DRSC/TRiP Functional Genomics Resources

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Protein Alignment JPH2 and jp

DIOPT Version :10

Sequence 1:NP_065166.2 Gene:JPH2 / 57158 HGNCID:14202 Length:696 Species:Homo sapiens
Sequence 2:NP_523525.2 Gene:jp / 34274 FlyBaseID:FBgn0032129 Length:1054 Species:Drosophila melanogaster


Alignment Length:1050 Identity:304/1050 - (28%)
Similarity:424/1050 - (40%) Gaps:396/1050 - (37%)


- Green bases have known domain annotations that are detailed below.


Human     1 MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAGVYTWPSGNTFEGYWS 65
            ::||||||:|||.|||||:.|||||||:|||||.||.|:|:||:||||:|.|.||||:.:||.|.
  Fly    47 INGGRFDFEDGGTYCGGWDEGKAHGHGVCTGPKHQGAYAGAWNYGFEVSGSYIWPSGSHYEGQWQ 111

Human    66 QGKRHGLGIETKGRWLYKGEWT-HGFKGRYGIRQSSSSGAKYEGTWNNGLQDGYGTETYADGGTY 129
            .|:|||||:|..||.:|:|||: .|.|||||:|:|:.|.||||||||.|.|||.|.|||||||.|
  Fly   112 NGRRHGLGVEQIGRQIYRGEWSKDGHKGRYGVRESTVSTAKYEGTWNEGYQDGSGCETYADGGKY 176

Human   130 QGQFTNGMRHGYGVRQSVPYGMAV-VVRSPLRTSLSSLRSEHSNGTVAPDSPASPASDGPALPSP 193
            |||:..|.|||||:|.|.|:|:|. ..|..|..||||||| ..||..|  .....|.:       
  Fly   177 QGQWQEGKRHGYGIRTSAPFGLASHHRRKNLHASLSSLRS-GENGNAA--KMVEKAEE------- 231

Human   194 AIPRGGFALSLLANAEAAARAPKGGGLFQRGALLGKLRRAESRTSVGSQRSRVS--FLKSDLSSG 256
              .||||.|:..::.....|........::|.|:....|.:..|....:|..::  .::|.:||.
  Fly   232 --IRGGFVLTAKSDKLPVRRNSLTDKTGKKGFLMNLKMRKQRSTGDLEKRGTIASGSIRSTMSSA 294

Human   257 A--SDAASTASLGEAAEGADEAAPF---EADIDATTTETYMGEWKNDKRSGFGVSERSSGLRYEG 316
            :  |..:..::|...:...:..|.|   :..:|.|..||||||||.|||.|.||:|||.||:|||
  Fly   295 SWISTGSEQSNLTTKSNHTESNASFTMEDEQLDPTVVETYMGEWKKDKRCGHGVAERSDGLKYEG 359

Human   317 EWLDNLRHGYGCTTLPDGHREEGKYRHNVLVKDTKRRMLQL-KSNKVRQKVEHSVEGAQRAAAIA 380
            ||.:|.:||||.||..||..|||||::|:|:...|::.|.| :|.|:|.::..::..||||..:|
  Fly   360 EWYNNRKHGYGVTTFRDGTVEEGKYKNNILITSQKKKHLFLARSRKLRDRIAAALSSAQRALKMA 424

Human   381 RQKAEIAASRTSHAKAKAEAAEQAALAANQESNIARTLARELAPDF------------------Y 427
            .|::::|.||.:.|.|||:.|:.||..|..:...|..:|||.||||                  :
  Fly   425 MQRSDMAISRMATAAAKAQNADAAAEQARMDCENAVRMAREFAPDFKPSVLERFEKLRFRERERF 489

Human   428 QPGP-----------------------------------------------------EYQKRRLL 439
            :|||                                                     :.|:||:.
  Fly   490 RPGPAAASDASVKMGVGLQTQQQQQQQGQFSPTSSSGSDAYATQAQRQQQYLNMQQQQQQQRRMS 554

