Protein Alignment JPH2 and jph-1

DIOPT Version :10

• Sequence 1: NP_065166.2
• Gene: JPH2 / 57158
• HGNCID: 14202
• Length: 696
• Species: Homo sapiens
• Sequence 2: NP_492193.2
• Gene: jph-1 / 266843
• WormBaseID: WBGene00002179
• Length: 747
• Species: Caenorhabditis elegans
• Alignment Length: 815
• Identity: 289/815 - (35%)
• Similarity: 392/815 - (48%)
• Gaps: 196/815 - (24%)

Human     1 MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAGVYTWPSGNTFEGYWS 65
            |:||||||||||.|.||||.|||||||:||||:.:|||:|:|::||||:||||||||||::|.|.
 Worm     1 MNGGRFDFDDGGTYVGGWEEGKAHGHGVCTGPQAKGEYAGAWHYGFEVSGVYTWPSGNTYQGQWQ 65

Human    66 QGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSSSSGAKYEGTWNNGLQDGYGTETYADGGTYQ 130
            .|||||||||.:||||||||||.|:|||||:|||::|.|:|:|||:.|..||||||.|.|.|:||
 Worm    66 NGKRHGLGIEQRGRWLYKGEWTQGYKGRYGVRQSANSQARYQGTWSAGFHDGYGTEIYVDSGSYQ 130

Human   131 GQFTNGMRHGYGVRQSVPYGMAVVVRSPLRT--SLSSLRSEHSNGTVAPDSPASPASDGPALPSP 193
            ||:..|||||||:|:|..|..|...||..:|  ||:||||    |.|..::.|........|..
 Worm   131 GQWLRGMRHGYGIRKSTTYEKAAKFRSKSQTHASLTSLRS----GRVEEENAAEEHRHKEGLSG- 190

Human   194 AIPRGGFALSLLANAEAAARAPKG---GGLFQRGALLGKLRRAESRTSVGSQRSRVSFLKSDLSS 255
               ||||.|.  ||:.|..|..:.   ..|..:..||..| |.:.:.|.|....||:.:...|.|
 Worm   191 ---RGGFVLR--ANSSAPQRRRRSLSERSLAVKRTLLSGL-RIKKQHSTGDIHQRVASMTGSLRS 249

Human   256 GASDAASTASLGEAAEGADEAAPFEADIDATTTETYMGEWKNDKRSGFGVSERSSGLRYEGEWLD 320
            ..|..:.|:.......|..:  |.|..::.::.||||||||||.||||||.|||.||:|:|||.:
 Worm   250 SGSTMSCTSEDSLHHHGLQQ--PEEEAVEESSIETYMGEWKNDMRSGFGVCERSDGLKYQGEWAN 312

Human   321 NLRHGYGCTTLPDGHREEGKYRHNVLVKDTKRR-MLQLKSNKVRQKVEHSVEGAQRAAAIARQKA 384
            |.:.|||.||..||.:|||:|::|:|:..::|: ::.::::|.|:|:|.::..|.|||:||:|||
 Worm   313 NAKCGYGVTTFKDGTKEEGRYKNNILIASSRRKGVIFMRASKFREKLEQALGAASRAASIAQQKA 377

Human   385 EIAASRTSHAKAKAEAAEQAALAANQESNIARTLARELAPDFYQPGPEYQKRRLL---------- 439
            :|||||||.|:.::|.|...|..||.:|.:||..|::..|.|.|||    .||||
 Worm   378 DIAASRTSTARERSEQASFIARQANDDSEVARIHAKQFDPSFKQPG----TRRLLKDNNGGESFG 438

Human   440 -------------------QEILENSESL-----LEPPDRGAGAAGLP----------------- 463
                               |...|.:.|:     :.||.:......:|
 Worm   439 TDLSDAISYSRHLSQTHSKQHSFEQTLSVDMAEDMTPPSKAYHNHVMPNSNTNHVNFMPQYGYSD 503

Human   464 -----QPPRESPQLHERETPRPEGGSPS---------PAGTPPQPKRPRPGVSKDGLLSPGAWN- 513
                 |.|..|..|.:...|..:...||         |....||....:||.|.....:|...:
 Worm   504 PNSQLQTPINSQDLLQPHIPNIDPSIPSVSIVQDDEKPLILQPQTNISQPGPSNLSTQAPNVMSS 568

Human   514 ----------------GEPSGEGSRSVTPS-------------EGAGRRSPARPATERMAIEALQ 549
                            |....:..|...||             .|..|||....|.:|..
 Worm   569 RFSLSDDHYDQYVMAGGAQQQQKLRRNRPSLMRQADVNESCAASGLNRRSTLASARDRNG----- 628

Human   550 APPAPSREPEVALYQGYHSYAVRTTPPEPPPFEDQPEPEVSGSESAPSSPATAPLQAPTLRGPEP 614
                                             |...|...|:..|      |.|.|.|..| :.
 Worm   629 ---------------------------------DVNHPGAIGATHA------AKLTAATSDG-DN 653

Human   615 ARETP--AKLEPKPIIPKAEPRAKARKTEARGLTKAGAKK----KARKEAAL------------A 661
            ....|  |:||.:.:        :.|:.||..|  ||.::    :..:||||            |
 Worm   654 MGSLPNLAELETQGV--------RLRREEAARL--AGQRRQEVLRENEEAALLRANPLRHFLQPA 708

Human   662 AEAEVEVEEVPNTILICMVILLNIGLAILFVHLLT 696
            ..|.:....:|     .::.:.||.|.:||.||||
 Worm   709 FRAWLVRWRIP-----ILLAIANISLLMLFYHLLT 738

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
JPH2	NP_065166.2	COG4642	<2..143	CDD:443680	101/140 (72%)
		MORN 1. /evidence=ECO:0000255	14..36		16/21 (76%)
		MORN 2. /evidence=ECO:0000255	38..59		15/20 (75%)
		MORN 3. /evidence=ECO:0000255	60..79		11/18 (61%)
		MORN 4. /evidence=ECO:0000255	82..104		16/21 (76%)
		PLN03185	101..>334	CDD:215619	100/237 (42%)
		MORN 5. /evidence=ECO:0000255	106..128		13/21 (62%)
		MORN 6. /evidence=ECO:0000255	129..151		14/21 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	164..193		8/28 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	250..282		7/31 (23%)
		MORN 7. /evidence=ECO:0000255	291..313		18/21 (86%)
		MORN 8. /evidence=ECO:0000255	314..336		12/21 (57%)
		Bipartite nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9ET78	351..365		3/14 (21%)
		PHA03247	<444..642	CDD:223021	43/265 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	448..652		47/271 (17%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9ET78	495..499		0/3 (0%)
jph-1	NP_492193.2	COG4642	<2..145	CDD:443680	102/142 (72%)
		MORN	283..303	CDD:308220	17/19 (89%)
		MORN	306..328	CDD:308220	12/21 (57%)