Protein Alignment SLC44A2 and Ctl2

DIOPT Version :10

• Sequence 1: NP_001350540.1
• Gene: SLC44A2 / 57153
• HGNCID: 17292
• Length: 711
• Species: Homo sapiens
• Sequence 2: NP_651670.1
• Gene: Ctl2 / 43440
• FlyBaseID: FBgn0039637
• Length: 796
• Species: Drosophila melanogaster
• Alignment Length: 792
• Identity: 257/792 - (32%)
• Similarity: 388/792 - (48%)
• Gaps: 121/792 - (15%)

Human    11 KHGTPQKYDPTFKGPIY-NRGCTDIICCVFLLLAIVGYVAVGIIAWTHGDPRKVIYPTDSRGEFC 74
            |:|.|.:||..|.||.. :|.|||:.|.:..:|.:.|:..:...|..:||..|::.||||....|
  Fly    10 KYGEPLRYDRNFTGPRQRDRSCTDVPCLLLFVLFLGGWAFIAQYAIRNGDLNKLLVPTDSFNRKC 74

Human    75 G-QKGTKNENKPYLFYFNIVKCASPLVLLEFQCPTPQICVEKCPDRYLTYLNARSSRDFE--YYK 136
            | ..|..  ||..||:|::.:|..|||.:. .|.|||:|||.||.....:...:..:.|.  :.:
  Fly    75 GMDSGVL--NKKNLFFFDLNQCIDPLVPIT-GCDTPQVCVETCPRETFVWDTMKDKQSFAELHSR 136

Human   137 QFCV-----PGFKNNKGVAEVLQDGDCPAVLIPSKPLARRCFPAIHAYKGV-------------- 182
            ..|:     ...:....:.:.:....|....|.|.|..:||.  ....:||
  Fly   137 LICLSEEHKAQIRTKSDIQDAINQNQCARWYIKSAPFLKRCL--FEFSQGVCDYIPSFLLNGGRS 199

Human   183 -----LMVGNETT---------YE-----------DGHGSRKNITD---------LVEGAKKA-- 211
                 ::.||.||         |:           ..:|.:..:.:         |.|...|.
  Fly   200 RRELHMLPGNATTEVQMQADVMYQKMTDAQALVVPQANGKQTPVDEEPIIQCKRRLNEAVIKEKM 264

Human   212 -------------------NGVLEARQLAMRIFEDYTVSWYWIIIGLVIAMAMSLLFIILLRFLA 257
                               ||..:|:.|..:|.||...||..:::.....:..||::|.|:|:|:
  Fly   265 MQTDTRLAKLVGNMVAHFYNGTNDAQLLGEKIVEDLVNSWSIVLVACFCTLVASLIYIALMRWLS 329

Human   258 GIMVWVMIIMVILVLGYGIFHCYMEYSRLRGEAGSDVSLVDLGFQTDFRVYLHLRQTWLAFMIIL 322
            ..::|..|..|::.|..||:....:|  :..|....|.:..|...:..:..|..:.|||...|.:
  Fly   330 APILWFSIFGVLIGLLVGIYFSVKQY--IHWENTPTVPVHGLNLHSTVKNVLQNQNTWLYLSIFV 392

Human   323 SILEVIIILLLIFLRKRILIAIALIKEASRAVGYVMCSLLYPLVTFFLLCLCIAYWASTAVFLST 387
            .:..|:|:||:|.|||||.|||||.||.|:||..|:.::.:|:.::.|....||:.....::|.:
  Fly   393 GVCFVVILLLVIVLRKRIRIAIALTKEGSKAVSSVISTVFFPIFSWILFIAAIAFAIGVGLYLGS 457

Human   388 SNEAVYKIF-----------DDSPCPFTA------KTCNPETF--------PSSNESRQ-CPNAR 426
            ..:..:::.           :|..|...|      .:|.||.|        .|..::|. |.|..
  Fly   458 IGDPSFRMVRQLTKSGEVTTEDCVCEGPAINYTVGGSCKPEVFQQYCSVRLTSFFQNRNPCLNTT 522

Human   427 CQFAFYGGESGYHRALLGLQIFNAFMFFWLANFVLALGQVTLAGAFASYYWALRKPDDLPAFPLF 491
            |.|...........|:    .:|.|.|.||:.|:.|...:.||..||.:||..:| .|:|.|.|.
  Fly   523 CSFDSINNPIEIKWAI----FYNVFGFLWLSFFISAFSYMVLASTFARWYWTFKK-RDVPYFTLT 582

Human   492 SAFGRALRYHTGSLAFGALILAIVQIIRVILEYLDQRLKAAENKFAKCLMTCLKCCFWCLEKFIK 556
            .||.:...||.|::|||:||||||::||::|||:.::||..:|...:.::.|::|.||.||.|:|
  Fly   583 RAFFQTAVYHLGTVAFGSLILAIVRLIRLVLEYIHEKLKKYDNAVTRAILCCMRCFFWLLETFLK 647

Human   557 FLNRNAYIMIAIYGTNFCTSARNAFFLLMRNIIRVAVLDKVTDFLFLLGKLLIVGSVGILAFFFF 621
            |||||||||.||:|.|||:||.::|.|:|||.:||..||:||||||.|.|||:....|...::|.
  Fly   648 FLNRNAYIMCAIHGKNFCSSAADSFNLIMRNFLRVVTLDQVTDFLFFLSKLLLTAGAGASTYYFL 712

Human   622 THRIRIVQDTAPPLNYYWVPILTVIVGSYLIAHGFFSVYGMCVDTLFLCFCEDLERNDGSQERPY 686
            .:...|::     |||..||...|::.::||...||.||...||||||||.||.||||||.|:|:
  Fly   713 DNNPSIIR-----LNYIAVPTTVVVIAAFLITSVFFGVYSTAVDTLFLCFLEDCERNDGSPEKPF 772

Human   687 FMSPELRDILLK 698
            |||.:|..||.|
  Fly   773 FMSKQLMKILGK 784

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC44A2	NP_001350540.1	Choline_transpo	337..676	CDD:461337	143/364 (39%)
Ctl2	NP_651670.1	Choline_transpo	407..762	CDD:461337	143/364 (39%)