DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNFX1 and hrr1

DIOPT Version :9

Sequence 1:	NP_066363.1	Gene:	ZNFX1 / 57169	HGNCID:	29271	Length:	1918	Species:	Homo sapiens
Sequence 2:	NP_588411.2	Gene:	hrr1 / 2539248	PomBaseID:	SPCC1739.03	Length:	999	Species:	Schizosaccharomyces pombe

Alignment Length:	1081	Identity:	325/1081 - (30%)
Similarity:	508/1081 - (46%)	Gaps:	203/1081 - (18%)

- Green bases have known domain annotations that are detailed below.

Human   232 PIPDIRNQYPEH--ISNIISLLQDLVSVFPASSVQETSMLVSLLPTSLNALRASGVDIE-EETEK 293
            |.|:..::...|  .|||.:...:..|........|||               ...|.| .:.:|
pombe    32 PEPETLSEMKRHPLYSNIFNADNNTTSFTEQIETSETS---------------KTQDSEGNKVDK 81

Human   294 NLEKVQTIIEHLQEKRREGTLRVDTYTLV-------------QPEAEDH----VESYRTMPIYPT 341
            ||::.::|       ||:.::..| |.|.             :.|.|.|    ..|:|.:|..||
pombe    82 NLKENKSI-------RRKRSIDND-YELSNVKRNDITSGKNREFENEHHPASDTSSWRELPSIPT 138

Human   342 YNEVHLDERPFLRPNIISGKYDSTAIYLDTHFRLLREDFVRPLREGILELLQSFEDQGLRKRKFD 406
            ..|: ..:...|..|.|.|.|.|...||..|:||||||.|.||||.:|            :.|.:
pombe   139 LEEL-TSKSVELPSNNIYGGYKSFEDYLSIHYRLLREDAVSPLRESVL------------RYKVN 190

Human   407 -------DIRIYFDTRIITPMCSSSGIVYKVQFDTKPLKFVRWQNSKRLLYGSLVCMSKDNFETF 464
                   .:.:|...||.....|||.|..|:.|..:..|.::|..|:||:.||||.:|.|:|:||
pombe   191 PNYITGSSLAVYDHVRIDGYTISSSVIAAKLSFSVRAKKKIKWATSRRLISGSLVLLSNDDFQTF 255

Human   465 LFATVSNREQEDLCRGIVQLCFNEQSQQLLAEVQPSDSFLMVE-TTAYFEAYRHVLEGLQEVQEE 528
            ...||..|....|.:...::  :.:.:.:...:.|.:.::|:| |:.|:|||:|||..||.:...
pombe   256 RIGTVCARPLSGLNKHPHEI--DVKFEDISISLDPREEYVMIEATSGYWEAYKHVLRSLQRLSAS 318

Human   529 DVPFQRNIVECNSHVKEPRYLLMGGRYDFTPLIENPSATGEFLRNVEGLRHPRINVLD---PGQW 590
            ..|.:..:|.|.|:.:..:::....|.....:::|.|             ...:|.|:   ||::
pombe   319 TFPMKDYLVHCKSNQETAKHIQNNPRIRINSILKNNS-------------QKIVNALEPFGPGEY 370

Human   591 PSKEALKLDDSQMEALQFALTRELAIIQGPPGTGKTYVGLKIVQALLTNESVWQISLQKFPILVV 655
                  .||.||::|.|..||:.|:||||||||||::|.||.::.||.|     ......||||.
pombe   371 ------ILDSSQLKAYQSMLTKRLSIIQGPPGTGKSFVTLKAIETLLEN-----THSHVLPILVA 424

Human   656 CYTNHALDQFLEGIYNCQKTSIVRVGGRSNSEILKQFTLRELRNKREFRRNLPMHLRRAYMSIMT 720
            |.||||:||.|..:.: |..|::|:|.|:....:...|:        |::  ..|.:.::.:...
pombe   425 CQTNHAVDQILIRLLH-QGASVMRLGSRTKDPEIAAVTI--------FQK--AKHTKHSFKAAYN 478

Human   721 QMKESEQELHEGAKTLECTMRGVLRE----QYLQK--YISPQHWESLMNGPVQDSEWICFQHWKH 779
            :::..:|.|   .|.:...|.....|    .||..  .|:....|||.|    ::|||
pombe   479 EIRHKKQRL---IKQITNIMHNFNLEFVTLSYLHSKGIITTSQLESLRN----NTEWI------- 529