Human   440 QEILEN---------SESL---------------------------------------------- 449
            |:..|:         |:.|                                              
  Fly   555 QQKHESECPVPPSMYSQQLPVSPQTDLSGMVSQAQPSHAQVISAINQMYHQQQHQQQQQLNQQQS 619

Human   450 ------------LEPPDR--------------------------GAGA----------------- 459
                        .:||.:                          |:|.                 
  Fly   620 NPQMNPAYQFQQQQPPGQAKINPNLNANLKQNQAPNQNQTQMPFGSGTNQVTVSPQQQQLLQQQQ 684

Human   460 -----------------------AGLPQPP--------------RESPQLHERE----------- 476
                                   .||.|.|              |.:.|:.:::           
  Fly   685 QQQQQQLLQQQQLQQQQQLQQQHQGLQQQPSLHASPTHNASNLLRRASQMQQQQIQETAAAAAMA 749

Human   477 ----------------------------------------------------------------- 476
                                                                             
  Fly   750 ANAAAMAAAQQQQRSGRPPMLGQMGQQSSIDHFDHYKRPPSRDSSIDRYARAASRLSGAFAGSRQ 814

Human   477 ---------TPRPEGGSPSPAGTPPQPKRPRPG-VSKDGLLSPGA------WNGE-PSGEG---- 520
                     .|...||:.:|.|      |||.| |.:.....|||      .||. |||.|    
  Fly   815 ASLDRSGIADPVTNGGTSTPDG------RPRAGSVFRGSTPQPGAGTSTMTGNGSLPSGNGGGRL 873

Human   521 SRSVTPSEGAGRRSPARPATERMAIEALQAPPAPSREPEVALYQGYHSYAVRTTPPEPPPFEDQP 585
            ||:.|||.|||.|:|::..||.:    ..:|..|..  :|.|.|       ||...:..|...||
  Fly   874 SRAGTPSLGAGGRAPSQGKTEPL----FSSPNQPFE--DVLLRQ-------RTLGQDIIPSPSQP 925

Human   586 EPEVSGSES--APSSPATAPLQAPTLR-----GPEPARETP--AKLEPKPIIPKAE--PRAKARK 639
            :    .:||  .|:.|||....|...:     |.:..:..|  ..|:.|..:|..:  |||    
  Fly   926 K----RTESLYLPAKPATPVGMAMGGKGGGGGGGKKMKSVPINVTLQRKKSMPDFQELPRA---- 982

Human   640 TEARGLTKAGAKKKARKEAALAAEAEVEVEE--VPNTI----------------LICMVILLNIG 686
            |||....:..|...||:|   |...::||.|  ..|.:                |:.:|::.|:.
  Fly   983 TEAMSREEVSALGSARRE---AVRRQIEVNERLKANPLLYLVSPQVKDWFVRQQLMLLVLIFNVA 1044

Human   687 LAILFVHLLT 696
            ||:|||::||
  Fly  1045 LALLFVYMLT 1054

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
JPH2NP_065166.2 COG4642 <2..143 CDD:443680 96/141 (68%)
MORN 1. /evidence=ECO:0000255 14..36 17/21 (81%)
MORN 2. /evidence=ECO:0000255 38..59 14/20 (70%)
MORN 3. /evidence=ECO:0000255 60..79 10/18 (56%)
MORN 4. /evidence=ECO:0000255 82..104 13/22 (59%)
PLN03185 101..>334 CDD:215619 100/240 (42%)
MORN 5. /evidence=ECO:0000255 106..128 17/21 (81%)
MORN 6. /evidence=ECO:0000255 129..151 13/21 (62%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 164..193 9/28 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 250..282 7/36 (19%)
MORN 7. /evidence=ECO:0000255 291..313 16/21 (76%)
MORN 8. /evidence=ECO:0000255 314..336 14/21 (67%)
Bipartite nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9ET78 351..365 6/14 (43%)
PHA03247 <444..642 CDD:223021 70/452 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 448..652 71/449 (16%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9ET78 495..499 2/3 (67%)
jpNP_523525.2 COG4642 <49..194 CDD:443680 98/144 (68%)
PLN03185 84..>384 CDD:215619 143/311 (46%)

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