DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment JPH2 and jph2

DIOPT Version :10

Sequence 1:NP_065166.2 Gene:JPH2 / 57158 HGNCID:14202 Length:696 Species:Homo sapiens
Sequence 2:NP_001082833.1 Gene:jph2 / 553333 ZFINID:ZDB-GENE-030131-9848 Length:781 Species:Danio rerio


Alignment Length:817 Identity:445/817 - (54%)
Similarity:527/817 - (64%) Gaps:157/817 - (19%)


- Green bases have known domain annotations that are detailed below.


Human     1 MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAGVYTWPSGNTFEGYWS 65
            ||||||:||||||||||||||||||||:|||||||||:|||||:||||.||||||||||:|||||
Zfish     1 MSGGRFEFDDGGAYCGGWEGGKAHGHGICTGPKGQGEFSGSWNYGFEVVGVYTWPSGNTYEGYWS 65

Human    66 QGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSSSSGAKYEGTWNNGLQDGYGTETYADGGTYQ 130
            ||||||||:||||.|:||||||||||||||.|.|..|||||||||||||||||||||||||||:|
Zfish    66 QGKRHGLGVETKGHWIYKGEWTHGFKGRYGTRISQGSGAKYEGTWNNGLQDGYGTETYADGGTFQ 130

Human   131 GQFTNGMRHGYGVRQSVPYGMAVVVRSPLRTSLSSLRSEHSNGT-VAPDSP------ASPASDGP 188
            ||||.|||||||||||||||||.||.||||.||||||||||||| :..|.|      ||......
Zfish   131 GQFTGGMRHGYGVRQSVPYGMAAVVHSPLRNSLSSLRSEHSNGTLLQQDVPVITTTNASGQETPV 195

Human   189 ALPSPAIP-RGGFALSLLANAEAAARAPKGGGLFQRGALLGKLRRAESRTSVGSQRSRVSFLKSD 252
            .||.|..| ||||||:|..:.:|.  .||..|||:||:.||||::::||||:.||:|::|||:::
Zfish   196 NLPMPLGPSRGGFALTLQVDPDAV--KPKKSGLFRRGSFLGKLKKSDSRTSLSSQKSKISFLRTE 258

Human   253 --LSSGASDAASTASLGEAAEGADEA---APFEADIDATTTETYMGEWKNDKRSGFGVSERSSGL 312
              |||.||||.||.|||| :||..|.   .|.||||||||||.||||||||||||:|:|||||||
Zfish   259 SALSSAASDANSTISLGE-SEGEGEGHNFPPVEADIDATTTEVYMGEWKNDKRSGYGISERSSGL 322

Human   313 RYEGEWLDNLRHGYGCTTLPDGHREEGKYRHNVLVKDTKRRMLQLKSNKVRQKVEHSVEGAQRAA 377
            :||||||:|.||||||||.|:|.:|||||.:|:|||..|::|:|||..|::||||.|:|||||||
Zfish   323 KYEGEWLNNQRHGYGCTTFPEGGKEEGKYVNNMLVKSVKKKMIQLKGTKIKQKVERSLEGAQRAA 387

Human   378 AIARQKAEIAASRTSHAKAKAEAAEQAALAANQESNIARTLARELAPDFYQPGPEYQKRRLLQEI 442
            |||:||||||.|||:|||:|.:||||||:|||.||:|||.:||||:|.|:||||||.|:|.|||:
Zfish   388 AIAKQKAEIANSRTAHAKSKGDAAEQAAVAANNESSIARVVARELSPSFHQPGPEYIKKRALQEV 452

Human   443 LENSESLLEPPDRG-----AGAAGLPQPPRESPQLHERETPRPEGGSPSPAGTPPQ-----PKRP 497
            .|::|::    :.|     .....||.|| |||.:||.|..||   |.:||.||..     |:.|
Zfish   453 AESNENM----ETGIHEPLLAEDSLPTPP-ESPFMHEMEGLRP---SSTPARTPSPTLVIVPQAP 509

Human   498 RPGVSKDG--LLSPGAWNGEPSGEGSRSVTPSEGAGRRSPARPAT-------------------- 540
                |||.  |||||:|||:....||.|.:.|. ||.|..:||.|                    
Zfish   510 ----SKDDPHLLSPGSWNGDKISRGSASKSSSR-AGSRPNSRPITPAAAPTPDAAPEEHSAPSSK 569

Human   541 ----------------ERMAIEALQ--------APPAPSREPEVALYQGYHSYAVRTT------- 574
                            ..|.|:|||        |.|||..:|            |||.       
Zfish   570 VPSRTPSRQSAKVEQGSDMEIKALQKTDIESKVAEPAPVAKP------------VRTNLILPNDE 622

Human   575 --PPEP----PPFEDQPEPE------------------VSGSESAPS------------------ 597
              ||.|    .|....|||:                  .|.:||.|.                  
Zfish   623 EEPPRPAPKLSPKAATPEPKAAEVKHRADTRQPINERPASMTESKPEYRTDVREEKKFINKVEPK 687

Human   598 -SPATAPLQAPTLRGPEPARETPAKLEPKPII-PKAEPRAKAR-KTEARGLTKAGAKKKARKEAA 659
             ||...|..||.:. |:|..:|..|.||||:: |.|:|.||.. |||.|       ::...|..:
Zfish   688 PSPKREPSPAPKVT-PKPEPKTVPKPEPKPVVMPVAKPVAKVEAKTETR-------QRSIMKAPS 744

Human   660 LAAEAEVEVEEVPNTILICMVILLNIGLAILFVHLLT 696
            ...:..:|:||.||||:|||||.|||||||||||:|:
Zfish   745 EMTQPSMELEEGPNTIMICMVIFLNIGLAILFVHILS 781

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
JPH2NP_065166.2 COG4642 <2..143 CDD:443680 125/140 (89%)
MORN 1. /evidence=ECO:0000255 14..36 20/21 (95%)
MORN 2. /evidence=ECO:0000255 38..59 17/20 (85%)
MORN 3. /evidence=ECO:0000255 60..79 16/18 (89%)
MORN 4. /evidence=ECO:0000255 82..104 17/21 (81%)
PLN03185 101..>334 CDD:215619 168/245 (69%)
MORN 5. /evidence=ECO:0000255 106..128 21/21 (100%)
MORN 6. /evidence=ECO:0000255 129..151 19/21 (90%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 164..193 17/35 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 250..282 18/36 (50%)
MORN 7. /evidence=ECO:0000255 291..313 19/21 (90%)
MORN 8. /evidence=ECO:0000255 314..336 17/21 (81%)
Bipartite nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9ET78 351..365 6/13 (46%)
PHA03247 <444..642 CDD:223021 87/305 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 448..652 87/311 (28%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9ET78 495..499 1/3 (33%)
jph2NP_001082833.1 COG4642 <2..143 CDD:443680 125/140 (89%)
COG4642 <300..>355 CDD:443680 42/54 (78%)
PRK10263 <465..>734 CDD:236669 84/290 (29%)
PRK11633 <619..>727 CDD:236940 27/108 (25%)

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