGILEL-----LQSFEDQGLRKRKFDDIRIYFDTRIITPMCSSSGIVYKVQFDTKPLK--FV 440
            ||.|.:.:|     :...:.|||   .:.|:.:..:.:..... ..|.:..|||| ||..|  :.
  Fly   262 PLVEFVQQLRSGTDVDELKQQGL---LWSDVHLTLNPQFANAQ-RHSLVFLKVQF-TKESKNAYK 321

Human   441 RWQNSKRLLYGSLVCMSKD-NFETFLFATVSNREQEDLCRGIVQLCFNEQSQQLLAEVQPSDSF- 503
            .|.||  :..|:|:|::.. .|:..:.|:|...|.|.|....:       |.|::.:....:::
  Fly   322 TWLNS--IKSGTLLCLTTSLAFDDLILASVGYTEPEKLKEDCL-------SVQIVKQYNIGNAYN 377

Human   504 ---LMVETTAYFEAYRHVLEGLQEVQEEDVPFQRNIVECNSHVKEPRYLLMGGRYDFTPLIENPS 565
               :|.:...:||.|..|...|.....|..|..|.||:....:..|.|:..|.:..|
  Fly   378 RPLIMFQAPVFFEPYLRVHNYLSTCSTEKFPMGRYIVDGQMEIPPPAYMKPGVKLSF-------- 434

Human   566 ATGEFLRNVEGLRHPRINVLDPGQWPSKEALKLDDSQMEALQFALTRELAIIQGPPGTGKTYVGL 630
                   |::.....::          .|.|.|::||..|.:.||.||.:|||||||||||::.:
  Fly   435 -------NMKPFTLDKL----------PEDLHLNESQKTAFKEALCREFSIIQGPPGTGKTHLSV 482

Human   631 KIVQALLTNESVWQISLQKFPILVVCYTNHALDQFLEGIYNCQKTSIVRVGGRSNSEILKQFTLR 695
            ::|.:|:.|..    :|...||:|:.|||::||:||..|....: .|:|.|.:|....:.:|.|
  Fly   483 QLVNSLIQNAK----ALGTGPIIVLTYTNNSLDKFLVKISRYTQ-EILRFGNQSRDPQISKFNL- 541

Human   696 ELRNKREFRRNLPMHLRRAYMSIMTQMKESEQELHEGAKTLECTMRGVLREQYLQKYISPQHWES 760
            ....|.|.   :|..|:|.:..:..:.||..:.|.
  Fly   542 STTIKPEL---VPPRLKRIWWLVNCEYKEKFRNLQ------------------------------ 573

Human   761 LMNGPVQDSEWICFQHWKHSMMLEWLGLGVGSFTQSVSPAGPENTAQAEGDEEEEGEEESSLIEI 825
                                      ||                  .|..|..||..::
  Fly   574 --------------------------GL------------------YANFDGSEESYQD------ 588

Human   826 AEEADLIQADRVIEEEEVVRPQRRKKEESGADQELAKMLLAMRLDHCGTGTAAGQEQATGEWQTQ 890
                                                              |.|.||
  Fly   589 --------------------------------------------------TLAAQE--------- 594

Human   891 RNQKKKMKKRVKDELRKLNTMTAAEANEIEDVWQLDLSSRWQLYRLWLQLYQADTRRKILSYERQ 955
                            |||.:
  Fly   595 ----------------KLNQV-------------------------------------------- 599

Human   956 YRTSAERMAELRLQEDLHILKDAQVVGMTTTGAAKYRQILQKVEPRIVIVEEAAEVLEAHTIATL 1020
                |||:..||:.....:.::..::.||||.||::..:.:.::.:.|:.|||||:.|||.:|.|
  Fly   600 ----AERIETLRMVFQFFLAREKDLLAMTTTCAARHNFLFRLLQSKCVLFEEAAEIQEAHIVACL 660

Human  1021 SKACQHLILIGDHQQLRPSANVYDLAKNFNLEVSLFERLVKVNIPFVRLNYQHRMCPEIARLLTP 1085
            :...:|:||:|||:||:|.:....:.     ::||||||:...:||.|||.|:||...|:.||.|
  Fly   661 TPHTEHVILVGDHKQLQPFSGSRKVP-----QISLFERLIVAGLPFSRLNLQYRMRSCISELLVP 720

Human  1086 HIYQDLENHPSVLKYEKIKGVSSNLFFVEHNFPEQEIQEGKSHQNQHEAHFVVELCKYFLCQ--E 1148
            .||.:|....||.:||.|:.:|.||:||:||.||..:.: .|..|.:||..:.:|.: ||.|  :
  Fly   721 SIYDELLCSESVKEYEDIRLMSKNLYFVQHNQPEHCMSD-MSIGNLYEAGVLAKLTE-FLIQKAQ 783

Human  1149 YLPSQITILTTYTGQLFCLRKLMPAKTFAGVRVHVVDKYQGEENDIILLSLVRSNQEGKVGFLQI 1213
            |..|.|.||:.|.||:.|::..:|....:.|:|..||.:||.|.:|:||||||||..|::|||:.
  Fly   784 YKHSDIVILSPYNGQIECIKNALPQNYRSTVQVASVDSFQGLEANIVLLSLVRSNISGRIGFLRQ 848

Human  1214 SNRICVALSRAKKGMYCIGNMQMLAKV--PLWSKIIHTLRENNQIG 1257
            :||:|||||||:..:|.:||:.:|...  .:|:.|:..|:|||.||
  Fly   849 ANRVCVALSRARWALYIVGNVTILKDTFPKIWNPIVKRLKENNAIG 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNFX1	NP_066363.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..140
		AAA_11	597..1038	CDD:289831	91/440 (21%)
		AAA_19	604..>667	CDD:289986	29/62 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	796..819		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	876..896		4/19 (21%)
		DNA2	<903..1254	CDD:224037	124/354 (35%)
		AAA_12	1051..1234	CDD:289832	84/184 (46%)
		NF-X1-zinc-finger	1372..1417	CDD:100116
		NF-X1-zinc-finger	1461..1505	CDD:100116
		LELP1	<1498..1562	CDD:291701
CG6204	NP_651229.2	AAA_11	449..679	CDD:289831	91/441 (21%)
		AAA_19	467..>513	CDD:289986	23/49 (47%)
		UvrD_C_2	688..869	CDD:304668	84/182 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141559
Domainoid	1	1.000	151	1.000	Domainoid score	I4359
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H10877
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D271662at2759
OrthoFinder	1	1.000	-	-		FOG0005665
OrthoInspector	1	1.000	-	-		oto89278
orthoMCL	1	0.900	-	-		OOG6_101077
Panther	1	1.100	-	-	LDO	PTHR10887
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3084
SonicParanoid	1	1.000	-	-		X4066
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.780