DRSC/TRiP Functional Genomics Resources

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Protein Alignment JPH2 and jph2

DIOPT Version :10

Sequence 1:NP_065166.2 Gene:JPH2 / 57158 HGNCID:14202 Length:696 Species:Homo sapiens
Sequence 2:XP_002933232.1 Gene:jph2 / 100493044 XenbaseID:XB-GENE-964567 Length:770 Species:Xenopus tropicalis


Alignment Length:793 Identity:455/793 - (57%)
Similarity:539/793 - (67%) Gaps:120/793 - (15%)


- Green bases have known domain annotations that are detailed below.


Human     1 MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAGVYTWPSGNTFEGYWS 65
            |||||||||||||||||||||||||||:|||||||||||||||:||||.|:||||||||||||||
 Frog     1 MSGGRFDFDDGGAYCGGWEGGKAHGHGICTGPKGQGEYSGSWNYGFEVVGIYTWPSGNTFEGYWS 65

Human    66 QGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSSSSGAKYEGTWNNGLQDGYGTETYADGGTYQ 130
            |||||||||||||||:||||||||||||||:|||.||||||||||||||||||||||||||||||
 Frog    66 QGKRHGLGIETKGRWVYKGEWTHGFKGRYGVRQSMSSGAKYEGTWNNGLQDGYGTETYADGGTYQ 130

Human   131 GQFTNGMRHGYGVRQSVPYGMAVVVRSPLRTSLSSLRSEHSNGTVAPDSPASPASDGPALPSPAI 195
            ||||||||||.|||||||||||.||||||||||:||||||||||:......|.:.|.  :.:|.|
 Frog   131 GQFTNGMRHGCGVRQSVPYGMAAVVRSPLRTSLTSLRSEHSNGTLVQHDNISVSPDN--IVAPTI 193

Human   196 PRGGFALSLLANAEAAARAPKGGGLFQRGALLGKLRRAESRTSVGSQRSRVSFLKSD--LSSGAS 258
            .||||||||.|:.||.....|  |||:||:||||||::||:||:.||||::|||||:  :||.||
 Frog   194 NRGGFALSLYADTEALKSQKK--GLFRRGSLLGKLRKSESKTSLSSQRSKLSFLKSESGVSSAAS 256

Human   259 DAASTASLGEAAEGADEAAPFEADIDATTTETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLR 323
            ||.||.|.|:..| :::..|.|:||||||||.||||||||||||||||||||||:||||||||||
 Frog   257 DANSTVSFGDGTE-SEDFPPVESDIDATTTEVYMGEWKNDKRSGFGVSERSSGLKYEGEWLDNLR 320

Human   324 HGYGCTTLPDGHREEGKYRHNVLVKDTKRRMLQLKSNKVRQKVEHSVEGAQRAAAIARQKAEIAA 388
            |||||||.|||.:||||||:||.:|..|:|::.|||.|:||||:.|:|||.||.|||||||||||
 Frog   321 HGYGCTTFPDGKKEEGKYRNNVFIKGMKKRVIPLKSAKIRQKVDSSIEGALRAGAIARQKAEIAA 385

Human   389 SRTSHAKAKAEAAEQAALAANQESNIARTLARELAPDFYQPGPEYQKRRLLQEILENSESL--LE 451
            |||:|||||||.|||||.|||.||.||||:||||:||||||||||.||:|||||:||:|.:  .|
 Frog   386 SRTTHAKAKAEGAEQAAQAANSESGIARTMARELSPDFYQPGPEYIKRKLLQEIIENAEQMDHKE 450

Human   452 PPDRGAGAAGLPQ-PPRESPQLHERETPRPEGG-----SPSPAGTPPQPKRPRPGVSKDGLLSPG 510
            |.   ..|...|| .|.|||.||.:::.:.|..     ||:.|.:||..|:|:....|:..|||.
 Frog   451 PT---TPAHQEPQATPSESPLLHVKQSSKREVSPARTPSPTSAESPPDAKKPKQSSKKEKGLSPS 512

Human   511 AWNGEPSGEGSRSVTPSEGAGRRSPARPATERMAIEALQAPPAPSREPEVALYQGYHSYAVRTTP 575
            .|||:.:...|||:|||...|:.:..:         .:...|    :|::..::|||||||||:|
 Frog   513 NWNGDQNRASSRSITPSNIPGKGNQTK---------LMNKVP----DPDIEFHKGYHSYAVRTSP 564

Human   576 PEPP-PFEDQ--PEPEVSGSESAPS--------SPATA-----------------------PLQA 606
            ..|| .:|:.  |.|:.:.....|.        ||:::                       |...
 Frog   565 VTPPLDYEEHAFPSPKATPEAKTPDIKDQVKEVSPSSSKDQDAKAKAVSRRSEIGRESQLKPNDE 629

Human   607 PTLRG---------------------------PEPARETPAKLEPKPI---IPKAEPRAKARKTE 641
            |...|                           |||  :|..|.|||.:   ..||.|:|...|.|
 Frog   630 PKSEGREEKMQSKTFSKSDSKSDIYETKSVQKPEP--KTVQKPEPKAMQKAEQKAAPKAAVAKPE 692

Human   642 ARGLTKAGAKK-------KARKEAALAAE----------------AEVEVEEVPNTILICMVILL 683
            .:...||..:|       |:..:|:|.||                .|.|:||.|:||:|||||||
 Frog   693 TKAAPKAAPQKPEPKSVAKSESKASLKAETKSLVKKGVQVAAVTNTEEEIEERPDTIMICMVILL 757

Human   684 NIGLAILFVHLLT 696
            ||||:||||||||
 Frog   758 NIGLSILFVHLLT 770

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
JPH2NP_065166.2 COG4642 <2..143 CDD:443680 132/140 (94%)
MORN 1. /evidence=ECO:0000255 14..36 20/21 (95%)
MORN 2. /evidence=ECO:0000255 38..59 17/20 (85%)
MORN 3. /evidence=ECO:0000255 60..79 18/18 (100%)
MORN 4. /evidence=ECO:0000255 82..104 19/21 (90%)
PLN03185 101..>334 CDD:215619 172/234 (74%)
MORN 5. /evidence=ECO:0000255 106..128 21/21 (100%)
MORN 6. /evidence=ECO:0000255 129..151 20/21 (95%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 164..193 12/28 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 250..282 15/33 (45%)
MORN 7. /evidence=ECO:0000255 291..313 21/21 (100%)
MORN 8. /evidence=ECO:0000255 314..336 20/21 (95%)
Bipartite nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9ET78 351..365 7/13 (54%)
PHA03247 <444..642 CDD:223021 72/269 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 448..652 72/275 (26%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9ET78 495..499 2/3 (67%)
jph2XP_002933232.1 COG4642 <2..143 CDD:443680 132/140 (94%)
PLN03185 99..>348 CDD:215619 184/253 (73%)
PTZ00449 <447..705 CDD:185628 73/275 (27%)

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