DRSC/TRiP Functional Genomics Resources

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Protein Alignment JPH2 and Jph2

DIOPT Version :10

Sequence 1:NP_065166.2 Gene:JPH2 / 57158 HGNCID:14202 Length:696 Species:Homo sapiens
Sequence 2:NP_067541.1 Gene:Jph2 / 59091 MGIID:1891496 Length:696 Species:Mus musculus


Alignment Length:706 Identity:608/706 - (86%)
Similarity:644/706 - (91%) Gaps:20/706 - (2%)


- Green bases have known domain annotations that are detailed below.


Human     1 MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAGVYTWPSGNTFEGYWS 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse     1 MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAGVYTWPSGNTFEGYWS 65

Human    66 QGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSSSSGAKYEGTWNNGLQDGYGTETYADGGTYQ 130
            ||||||||||||||||||||||||||||||||||::|||||||||||||||||||||||||||||
Mouse    66 QGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSTNSGAKYEGTWNNGLQDGYGTETYADGGTYQ 130

Human   131 GQFTNGMRHGYGVRQSVPYGMAVVVRSPLRTSLSSLRSEHSNGTVAPDSPASPASDGPALPSPAI 195
            ||||||||||||||||||||||||||||||||||||||||||||||||   |||:|||.||||.:
Mouse   131 GQFTNGMRHGYGVRQSVPYGMAVVVRSPLRTSLSSLRSEHSNGTVAPD---SPAADGPMLPSPPV 192

Human   196 PRGGFALSLLANAEAAARAPKGGGLFQRGALLGKLRRAESRTSVGSQRSRVSFLKSDLSSGASDA 260
            |||||||:|||.||||    :..|||.||.|||:|||:|||||:||||||:|||||:||||||||
Mouse   193 PRGGFALTLLATAEAA----RPQGLFTRGTLLGRLRRSESRTSLGSQRSRLSFLKSELSSGASDA 253

Human   261 ASTASLGEAAEGADE-AAPFEADIDATTTETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRH 324
            |||.||.|.|||.|: ||||:||||||||||||||||||||||||||||||||||||||||||||
Mouse   254 ASTGSLAEGAEGPDDAAAPFDADIDATTTETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRH 318

Human   325 GYGCTTLPDGHREEGKYRHNVLVKDTKRRMLQLKSNKVRQKVEHSVEGAQRAAAIARQKAEIAAS 389
            |||.||||||||||||||||||||.||||:|.|||:||||||||.||||||||||||||||||||
Mouse   319 GYGRTTLPDGHREEGKYRHNVLVKGTKRRVLPLKSSKVRQKVEHGVEGAQRAAAIARQKAEIAAS 383

Human   390 RTSHAKAKAEAAEQAALAANQESNIARTLARELAPDFYQPGPEYQKRRLLQEILENSESLLEPPD 454
            ||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||:
Mouse   384 RTSHAKAKAEAAEQAALAANQESNIARTLAKELAPDFYQPGPEYQKRRLLQEILENSESLLEPPE 448

Human   455 RGAGAAGLPQPPRESPQLHERETPRPEGGSPSPAGTPPQPKRPRPGVSKDGLLSPGAWNGEPSGE 519
            ||.| .|||:.|||||||||||||:||||.||||||||||||||||.|||||||||:|||||.||
Mouse   449 RGLG-TGLPERPRESPQLHERETPQPEGGPPSPAGTPPQPKRPRPGASKDGLLSPGSWNGEPGGE 512

Human   520 GSRSVTPSEGAGRRSPARPATERMAIEALQAPPAPSREPEVALYQGYHSYAVRTTPPEPPPFED- 583
            |||..|||:|||||||||||:|.|||||||.|||||:|||||:|:|||||||||.||||||.|| 
Mouse   513 GSRPATPSDGAGRRSPARPASEHMAIEALQPPPAPSQEPEVAMYRGYHSYAVRTGPPEPPPLEDE 577

Human   584 -----QPEPEVSGSESAPSSPATAPL---QAPTLRGPEPARETPAKLEPKPIIPKAEPRAKARKT 640
                 :|||||..|:|||.||.:|.:   :.|..|.|.||::  |.||||||:|||||:||||||
Mouse   578 QEPEPEPEPEVRRSDSAPPSPVSATVPEEEPPAPRSPVPAKQ--ATLEPKPIVPKAEPKAKARKT 640

Human   641 EARGLTKAGAKKKARKEAALAAEAEVEVEEVPNTILICMVILLNIGLAILFVHLLT 696
            |||||:|||||||.|||.|.|.||||||||||||:|||||||||||||||||||||
Mouse   641 EARGLSKAGAKKKGRKEVAQAKEAEVEVEEVPNTVLICMVILLNIGLAILFVHLLT 696

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
JPH2NP_065166.2 COG4642 <2..143 CDD:443680 138/140 (99%)
MORN 1. /evidence=ECO:0000255 14..36 21/21 (100%)
MORN 2. /evidence=ECO:0000255 38..59 20/20 (100%)
MORN 3. /evidence=ECO:0000255 60..79 18/18 (100%)
MORN 4. /evidence=ECO:0000255 82..104 19/21 (90%)
PLN03185 101..>334 CDD:215619 201/233 (86%)
MORN 5. /evidence=ECO:0000255 106..128 21/21 (100%)
MORN 6. /evidence=ECO:0000255 129..151 21/21 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 164..193 23/28 (82%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 250..282 24/32 (75%)
MORN 7. /evidence=ECO:0000255 291..313 21/21 (100%)
MORN 8. /evidence=ECO:0000255 314..336 20/21 (95%)
Bipartite nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9ET78 351..365 10/13 (77%)
PHA03247 <444..642 CDD:223021 153/206 (74%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 448..652 158/212 (75%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9ET78 495..499 3/3 (100%)
Jph2NP_067541.1 COG4642 <2..143 CDD:443680 138/140 (99%)
MORN 1. /evidence=ECO:0000255 14..36 21/21 (100%)
MORN 2. /evidence=ECO:0000255 38..59 20/20 (100%)
MORN 3. /evidence=ECO:0000255 60..79 18/18 (100%)
MORN 4. /evidence=ECO:0000255 82..104 19/21 (90%)
PLN03185 103..>328 CDD:215619 200/231 (87%)
MORN 5. /evidence=ECO:0000255 106..128 21/21 (100%)
MORN 6. /evidence=ECO:0000255 129..151 21/21 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 164..192 25/30 (83%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 246..273 20/26 (77%)
COG4642 <284..>338 CDD:443680 52/53 (98%)
MORN 7. /evidence=ECO:0000255 285..307 21/21 (100%)
MORN 8. /evidence=ECO:0000255 308..330 20/21 (95%)
Bipartite nuclear localization signal. /evidence=ECO:0000269|PubMed:30409805 345..359 10/13 (77%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 439..664 169/227 (74%)
PHA03307 442..>643 CDD:223039 150/203 (74%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:30409805 488..492 3/3 (100%)

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