Protein Alignment SLC44A2 and Ctl1

DIOPT Version :10

• Sequence 1: NP_001350540.1
• Gene: SLC44A2 / 57153
• HGNCID: 17292
• Length: 711
• Species: Homo sapiens
• Sequence 2: NP_647884.1
• Gene: Ctl1 / 38523
• FlyBaseID: FBgn0035523
• Length: 691
• Species: Drosophila melanogaster
• Alignment Length: 714
• Identity: 202/714 - (28%)
• Similarity: 344/714 - (48%)
• Gaps: 134/714 - (18%)

Human    13 GTPQKYDPTFKGPIYNRGCTD----IICCVFLLLAIVGYVAVGIIAWTHGDPRKVIYPTDSRGEF 73
            |..|...|.:      |.|||    .|..:|.|..||    :.|.::.:|:|.::|...||.|..
  Fly    11 GEAQNNRPKY------RSCTDTCWLAIYIIFWLFLIV----IAIFSFVYGNPLRIINGYDSFGNT 65

Human    74 CGQK-----------GTKNENKPYLFYFNIVKCASPLVLLEFQCPTPQICVEKCPDRYLTYLNAR 127
            ||.|           |....:||.||||::.:....|          :|||:.||.:.:|    :
  Fly    66 CGVKYNEKFQGFPLSGMNTLDKPELFYFDVKELKKSL----------KICVKSCPAKTMT----K 116

Human   128 SSRDFEYYK----QFCVPGFKNNKGVAEVLQD-------GDCPAVLI-PSKPLARRCFPAIHAYK 180
            .|...|||.    |.|...: |.:.:.....|       |.||:..: .|.|:..||.|     |
  Fly   117 GSELLEYYSQTGTQLCKYDY-NMQQLTTAGNDAKTFNFLGPCPSFPVHESSPVLHRCVP-----K 175

Human   181 GVLMVGNETTYEDGHGSRKNITDLVEGAKKAN--GVLEARQLAMRIFEDYTVSWYWIIIGLVIAM 243
            |.                        |.|..|  .:|....:|.:...|...:|:.|.:...:|:
  Fly   176 GT------------------------GEKVQNYYDMLNNWDVAQQFVGDIYSTWHIIAMVCGLAL 216

Human   244 AMSLLFIILLRFLAGIMVWVMIIMVI---LVLGYGIFHCYMEYSRLRGEAG--SDVSLVDLGFQT 303
            .:|:..:.::.:|:.|:.|::.::||   :.|...:::.|.   .:|.::|  :..|:::
  Fly   217 LISIALVTMMHWLSRIVSWIICVLVIVASVALTVALWYAYY---NIRNKSGVNTQYSMLE----- 273

Human   304 DFRVYLHLRQTWLAFMIILSILEVIIILLLIFLRKRILIAIALIKEASRAVGYVMCSLLYPLVTF 368
               .::..:|..|...::.:|..:|:|:::.||:.::....||.:||.:.:..:...|:.||:.|
  Fly   274 ---EFVRNQQAVLTLAVLATITMIILIVVIYFLKNKLAGLSALFEEAGQCMMNLPGLLIAPLLAF 335

Human   369 FLLCLCIAYWASTAVFLSTSN---EAVYKIFDDS-----PCPFTAKTCNPETFPSSNESRQCPNA 425
            .:|...:::|.:..:.|:|::   ::....||:|     |.|..|...:..|  ..|:.|  |||
  Fly   336 LVLIAFLSFWVAVIICLATASSPGQSPIAPFDNSKAHQQPLPANALFVSNST--DVNDLR--PNA 396

Human   426 RCQFAFYGGESGYHRALLGLQIFNAFMFFWLANFVLALGQVTLAGAFASYYWALRKPDDLPAFPL 490
            |.::|    ::|..|::..:.:..   ..|...|:.|..|..||.|.|  :|..:||...|.
  Fly   397 RVEYA----DAGVLRSMFWIYVVG---LIWTVEFIFACQQFALAAAVA--FWYFQKPTSTPT--- 449

Human   491 FSAFGRALRYHTGSLAFGALILAIVQIIRVILEYLDQRLKAAENKFAKCLMTCLKCC---FWCLE 552
            |.|.|:.::||.|::|.|:.::.|.:|.|:||.||..:||..|:|.::|...|||||   ||.||
  Fly   450 FYAIGKLVKYHLGTVAKGSFVITIFKIPRLILTYLYAKLKKGEDKGSECAACCLKCCICGFWLLE 514

Human   553 KFIKFLNRNAYIMIAIYGTNFCTSARNAFFLLMRNIIRVAVLDKVTDFLFLLGKLLIVGSVGILA 617
            |||:|||.|||.::||...|||.:|..|:..:..|:::||.::.|.||:..|||:::....|::.
  Fly   515 KFIRFLNHNAYTVVAIESINFCPAAGIAWNAMATNVLQVATINSVGDFILFLGKVVVAALSGLIG 579

Human   618 FFFFTHRIRIVQDTAPPLNYYWVPILTVIVGSYLIAHGFFSVYGMCVDTLFLCFCEDLERNDGS 681
                   |.:::| .|.||:|..|::.:|:.|:.|||...|::.|.|||||||.|||...|..|
  Fly   580 -------IVLLKD-KPGLNFYMAPVIIIIIFSFFIAHIILSLFEMVVDTLFLCVCEDKTLNGRS 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC44A2	NP_001350540.1	Choline_transpo	337..676	CDD:461337	119/349 (34%)
Ctl1	NP_647884.1	Choline_transpo	287..629	CDD:461337	123/365 (34%)