Human   780 SMMLEWLGLGVGSFTQSVSPAGPENTAQAEGDEEEE------GEEESSLIEIAEEADLIQADRVI 838
                           .||:..| |.|       |||      |:.:..||..:|..|..:.:..|
pombe   530 ---------------SSVAENG-EKT-------EEELISIWLGDAKVELITPSEITDGFEEELQI 571

Human   839 EEEEVVRPQRRKKEESGADQELAKMLLAMRLDHCGTGTAAGQEQATGEWQTQRNQKKKMKKRVKD 903
            :.|::...| ::.|:|||..|                     |:..|         |.:..|.|.
pombe   572 DPEKLEEIQ-KEAEDSGALME---------------------EELRG---------KFINLRCKY 605

Human   904 ELRKLNTMTAAEAN---EIEDVWQLDLSSRWQLYRLWLQLYQADTRRKILSYERQY-RTSAERMA 964
            ...||.|:...|.:   .|.::|.:...||..:|..||:...|...:::....|.| :...||:.
pombe   606 LFSKLTTLHEKEIDTLLTIPNIWDIPEYSRGIIYCRWLESAYAAAEKELNRLYRFYLKVDRERIG 670

Human   965 ELRLQEDLHILKDAQVVGMTTTGAAKYRQILQKVEPRIVIVEEAAEVLEAHTIATLSKACQHLIL 1029
            ....:..: :|:.|.|:||||||..|||.||:::.|:|..:||||:|||...|..:..:.:.|:|
pombe   671 FSNKRAAI-LLRGANVIGMTTTGLNKYRDILERINPKICFIEEAADVLEGPIIPAVFPSLEQLVL 734

Human  1030 IGDHQQLRPSANVYDLAKN-FNLEVSLFERLVKVNIPFVRLNYQHRMCPEIARLLTPHIYQDLEN 1093
            ||||:||||..:.|.|.:: |||.:|:|||||:.::.:.||..|.||.|:|.||:: .:|:||.:
pombe   735 IGDHKQLRPGCSTYALRQDPFNLSISMFERLVENDMEYTRLTMQRRMHPQIRRLVS-SVYEDLSD 798

Human  1094 HPSVLKYEKIKGVSS-NLFFVEHNFPEQEIQEG-KSHQNQHEAHFVVELCKYFLCQEYLPSQITI 1156
            :.....:..|.|:.. ..||:.|:  ..|..:| .|..|..||..:|:...|.:.....|.:||.
pombe   799 YEITKYWPSIPGMGEIRRFFLTHS--RIEDNDGFASKINLFEAQMLVQFAVYLINNGVEPQKITC 861

Human  1157 LTTYTGQLFCLRKLMP-----AKTFAGVRVHVVDKYQGEENDIILLSLVRSNQEGKVGFLQISNR 1216
            ||.|..|...:.:|:.     .|.|  ::|..||.|||||||::||||||:|...:||||...:|
pombe   862 LTFYAAQKDLIERLLSESLNREKHF--IKVATVDGYQGEENDVVLLSLVRNNDRTEVGFLSSPHR 924

Human  1217 ICVALSRAKKGMYCIGNMQMLAKV-PLWSKIIHTLRENNQI 1256
            :||:||||::|::..||.|::|:. |||...|:||..:..|
pombe   925 VCVSLSRARRGLFIFGNAQLVAESNPLWWDAINTLMNDETI 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNFX1	NP_066363.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..140
		AAA_11	597..1038	CDD:289831	134/456 (29%)
		AAA_19	604..>667	CDD:289986	32/62 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	796..819		9/28 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	876..896		2/19 (11%)
		DNA2	<903..1254	CDD:224037	135/363 (37%)
		AAA_12	1051..1234	CDD:289832	72/189 (38%)
		NF-X1-zinc-finger	1372..1417	CDD:100116
		NF-X1-zinc-finger	1461..1505	CDD:100116
		LELP1	<1498..1562	CDD:291701
hrr1	NP_588411.2	DNA2	158..965	CDD:224037	290/929 (31%)
		AAA_19	387..446	CDD:289986	31/64 (48%)
		AAA_12	757..942	CDD:289832	72/189 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	117	1.000	Domainoid score	I1742
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005665
OrthoInspector	1	1.000	-	-		oto147659
orthoMCL	1	0.900	-	-		OOG6_101077
Panther	1	1.100	-	-	O	PTHR10887
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3084
SonicParanoid	1	1.000	-	-		X4066
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.840