Protein Alignment TMEM63C and CSC1

DIOPT Version :10

• Sequence 1: NP_065164.2
• Gene: TMEM63C / 57156
• HGNCID: 23787
• Length: 806
• Species: Homo sapiens
• Sequence 2: NP_013342.1
• Gene: CSC1 / 850942
• SGDID: S000004231
• Length: 782
• Species: Saccharomyces cerevisiae
• Alignment Length: 845
• Identity: 164/845 - (19%)
• Similarity: 299/845 - (35%)
• Gaps: 224/845 - (26%)

Human    38 VPTVLCLNIALWVLVLVVYSFLRKAAW----------DYGRLALLIHNDSLTSLIYGEQSEKTSP 92
            |.|.|.:..:|.:..|:.:|.|.| .|          |.|.|.|...|.   |.::|
Yeast    33 VTTQLTIATSLGIFALLSFSILLK-KWPRLYASRRYKDDGNLRLPSWNQ---SSLFG-------- 85

Human    93 SETSLEMERRDKGFCSWFFNSITMKDEDLINKCGDDARIYIVFQYHLIIFVLIICIPSLGIILPI 157
                            |......::||.::...|.||.:::.|....|..:.|.|..|:.:|.|:
Yeast    86 ----------------WLTVLYKIRDEQILEYAGLDAYVFLSFFKMCIKLLSIFCFFSVCVISPV 134

Human   158 NY--TGSVLDWSS---------HFARTTIV------NVSTESK---LLWLHSLLSFFY-FITNFM 201
            .|  ||.:.|.:.         |..:..:.      |.|...:   .||::.|.::|: ||...|
Yeast   135 RYHFTGKIDDGNDDDDSESSLIHLVKRIVEGSGDGDNHSAPERTNVYLWMYVLFTYFFTFIAIKM 199

Human   202 FMAH--HCL----GFAPRNSQKVTRTLMITYVPKDIEDPELIIKHFHEAYPGSVVTRVHFCYDVR 260
            .:|.  |.:    .:..:.:....||:.::.:|.::.|.|.:.....:...|: |:.:..|
Yeast   200 AVAETKHVVSTRQAYLGKQNTITDRTIRLSGIPIELRDSEALKTRIEQLKIGT-VSSITIC---- 259

Human   261 NLIDLDDQRRHAMRGRLFYTAKAKKTGKVMIRIHPCARLCFCKCWTCFKEVDAEQYYSELEEQLT 325
                    |......:||:..|     |::..:.       .|...|.:|:...|.|||....|.
Yeast   260 --------REWGPLNKLFHCRK-----KILKNLE-------LKYSECPRELRTRQPYSENYHLLG 304

Human   326 DE------------------------------------------FNAELNRVPLKRLDLIFVTFQ 348
            :|                                          |..|::.:......|.|:
Yeast   305 NEQSGAVTHGENVPSSNNNDEDTILYSQISLGERPKMKIGYRGIFGKEVDAIEYLEQQLKFI--- 366

Human   349 DSRMAKRVRKDYK------YVQCGVQPQQSSVTTIV--KSYYWRVTMAPHPKDIIWKHLSVRRFF 405
            |:.:.:..::.|.      .....|...|.:...::  :.:|:...:||.|.||.|.|:.:.|..
Yeast   367 DAEIIEARKQHYSATPTAFVTMDSVANAQMAAQAVLDPRVHYFITRLAPAPHDIKWDHVCLSRKD 431

Human   406 WWARFIAINTFLFFLFFFLTTPAIIMNTIDMYNVTRPIEKLQNPIVTQFFPSV--ML----WGFT 464
            ...:..:...|:.....||..|...:.|:           |....:::|:|||  :|    |...
Yeast   432 RLTKVYSTTVFIGLSSLFLVIPVSYLATL-----------LNLKTLSKFWPSVGQLLKDHQWAAN 485

Human   465 VILPL------------IVYFSAFLEAH-----WTRSSQNLVMVHKCYIFL-VFMVVILPSMGLT 511
            ::..|            |.||..:|.::     ::....:||..:..|||: :|:|..|......
Yeast   486 IVTGLLPTYLFTLLNFGIPYFYEYLTSYQGLVSYSEEEISLVSKNFFYIFVNLFLVFTLAGTASN 550

Human   512 SLDVFLRWLFDIYYLEQASIRFQ-CVFLPDNGAFFVNYVITAALLGTGM---ELLRLGSLFCYST 572
                  .|   .|..:...|.:| ...:.:...|:|:.:|   |.|.||   :||.:|||..:..
Yeast   551 ------YW---AYLSDTTKIAYQLATSVKEFSLFYVDLII---LQGIGMFPFKLLLVGSLIGFPL 603

Human   573 RLFFSRSEPERVNIRKNQAIDFQFGREYAWMMNVFSVVMAYSITCPIIVPFGLLYLCMKHLTDRY 637
             :......|.:.|...|..| |.||.:....:.:..:.:.||:....|:..||.|..:.....:|
Yeast   604 -VKIKAKTPRQRNELYNPPI-FNFGLQLPQPILILIITLIYSVMSTKILTSGLAYFIIGFYVYKY 666

Human   638 NMYYSFAPTKLNEQIHMAAVSQAIFAPLL-GLFWMLFFSILRLGSLHAI--------TIFSLSTL 693
            .:.  ||...|...  ...|...||..:: ||   |.|.:...|:|...        .:|.|..:
Yeast   667 QLI--FATDHLPHS--TGKVWPLIFRRIIVGL---LLFQLTMTGTLAGFEGGWVLSSCLFPLPVV 724

Human   694 LIAMVIAFVGIFLGKLRMVA-----DYEPEEEEIQTVFDMEPSSTSSTPTSLLYVATVLQEPELN 753
            .:..:..|...:|...:.:|     :||.:...:.:..:.|   :.:.|    |..:.|:.|.|:
Yeast   725 TLCFLYDFEKNYLPLSKYIALSSIREYERDNSTVNSANEEE---SYAYP----YAVSELEGPMLD 782

Human   754  753
            Yeast   783  782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TMEM63C	NP_065164.2	RSN1_TM	44..203	CDD:433613	40/189 (21%)
		PHM7_cyt	220..398	CDD:464272	37/227 (16%)
		RSN1_7TM	427..680	CDD:460661	62/281 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	755..781
CSC1	NP_013342.1	COG5594	1..782	CDD:227881	163/843 (19%)